Research status and prospect of flexible optimization design methodology of propeller CNC polishing machines.

Among the components of high-tech ships, the structural complexity of the propeller profile requires a high degree of flexibility in the CNC polishing machine. In addressing this requirement, the study formulates the flexible optimization problem pertaining to research on the propeller CNC polishing machine. A comprehensive analysis is undertaken to scrutinize the geometric features of the propeller and the phenomenon of polished contact.

An Improved Air Health Index Based on Short-Term Cardiovascular Effects in Tianjin, China.

Objectives: To construct an improved air health index (AHI) based on cardiovascular years of life lost (YLL) in Tianjin and assess its utility.

Methods: We derived the exposure-response coefficients from time-series models and calculated the excess YLL (EYLL) for simultaneous exposure to air pollution and non-optimum temperature. The AHI was developed using the EYLL at the WHO 2021 Air Quality Guideline annual mean values and optimum temperature as a reference.

Network pharmacology study and experimental validation of Xiaojianzhong decoction against gastric cancer.

Background: Cancer is one of the most serious threats to human health worldwide. Conventional treatments such as surgery and chemotherapy are associated with some drawbacks. In recent years, traditional Chinese medicine treatment has been increasingly advocated by patients and attracted attention from clinicians, and has become an indispensable part of the comprehensive treatment for gastric cancer.

Palladium-catalyzed regioselective carbonylation of 2-amino-2,3-diphenylpropanoate to 5/6-membered benzolactams.

Five/six-membered benzolactams are significant blocks in both organic and medicinal chemistry. Achieving 5/6-membered benzolactams from the same starting compound under varying reaction conditions presents a significant challenge. Herein, palladium-catalyzed free amine-oriented regioselective C-H activations/carbonylations mediated by hexacarbonylmolybdenum, leading to diverse sizes of benzolactams, respectively, have been developed.

3D Covalent Organic Framework Membranes for Molecular Separations.

Membrane separation has become an indispensable separation technology in social production, playing an important role in drug production, mineral exploitation, water purification, etc. The key core of membranes lies in achieving efficient and precise sieving between substances. As a result, a typical trade-off arises: highly permeable membranes usually sacrifice selectivity and vice versa.

Biomineralized ZIF-8 Encapsulating SOD from Hydrogenobacter Thermophilus: Maintaining Activity in the Intestine and Alleviating Intestinal Oxidative Stress.

Oxidative stress is a major factor leading to inflammation and disease occurrence, and superoxide dismutase (SOD) is a crucial antioxidative metalloenzyme capable of alleviating oxidative stress. In this study, a novel thermostable SOD gene is obtained from the Hydrogenobacter thermophilus strain (HtSOD), transformed and efficiently expressed in Escherichia coli with an activity of 3438 U mg, exhibiting excellent thermal stability suitable for scalable production. However, the activity of HtSOD is reduced to less than 10% under the acidic environment.

A multi-center, randomized, double-blind, sham-stimulation controlled study of transcranial magnetic stimulation with precision navigation for the treatment of multiple system atrophy.

Background: Multiple system atrophy (MSA) is recognized as an atypical Parkinsonian syndrome, distinguished by a more rapid progression than that observed in Parkinson's disease. Unfortunately, the prognosis for MSA remains poor, with a notable absence of globally recognized effective treatments. Although preliminary studies suggest that transcranial magnetic stimulation (TMS) could potentially alleviate clinical symptoms in MSA patients, there is a significant gap in the literature regarding the optimal stimulation parameters.

Resequencing reveals population structure and genetic diversity in Tibetan sheep.

Background: The Tibetan sheep is one of the three major primitive sheep breeds in China, representing a unique and high-quality genetic resource in the Qinghai-Tibet Plateau and neighboring high-altitude regions, exhibiting exceptional adaptability to high-altitude climatic environments. However, research on the genetic relationships among different populations of Tibetan sheep at the whole-genome level remains insufficient. This study aims to explore the population structure and historical dynamics among 11 Tibetan sheep populations, accurately assess the genetic diversity within the populations, and providing a theoretical basis for the development of targeted genetic breeding strategies for Tibetan sheep.

Synthesis and performance evaluation of polymer-ceramic composite microcapsules as reservoir protectant for natural gas hydrate drilling.

Natural gas hydrate is a promising unconventional natural gas source due to its high energy density and huge global reserves. During exploitation, the drilling fluid may invade the hydrate formation and induce hydrate decomposition, causing reservoir damage. Herein, a novel reservoir protectant made by bio-degradable temporary plugging material (BDTPM) was developed in the form of polymer-ceramic composite microcapsules.

Time and dose selective glucose metabolism for glucose homeostasis and energy conversion in the liver.

Hepatic glucose metabolism serves dual purposes: maintaining glucose homeostasis and converting glucose into energy sources; however, the underlying mechanisms are unclear. We quantitatively measured liver metabolites, gene expression, and phosphorylated insulin signaling molecules in mice orally administered varying doses of glucose, and constructed a transomic network. Rapid phosphorylation of insulin signaling molecules in response to glucose intake was observed, in contrast to the more gradual changes in gene expression.

Diversity and community distribution of soil bacterial in the Yellow River irrigation area of Ningxia, China.

