Physical Activity among Rural Residents in Eastern, Central, and Western Provinces of China: A Cross-Sectional Survey.

Physical activity (PA) in which physical exercise (PE) is an important component is probably the most important intervention for preventing noncommunicable diseases (NCDs). However, few studies on PA and PE of rural residents in China were reported. This study conducted the first population-based cross-sectional survey in three provinces of China in 2021 that examined both PA and PE as well as the associated factors of rural residents.

Polysialic acid biosynthesis and production in Escherichia coli: current state and perspectives.

Polysialic acid (PSA) is a unique polysaccharide that plays critical roles in many bioprocesses, which makes it useful in a wide range of biomedical applications. The increased demand for PSA has led to considerable efforts to improve its production using bacteria, such as Escherichia coli. Bioprocess optimization and metabolic engineering have allowed the efficient production of PSA.

Enhanced production of polysialic acid by metabolic engineering of Escherichia coli.

A number of reports have described the production of polysialic acid (PSA), focusing on the fermentation and purification of PSA. However, little work has been done to strengthen the synthetic pathway of PSA to improve PSA production. In this study, an efficient process for enhanced production of PSA using a recombinant Escherichia coli strain was developed.

Enhanced production of N-acetyl-D-neuraminic acid by multi-approach whole-cell biocatalyst.

N-Acetyl-D-neuraminic acid (Neu5Ac) has attracted considerable interest due to its promising potential applications in medicine. Significant efforts have been made in whole-cell biocatalyst for Neu5Ac production, but the processes often result in suboptimal performance due to poor expression of enzymes, imbalances of pathway components, disturbance of competing pathways, and barriers of mass transport. In this study, we engineered Escherichia coli strains capable of producing Neu5Ac by assembling a two-step heterologous pathway consisting of N-acetyl-D-glucosamine 2-epimerase (AGE) and Neu5Ac aldolase (NanA).

[Advance in researches of drugs derived from marine bacteria].

Marine bacteria are capable of producing a lot of unique bioactive substances, and therefore provide a luxuriant resource for screening new drugs. Bioactive substances derived from marine bacteria have bright prospect in marine drugs development and research.