Coordination Chemistry Regulation Suppressing Voltage Hysteresis for NaMnTi(PO) in High-Rate Sodium-Ion Batteries.

As a natrium superionic conductor, NASICON-type NaMnTi(PO) (NMTP) has garnered increasing attention for large-scale sodium-ion batteries due to its high stability and power densities. Nevertheless, it still suffers from an inferior rate capability and poor cycling longevity, arising from sluggish intrinsic kinetics and severe structural degradation. Herein, vanadium (V) is used as a dopant for equal substitution of manganese (Mn) and titanium (Ti) in NMTP to alleviate voltage hysteresis and enhance the cycling performance.

Electrolyte Regulation toward Cathodes with Enhanced-Performance in Aqueous Zinc Ion Batteries.

Enhancing cathodic performance is crucial for aqueous zinc-ion batteries, with the primary focus of research efforts being the regulation of the intrinsic material structure. Electrolyte regulation is also widely used to improve full-cell performance, whose main optimization mechanisms have been extensively discussed only in regard to the metallic anode. Considering that ionic transport begins in the electrolyte, the modulation of the electrolyte must influence the cathodic performance or even the reaction mechanism.

Prioritisation of functional needs for ICU intelligent robots in China: a consensus study based on the national survey and nominal group technique.

Objective: This study aims to define the prioritisation of the needs for an intelligent robot's functions in the intensive care unit (ICU) from a clinical perspective.

Design: This study introduces a nominal group technique.

Setting: This study uses national setting.

Hierarchical Carbon Interlayer Design as Interfacial Stabilizer and Solid-Electrolyte Infiltrate for High-Performance Solid-State Li-S Batteries.

A great deal of attention has been paid to lithium-sulfur (Li-S) batteries due to their high energy density (>2600 Wh kg), elemental abundance, and environmental friendliness, which show great application prospects in a wide range of energy storage systems. However, the shuttle effect caused by traditional liquid electrolyte remains a problem handicapping the development of the Li-S battery. polymerized gel polymer electrolytes (GPEs) with high ionic conductivity, high-voltage stability, and interfacial compatibility are spotlighted to solve the shuttle effect for better electrochemical performance.

Dynamic Chromatin Accessibility and Transcriptional Regulation in the Eyes of Red Tilapia (Oreochromis sp.) in Response to Wintering Stress.

During wintering, red tilapia may develop variable black spots on their bodies, significantly reducing their market value. Understanding the mechanisms driving this phenomenon is essential for molecular improvements in body color. In this study, we investigated chromatin accessibility landscapes in the eyes of red tilapia with two distinct phenotypes (normal pure red and black spot) under wintering stress using ATAC-seq and RNA-seq analyses.

Dexmedetomidine for delirium prevention in adult patients following cardiac surgery: a meta-analysis of randomized controlled trials.

Objectives: To determine whether perioperative administration of dexmedetomidine reduces the incidence of postoperative delirium in adult patients undergoing cardiac surgery.

Methods: We searched the PubMed, Embase and Cochrane Library databases for randomized controlled trials from the last 10 years up to March 10, 2024. We then conducted a meta-analysis to evaluate the effectiveness and safety of dexmedetomidine in preventing delirium after cardiac surgery in adults.

Elucidating Thermal Decomposition Kinetic Mechanism of Charged Layered Oxide Cathode for Sodium-Ion Batteries.

The safety of the P2-type layered transition metal oxides (P2-NaTMO), a promising cathode material for sodium-ion batteries (SIBs), is a prerequisite for grid-scale energy storage systems. However, previous thermal runaway studies mainly focused on morphological changes resulting from gas production detection and thermogravimetric analysis, while the structural transition and chemical reactions underlying these processes are still unclear. Herein, a comprehensive methodology to unveil an interplay mechanism among phase structures, interfacial microcrack, and thermal stability of the charged P2-NaNiMnO (NNMO) and the P2-NaNiLiMnO (NNMO-Li) at elevated temperatures is established.

Tannic acid-modified FK506-loaded nanoparticles targeting lymph nodes for acute heart transplant rejection treatment.