The bacterial community performs an essential ecological role in maintaining agriculture systems. The roles of bacteria in the forest, marine, and agricultural systems have been studied extensively and intensively. However, similar studies in the areas irrigated by the Yellow River remain limited.

Plasma-activated medium exerts tumor-specific inhibitory effect on hepatocellular carcinoma via disruption of the salvage pathway.

Hepatocellular carcinoma has high fatality and poor prognosis. For curing hepatocellular carcinoma, the demand for effective therapeutic reagents with low toxicity is urgent. Herein, we investigated plasma-activated medium, an emerging reagent obtained via irradiation of cell-free medium with cold atmospheric plasma.

[Experts consensus on standard items of the cohort construction and quality control of temporomandibular joint diseases (2024)].

Temporomandibular joint (TMJ) diseases are common clinical conditions. The number of patients with TMJ diseases is large, and the etiology, epidemiology, disease spectrum, and treatment of the disease remain controversial and unknown. To understand and master the current situation of the occurrence, development and prevention of TMJ diseases, as well as to identify the patterns in etiology, incidence, drug sensitivity, and prognosis is crucial for alleviating patients'suffering.

ANAgdb: a multi-omics and taxonomy database for ANA-grade.

Background: The ANA-grade, encompassing early-diverging angiosperm lineages, Amborellales, Nymphaeales, and Austrobaileyales, represents a fundamental phase in the evolutionary history of flowering plants. Since the completion of key assembly of the Amborella genome, the continuous influx of omics data from the lineage underscores the need for a specialized database.

Results: Here, we introduce the ANA-grade Genome Database (ANAgdb, https://anagenome.

Neuronal LAMP2A-mediated reduction of adenylyl cyclases induces acute neurodegenerative responses and neuroinflammation after ischemic stroke.

Lysosomes regulate cellular metabolism to maintain cell survival, but the mechanisms whereby they determine neuronal cell fate after acute metabolic stress are unknown. Neuron-enriched lysosomal membrane protein LAMP2A is involved in selective chaperone-mediated autophagy and exosome loading. This study demonstrates that abnormalities in the neuronal LAMP2A-lysosomal pathway cause neurological deficits following ischemic stroke and that this is an early inducer of the PANoptosis-like molecular pathway and neuroinflammation, simultaneously inducing upregulation of FADD, RIPK3, and MLKL after ischemia.

Nutrients, Diet Quality, and Dietary Patterns in Patients with Inflammatory Bowel Disease: A Comparative Analysis.

(1) Background: Diet plays an important role in the development of inflammatory bowel disease (IBD). There are a number of methods available to assess the diets of patients with IBD, including nutrients, dietary patterns, and various appraisal tools of diet quality. However, research on diet quality and dietary patterns in IBD populations is limited, and comparative evaluations of dietary intake in patients with IBD have not been performed.

YOLO-BFRV: An Efficient Model for Detecting Printed Circuit Board Defects.

The small area of a printed circuit board (PCB) results in densely distributed defects, leading to a lower detection accuracy, which subsequently impacts the safety and stability of the circuit board. This paper proposes a new YOLO-BFRV network model based on the improved YOLOv8 framework to identify PCB defects more efficiently and accurately. First, a bidirectional feature pyramid network (BIFPN) is introduced to expand the receptive field of each feature level and enrich the semantic information to improve the feature extraction capability.

Design and Analysis of a Hand-Held Surgical Forceps with a Force-Holding Function.

Physiological hand tremors, twitching, and the nonlinear characteristics of the relationship between surgical forceps clamping force and operating force seriously affect the clamping accuracy of surgical instruments. To address this problem, a new type of surgical forceps with a force-holding function was developed to replace traditional forceps, which was studied in terms of structural design, statics, and dynamics. The overall structure of the surgical forceps was designed based on the lever principle, the kinematic model of the clamping part of the surgical forceps was established by the geometrical method, and the correctness of the kinematic model was verified by ADAMS.

In Vitro Antimicrobial Synergistic Activity and the Mechanism of the Combination of Naringenin and Amikacin Against Antibiotic-Resistant .

Bacterial drug resistance is becoming an increasingly serious problem, and the development of antibacterial synergists is urgently needed. Combining existing antibiotics with promising nonantibiotic agents is one strategy that has been shown to be effective at overcoming the widespread emergence of antibiotic-resistant pathogens. In this study, we investigated the antibacterial activities and mechanism of naringenin (NG) combined with amikacin (AMK) against multidrug-resistant ().

Integration of Transcriptomics and WGCNA to Characterize -Induced Systemic Resistance in for Defense against .

Beneficial fungi of the genus are among the most widespread biocontrol agents that induce a plant's defense response against pathogens. is one of the main pathogens that can negatively affect production and quality. To investigate the impact of on defense responses to , roots under + (T + F) treatment and (F) treatment were sampled and subjected to transcriptomic analysis.

Chitosan-Modified AgNPs Efficiently Inhibit Swine Coronavirus-Induced Host Cell Infections via Targeting the Spike Protein.

The COVID-19 pandemic, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has filled a gap in our knowledge regarding the prevention of CoVs. Swine coronavirus (CoV) is a significant pathogen that causes huge economic losses to the global swine industry. Until now, anti-CoV prevention and control have been challenging due to the rapidly generated variants.