Histone Deacetylase 7-Derived 7-Amino Acid Peptide Increases Skin Wound Healing via Regulating Epidermal Fibroblast Proliferation and Migration.

Due to the complexity of wound healing, how to achieve successful healing is a significant clinical challenge. In this study, we found that the histone deacetylase-7-derived 7-amino acid peptide (7A, MHSPGAD), especially its phosphorylated version 7Ap (MH[pSer]PGAD), increased dermal fibroblast cell HDFα proliferation and migration via elevated delta-catenin (CTNND1) serine phosphorylation-mediated beta-catenin (CTNNB) nuclear translocation and subsequent upregulation of c-Myc and cyclin D1 expression. 7Ap physically interacted with platelet-derived growth factor receptor (PDGFR) and increased PDGFR interaction with cyclin-dependent kinase 6 (CDK6).

Transparent, Flexible, Responsive Switching "Delayed" Amphiphilic Coatings Designed on the Basis of the Full-Cycle Antifouling Strategy.

Marine fouling on the surface of ships and equipment not only creates problems of enhanced resistance to navigation and increased energy consumption but also leads to unclear vision and inaccurate data collection. Antifouling coatings to resist fouling are effective, but it is difficult to achieve long-lasting fouling protection with a single interface state. Switching the status of the interface by intelligent response is a reasonable way to achieve full-cycle efficient antifouling.

Achieving Record CH Packing Density for Highly Efficient CH/CH Separation with a Metal-Organic Framework Prepared by a Scalable Synthesis in Water.

Adsorptive CH/CH separation using metal-organic frameworks (MOFs) has emerged as a promising technology for the removal of CH (acetylene) impurity (1 %) from CH (ethylene). The practical application of these materials involves the optimization of separation performance as well as development of scalable and green production protocols. Herein, we report the efficient CH/CH separation in a MOF, Cu(OH)INA (INA: isonicotinate) which achieves a record CH packing density of 351 mg cm at 0.

Efficacy and safety of apatinib plus immune checkpoint inhibitors and transarterial chemoembolization for the treatment of advanced hepatocellular carcinoma.

Purpose: The evidence of apatinib plus immune checkpoint inhibitors (ICIs) and transarterial chemoembolization (TACE) for treating advanced hepatocellular carcinoma (HCC) is limited. This study aimed to compare the treatment efficacy and safety of apatinib plus ICIs and TACE with apatinib plus TACE in these patients.

Methods: This study retrospectively enrolled 90 patients with advanced HCC treated with apatinib plus TACE (A-TACE group, n = 52) or apatinib plus ICIs and TACE (IA-TACE group, n = 38).

IL-27 Gene Therapy Ameliorates IPEX Syndrome Caused by Germline Mutation of Foxp3 Gene: A Major Role for Induction of IL-10.

Inactivating mutations of Foxp3, the master regulator of regulatory T cell development and function, lead to immune dysregulation, polyendocrinopathy, enteropathy, X-linked (IPEX) syndrome in mice and humans. IPEX is a fatal autoimmune disease, with allogeneic stem cell transplant being the only available therapy. In this study, we report that a single dose of adeno-associated virus (AAV)-IL-27 to young mice with naturally occurring Foxp3 mutation (Scurfy mice) substantially ameliorates clinical symptoms, including growth retardation and early fatality.

Recovery of High-Purity SF from Humid SF/N Mixture within a Co(II)-Pyrazolate Framework.

Sulfur hexafluoride (SF) is extensively employed in the power industry. However, its emissions significantly contribute to the greenhouse effect. The direct recovery of high purity SF from industrial waste gases would benefit its sustainable use, yet this represents a considerable challenge.

Ultrasonic in-situ reduction preparation of SBA-15 loaded ultrafine RuCo alloy catalysts for efficient hydrogen storage of various LOHCs.

