Publications by authors named "BaiSong Chen"

Traditional free space optical communication (FSOC) and light detection and ranging (lidar) are typically separate entities. Integrated communication and sensing systems (ICSS) can harmoniously integrate environmental perception with data transmission, paving the way for efficient, safe, and intelligent vehicle. However, the performance of FSOC and lidar systems are often constrained by the traditional mechanical beam steering components, impacting beam scanning speed, system volume, and robustness.

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We present a sensitive and compact quantum cascade laser-based photoacoustic greenhouse gas sensor for the detection of CO CH and CO and discuss its applicability toward on-line real-time trace greenhouse gas analysis. Differential photoacoustic resonators with different dimensions were used and optimized to balance sensitivity with signal saturation. The effects of ambient parameters, gas flow rate, pressure and humidity on the photoacoustic signal and the spectral cross-interference were investigated.

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Article Synopsis
  • * This case report presents a 67-year-old male patient with advanced biliary tract cancer who achieved a remarkable 17-month progression-free survival (PFS) after receiving a combination of targeted therapy (anlotinib) and immunotherapy (toripalimab), despite initially experiencing disease progression.
  • * Following further treatment, including radiotherapy for lung metastasis, the patient enjoyed an additional 11 months of PFS, suggesting that
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Biliary tract cancers are solid tumors with poor prognosis and over 70% of patients present in advanced stages. The efficacy of second-line treatment for patients who progressed on GC chemotherapy is limited. Median OS of these patients is less than 1 year with palliative treatment.

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In this Letter, we report a bridge-connected three-electrode germanium-on-silicon (Ge-on-Si) avalanche photodiode (APD) array compatible with the complementary metal-oxide semiconductor (CMOS) process. In addition to the two electrodes on the Si substrate, a third electrode is designed for Ge. A single three-electrode APD was tested and analyzed.

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Bessel beam featured with self-healing is essential to the optical sensing applications in the obstacle scattering environment. Integrated on-chip generation of the Bessel beam outperforms the conventional structure by small size, robustness, and alignment-free scheme. However, the maximum propagation distance (Z) provided by the existing approaches cannot support long-range sensing, and thus, it restricts its potential applications.

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A sulfur dioxide (SO) gas sensor based on the photoacoustic spectroscopy technology in a sulfur hexafluoride (SF) gas matrix was demonstrated for SF decomposition components monitoring in the power system. A passive Q-switching laser diode (LD) pumped all-solid-state 266 nm deep-ultraviolet laser was exploited as the laser excitation source. The photoacoustic signal amplitude is linear related to the incident optical power, whereas, a random laser power jitter is inevitable since the immature laser manufacturing technology in UV spectral region.

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Two novel waveguide gratings for optical phased array transmitters are investigated. By offsetting the grating structures along the waveguide on the upper and lower surfaces of the silicon nitride (SiN) waveguide, the dual-level chain and dual-level fishbone structures can achieve 95% of unidirectional radiation with a single SiN layer by design. With apodized perturbation along the gratings, both structures can achieve uniform radiation without compromising the unidirectional radiation performance.

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To address the problem of traditional surface illuminated detectors being of low responsivity, this work proposes a large-size interdigitated "finger-type" germanium-on-silicon (Ge-on-Si) photodetector (PD) based on the surface illumination approach. For 1550 nm light with a surface incident power of -20 dBm at room temperature, the best responsivity of the PD achieved is ∼0.64 A/W at 0.

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Stem cell-based therapy may be the most promising method to cure skeletal muscle degenerative diseases such as Duchenne muscular dystrophy (DMD) and trauma in the future. Human amniotic fluid is enriched with early-stage stem cells from developing fetuses and these cells have cardiomyogenic potential both in vitro and in vivo. In the present study, we investigated the characteristics of human amniotic fluid-derived AF-type stem (HAF-AFS) cells by flow cytometry, immunofluorescence staining, reverse-transcription polymerase chain reaction, and osteogenic and adipogenic differentiation analysis.

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Purpose: This study assessed the use of vascular endothelial growth factor (VEGF) gene-modified endothelial progenitor cells (EPCs) seeded onto bladder acellular matrix grafts (BAMGs), to enhance the blood supply in tissue-engineered bladders in a porcine model.

Methods: Autologous porcine peripheral EPCs were isolated, cultured, expanded, characterized, and modified with the VEGF gene using an adenovirus vector. The expression of VEGF was examined using reverse transcriptase polymerase chain reaction (RT-PCR) and an enzyme-linked immunosorbent assay (ELISA).

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Evenly distributed sampling design is generally considered as an efficient sampling design. It is widely used in sampling for the environmental survey. In this paper, we present a novel method for generating N evenly distributed samples within a given irregular polygon via simulating the movements of some ideal homogeneous point charges.

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