Publications by authors named "Bai-Jun Qin"
PANoptosis is a newly discovered type of cell death characterized by pyroptosis, apoptosis and/or necroptosis and has been implicated in the inflammatory response. Piezo1 is a mechanosensitive ion channel that plays important roles in physiological development and various diseases. However, whether cardiomyocytes undergo PANoptosis during myocardial ischaemia/reperfusion (I/R) injury and the role of Piezo1 in this process remain largely unexplored.
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- Safer and more effective treatments for acute pancreatitis (AP) are needed, and Qingjie Huagong decoction (QJHGD) has shown promising clinical effects but its mechanisms were unclear.
- The study aimed to explore how QJHGD influences AP both in cell cultures and in mouse models, using various biochemical and molecular techniques to analyze its effects.
- Results indicated that QJHGD enhances cell viability and reduces pancreatic injury by regulating a specific pathway involving circHipk3, miR-193a-5p, and NLRP3, which highlights a new mechanism for its therapeutic action against AP.
Necroptosis and apoptosis contribute to the pathogenesis of myocardial ischaemia/reperfusion (I/R) injury and subsequent heart failure. N-arachidonoylphenolamine (AM404) is a paracetamol lipid metabolite that has pleiotropic activity to modulate the endocannabinoid system. However, the protective role of AM404 in modulating I/R-mediated myocardial damage and the underlying mechanism remain largely unknown.
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- The study aimed to identify the key targets and mechanisms of Dahuang-Danshen (DH-DS) in treating acute pancreatitis (AP) using network pharmacology and animal experiments.
- Sixty-seven common targets were found, with MAPK3, JAK2, STAT3, and FOS highlighted as core targets, while gene ontology and pathway analyses identified cellular response and Th17 cell differentiation as main mechanisms.
- Animal tests confirmed that DH-DS effectively reduced inflammation and protected pancreatic tissue by inhibiting specific inflammatory markers and regulating Th17 cell differentiation.