SBA-15-loaded RuCo alloy nanoparticle catalysts (RuCo/S15-SU) for the efficient catalysis of hydrogen storage by various liquid organic hydrogen carriers (LOHCs) were prepared via strong electrostatic adsorption (SEA)-ultrasonic in-situ reduction (UR) technology. The above prepared catalysts were subjected to a series of characterization, such as XPS, H-TPD/TPR, N adsorption-desorption, ICP, CO-chemisorption, FT-IR, XRD and TEM. Ru and Co were evenly anchored on the surface of SBA-15 by SEA, and ultrafine RuCo alloy nanoparticles were formed by UR without any chemical reducing or stabilizing agents.

Evaluation of Open-Source Large Language Models for Metal-Organic Frameworks Research.

Along with the development of machine learning, deep learning, and large language models (LLMs) such as GPT-4 (GPT: Generative Pre-Trained Transformer), artificial intelligence (AI) tools have been playing an increasingly important role in chemical and material research to facilitate the material screening and design. Despite the exciting progress of GPT-4 based AI research assistance, open-source LLMs have not gained much attention from the scientific community. This work primarily focused on metal-organic frameworks (MOFs) as a subdomain of chemistry and evaluated six top-rated open-source LLMs with a comprehensive set of tasks including MOFs knowledge, basic chemistry knowledge, in-depth chemistry knowledge, knowledge extraction, database reading, predicting material property, experiment design, computational scripts generation, guiding experiment, data analysis, and paper polishing, which covers the basic units of MOFs research.

Preparation and Application of Apatite-TiO Composite Opacifier: Preventing Titanium Glaze Yellowing through Pre-Combination.

In order to enhance the degree of binding reaction of TiO in titanium-containing ceramic glazes and prevent the reaction of its transformation into rutile to eliminate the yellowing phenomenon of the glaze surface, an apatite-TiO composite opacifier (ATO) was prepared through the mechanical grinding of hydroxyapatite and anatase TiO. The properties, opacification mechanism, and yellowing inhibition of the prepared ceramic glazes were studied. The results show that the ATO is characterized by a uniform coating of TiO on the surface of the apatite and the formation of close chemical bonding between the apatite and TiO.

Therapeutic Immunomodulation in Gastric Cancer.

Gastric carcinoma, being one of the most prevalent types of solid tumors, has emerged as the third leading cause of death worldwide. The symptoms of gastric cancer (GC) are typically complex, which makes early detection challenging. Immune checkpoint inhibition has become the new standard targeted therapy for advanced or metastatic GC.

Ultrasound-assisted preparation of PdCo bimetallic nanoparticles loaded on beta zeolite for efficient catalytic hydrogen production from dodecahydro-N-ethylcarbazole.

Research and development of high-performance catalysts is a key technology to realize hydrogen energy storage and transportation based on liquid organic hydrogen carriers. Co/beta was prepared using beta zeolite as a carrier via an electrostatic adsorption (ESA)-chemical reduction method, and it was used as the template and reducing agent to prepare bimetallic catalysts via an ultrasonic assisted galvanic replacement process (UGR). The fabricated PdCo/beta were characterized by TEM, XPS, FT-IR, XRD, H-TPR, and H-TPD.

IL-27 in combination with anti-PD-1 can be anti-cancer or pro-cancer.

Interleukin-27 (IL-27) is known to play opposing roles in immunology. The present paper considers, specifically, the role IL-27 plays in cancer immunotherapy when combined with immune checkpoint inhibitor anti-PD-1. We first develop a mathematical model for this combination therapy, by a system of Partial Differential Equations, and show agreement with experimental results in mice injected with melanoma cells.

New insights into the downregulation of cytochrome P450 2E1 via nuclear factor κB-dependent pathways in immune-mediated liver injury.

The extent of immune-mediated hepatic damage (such as in viral hepatitis) is characterised by the downregulation of cytochrome P450s (CYPs), a class of drug-metabolising enzymes. However, whether this downregulation aids liver cells in maintaining their homeostasis or whether the damage is aggravated remains largely unexplored. Herein, we evaluated the effects of phosphorylation mediated by the protein kinase C (PKC)/cAMP-response element binding protein (CREB) and nitration mediated by inducible nitric oxide synthase (iNOS) on the downregulation of CYP2E1 during immune-mediated liver injury.