Significant efforts have been made to deliver immunosuppressants-loaded nanoparticles (NPs) to lymph nodes (LNs) to mitigate transplant rejection. However, conventional administration techniques encounter challenges in enhancing the retention of NPs in the LNs. Attributing the strong affinity of tannic acid (TA) molecules to the elastin of LN conduits, we developed a novel formulation of NPs encapsulating Tacrolimus (FK506), and subsequently modified with TA to produce TA-FNP with a final diameter of approximately 86.

Intravenous dexmedetomidine for delirium prevention in elderly patients following orthopedic surgery: a meta-analysis of randomized controlled trials.

Objectives: We conducted a meta-analysis to investigate the effect of dexmedetomidine on postoperative delirium in elderly orthopedic surgery patients.

Methods: A meta-analysis was conducted to identify randomized controlled trials of dexmedetomidine in elderly patients undergoing orthopedic surgery. The data was published on October 25, 2024.

Tunable Organic-Inorganic p-π-d Electron Conjugation Triggers d-π Hybridization in Quinonized MnO Superlattice toward Ultrastable and High-Rate Zn-MnO Batteries.

Zn-MnO batteries with two-electron transfer harvest high energy density, high working voltage, inherent safety, and cost-effectiveness. Zn as the dominant charge carriers suffer from sluggish kinetics due to the strong Zn-MnO coulombic interaction, which is also the origin of pestilent MnO lattice deformation and performance degradation. Current studies particularly involve H insertion-dominating chemistry, where the long-term cycle stability remains challenging due to the accumulative Zn insertion and structural collapse.

Ecological risk assessment for BDE-47 in marine environment based on species sensitivity distribution method.

BDE-47 is the most abundant and toxic congener in the marine environment. Assessing the ecological risk of BDE-47 in seawater is of great importance to protect the marine species. However, the ecological risks of BDE-47 on marine species is still limited.

Optimal dose and type of exercise improve walking velocity in adults with Parkinson's disease: a systematic review and Bayesian network meta-analysis.

To examine the dose-response relationship between specific types of exercise for improving walking velocity in Parkinson's disease (PD). This systematic review and network meta-analysis included searches of PubMed, Medline, Embase, PsycINFO, Cochrane Library, and Web of Science were searched from inception until February 18th, 2024. Data analysis was performed using R software with the MBNMA and RJAGS packages.

Improvement of Sugar-Free Gummy Jellies' Properties by Phycocyanin Under Ultraviolet (UV) Irradiation.

In this study, (UP) was used as the primary research material, and sugar-free gummy jelly was prepared using ultraviolet (UV) irradiation with phycocyanin. The properties were measured using a texture analyzer, color difference analyzer, low-field nuclear magnetic resonance (LF-NMR) analyzer, and sensory evaluation. Additionally, the stability during accelerated storage was examined.

Identification of cellular signatures associated with chinese hamster ovary cell adaptation for secretion of antibodies.

The secretory capacity of Chinese hamster ovary (CHO) cells remains a fundamental bottleneck in the manufacturing of protein-based therapeutics. Unconventional biological drugs with complex structures and processing requirements are particularly problematic. Although engineered vector DNA elements can achieve rapid and high-level therapeutic protein production, a high metabolic and protein folding burden is imposed on the host cell.

Fast and sensitive multivalent spatial pattern-recognition for circular RNA detection.

While circular RNAs (circRNAs) exhibit lower abundance compared to corresponding linear RNAs, they demonstrate potent biological functions. Nevertheless, challenges arise from the low concentration and distinctive structural features of circRNAs, rendering existing methods operationally intricate and less sensitive. Here, we engineer an intelligent tetrahedral DNA framework (TDF) possessing precise spatial pattern-recognition properties with exceptional sensing speed and sensitivity for circRNAs.

Optimal exercise dose-response improves health-related quality of life in cancer survivors: a systematic review and Bayesian network meta-analysis of RCTs.

