Publications by authors named "Bai-Can Yang"
Article Synopsis
- Garsubelone A is a novel dimeric metabolite from Garcinia subelliptica, characterized by its complex heptacyclic structure with 10 stereogenic centers.
- The compound is believed to be formed biogenetically from monomers garsubelone B and secohyperforin through a Diels-Alder cycloaddition, resulting in a unique nonane core.
- Both compounds' structures and configurations were elucidated using advanced spectroscopic methods and X-ray diffraction, and their cytotoxic properties were tested.
Glycyrrhizae Radix et Rhizoma (Gancao in Chinese) is the most frequently used traditional Chinese medicine (TCM) owing to its various pharmacological effects and, more importantly, the synergistic effects that enhance the efficacy and reduce the toxicity of other TCMs. Areas covered: We reviewed publications, predominantly between 1990 and 2018, that examined pharmacokinetic interactions between Gancao and other TCMs, or the bioactive constituents of these TCMs. This review focuses on the underlying mechanisms and the components responsible for the pharmacokinetic modulation by Gancao.
View Article and Find Full Text PDFPharmacokinetic studies are crucial for elucidating the effective constituents and formula compatibility of traditional Chinese medicines (TCMs). However, studies have usually been limited to single dosages and detection of systemic blood concentrations. To obtain comprehensive pharmacokinetic information, here we propose a multi-dosage and multi-sampling (blood from portal vein or systemic circulation, and liver) strategy to comparatively study the pharmacokinetics of multi-form TCMs, i.
View Article and Find Full Text PDFObjective: To evaluate the pharmacokinetics and tissue distribution of liposomal brucine (LB) for dermal application.
Methods: Pharmacokinetics and tissue distribution were studied by in vivo animal testing. High performance liquid chromatography (HPLC) was used to detect the concentration of brucine in rats' skin, plasma and various tissues.
Aim: To prepare a novel transdermal preparation of liposomal brucine (LB) and investigate its pharmaceutical/pharmacodynamic characterization.
Methods: LB was prepared by a modified ethanol-dripping method. Its drug encapsulation efficiency (EE), particle size, in vitro release, and skin permeation were studied.