Microbiota Alters and Its Correlation with Molecular Regulation Underlying Depression in PCOS Patients.

Depression is one of the complications in patients with polycystic ovary syndrome (PCOS) that leads to considerable mental health. Accumulating evidence suggests that human gut microbiomes are associated with the progression of PCOS and depression. However, whether microbiota influences depression development in PCOS patients is still uncharacterized.

Hippophae rhamnoides reverses decreased CYP2D6 expression in rats with BCG-induced liver injury.

In this study, we investigated the effect of Hippophae rhamnoides L. (HRP) on the activity of CYP2D6 via the CAMP/PKA/NF-κB pathway in rats with Bacille Calmette-Guerin (BCG)-induced immunological liver injury. BCG (125 mg/kg) was injected to establish the rat model of liver injury.

AgingReG: a curated database of aging regulatory relationships in humans.

Aging and cellular senescence are characterized by a progressive loss of physiological integrity, which could be triggered by aging factors such as physiological, pathological and external factors. Numerous studies have shown that gene regulatory events play crucial roles in aging, increasing the need for a comprehensive repository of regulatory relationships during aging. Here, we established a manually curated database of aging factors (AgingReG, https://bio.

TSHR-based chimeric antigen receptor T cell specifically deplete auto-reactive B lymphocytes for treatment of autoimmune thyroid disease.

Graves' disease (GD) is a prominent antibody-mediated autoimmune disorder characterized by stimulating antibodies (TRAb) that target the thyroid-stimulating hormone receptor (TSHR). Targeting and eliminating TRAb-producing B lymphocytes hold substantial therapeutic potential for GD. In this study, we engineered a novel chimeric antigen receptor T cell (CAR-T) therapy termed TSHR-CAR-T.

Preparation of Ni@Pd Core-Shell Nanoparticles Supported on KIT-6 by Ultrasound-Assisted Galvanic Replacement for Dodecahydro--ethylcarbazole Dehydrogenation.

Using Ni as a template and reductant, Ni core-Pd shell nanoparticles (Ni@Pd NPs) supported on KIT-6 (Ni@Pd/K6) were prepared by a galvanic replacement reaction under ultrasonic radiation. The characterization results show that the Ni@Pd core-shell NPs with an average diameter of 1.9 ± 0.

Preparation of SBA-15 supported Ru nanocatalysts by electrostatic adsorption-ultrasonic in situ reduction method and its catalytic performance for hydrogen storage of N-ethylcarbazole.

N-ethylcarbazole (NEC) is an ideal liquid organic hydrogen storage carrier. The development of efficient hydrogen storage catalysts can promote the large-scale application of this process. In this paper, SBA-15 supported Ru nanocatalysts (Ru/S15-SU) were synthesized by strong electrostatic adsorption (SEA)-ultrasonic in situ reduction method (UR).

ANXA13 promotes cell proliferation and invasion and attenuates apoptosis in renal cell carcinoma.

Purpose: Emerging evidences have demonstrated that annexin A13 (ANXA13) is closely related to the occurrence and development of malignant tumors. However, the functions and underlying molecular mechanisms of ANXA13 in Clear cell renal cell carcinoma (ccRCC) have not been defined. Therefore, this study aimed to clarify the potential role of ANXA13 in regulating the proliferation, migration, invasion, cell cycle, and apoptosis of ccRCC cells.

IL-27 Gene Therapy Induces Stat3-Mediated Expansion of CD11b+Gr1+ Myeloid Cells and Promotes Accumulation of M1 Macrophages in the Tumor Microenvironment.

IL-27 is a pleiotropic cytokine that exhibits stimulatory/regulatory functions on multiple lineages of immune cells and has a potential to be used as a therapeutic for cancer. We have recently demonstrated that administration of IL-27 producing adeno-associated virus (AAV-IL-27) exhibits potent inhibition of tumor growth in mouse models. In this study, we demonstrate that AAV-IL-27 treatment leads to significant expansion of CD11b+Gr1+ myeloid cells.