Objective: Cancer survivors often face significant health-related quality of life (HRQoL) challenges. Although exercise has been proven to improve HRQoL in cancer survivors, the optimal dose and intensity of exercise for this population has not been fully determined. Adherence to exercise may vary based on exercise intensity, affecting results.

Revisiting astrocytic calcium signaling in the brain.

Astrocytes, characterized by complex spongiform morphology, participate in various physiological processes, and abnormal changes in their calcium (Ca) signaling are implicated in central nervous system disorders. However, medications targeting the control of Ca have fallen short of the anticipated therapeutic outcomes in clinical applications. This underscores the fact that our comprehension of this intricate regulation of calcium ions remains considerably incomplete.

Correlation Between Neutrophil-Lymphocyte Ratio and Inhospital Cardiac Events in Geriatric Patients With Hip Fractures.

The novel inflammatory biomarker known as the neutrophil-lymphocyte ratio (NLR) has shown great potential in predicting and prognosing many diseases. However, its correlation with postoperative inhospital major adverse cardiac events (MACEs) in geriatric patients with hip fractures remains unclear. This study investigated the relationship between NLR and postoperative inhospital MACEs among geriatric patients with hip fractures.

The regulation of the cell cycle and epithelial-mesenchymal transition through FUCA2/GGH signaling promotes the progression of lung adenocarcinoma.

The development of lung adenocarcinoma (LUAD) is intricately linked with cell cycle regulation and epithelial-mesenchymal transition (EMT). Our study, leveraging bioinformatics and database analysis, identified FUCA2 as a key gene influencing the prognosis and progression of LUAD. We observed that FUCA2 is highly expressed in LUAD and correlates with poor outcomes.

Platelet-mimicking nanoparticles loaded with diallyl trisulfide for Mitigating Myocardial Ischemia-Reperfusion Injury in rats.

Hydrogen sulfide (HS) shows promise in treating myocardial ischemia-reperfusion injury (MIRI), but the challenge of controlled and sustained release hinders its clinical utility. In this study, we developed a platelet membrane-encapsulated mesoporous silica nanoparticle loaded with the HS donor diallyl trisulfide (PM-MSN-DATS). PM-MSN-DATS demonstrated optimal encapsulation efficiency and drug-loading content.

Adverse reactions of immune checkpoint inhibitors combined with angiogenesis inhibitors: A pharmacovigilance analysis of drug-drug interactions.

The combination of immune checkpoint inhibitors (ICIs) and angiogenesis inhibitors (AGIs) is widely used in cancer treatment; however, drug-drug reactions (DDIs) remain unknown. We aimed to identify interaction signals for the concomitant use of ICIs and AGIs. Data were obtained from the US FDA Adverse Event Reporting System (FAERS) from January 1, 2015, to December 31, 2023.

Circular RNA SCMH1 suppresses KMO expression to inhibit mitophagy and promote functional recovery following stroke.

Metabolic dysfunction is one of the key pathological events after ischemic stroke. Disruption of cerebral blood flow impairs oxygen and energy substrate delivery, leading to mitochondrial oxidative phosphorylation dysfunction and cellular bioenergetic stress. Investigating the effects of circSCMH1, a brain repair-related circular RNA, on metabolism may identify novel therapeutic targets for stroke treatment.

SSBP1 positively regulates RRM2, affecting epithelial mesenchymal transition and cell cycle arrest in human lung adenocarcinoma cells.

Progression of lung adenocarcinoma (LUAD) is frequently associated with alterations in epithelial-mesenchymal transition (EMT) and cell cycle. Our study analyzed the Cancer Genome Atlas (TCGA) database and identified a positive correlation between high expression of SSBP1 in LUAD tumor tissues and poor prognosis (p < 0.05), with an AUC of 0.

Association of Inflammatory Factors with Cervical Cancer: A Bidirectional Mendelian Randomization.

Purpose: Persistent human papillomavirus infection is thought to be the main cause of the cervical cancer development along with inflammation. However, the potential mechanisms of action of the inflammatory factors in cervical cancer remain unclear. Therefore, this study aimed to assess the relationship between inflammatory factor levels and cervical cancer risk using a two-sample bidirectional Mendelian randomization (MR).