Surfactant-modified zein nanoparticles adsorbents for ultrafast and efficient removal of Cr(VI).

The adsorption and removal of heavy metal ions Cr(VI) is of great significance for human health and ecological environment. Here, an ultrafast and high efficient adsorbent for Cr(VI) was developed based on cetyltrimethylammonium bromide (CTAB)-modified zein nanoparticles (C-ZNPs). In comparison to pristine zein nanoparticles (ZNPs) (11.

Revolutionizing animal husbandry: Breakthroughs in gene editing delivery systems.

Gene editing technology has become an essential tool for advancing breeding practices, enhancing disease resistance, and boosting productivity in animal husbandry. Despite its potential, the delivery of gene editing reagents into cells faces several challenges, including low targeting efficiency, immunogenicity, and cytotoxicity, which have hindered its wider application in the field. This review discusses the evolution of gene editing technologies and highlights recent advancements in various delivery methods used in animal husbandry.

Low polarity fraction of Radix Bupleuri alleviates chronic unpredictable mild stress-induced depression in rats through FXR modulating bile acid homeostasis in liver, gut, and brain.

Radix Bupleuri (BR, Bupleurum chinense DC.) is a well-known traditional Chinese medicine (TCM) known for its effects on soothing the liver and alleviating depression, and is widely used in clinical settings to manage depressive symptoms. A dosage of 12.

Sustainable photocatalytic hydrogen peroxide production over octonary high-entropy oxide.

The direct utilization of solar energy for the artificial photosynthesis of hydrogen peroxide (HO) provides a reliable approach for producing this high-value green oxidant. Here we report on the utility of high-entropy oxide (HEO) semiconductor as an all-in-one photocatalyst for visible light-driven HO production directly from HO and atmospheric O without the need of any additional cocatalysts or sacrificial agents. This high-entropy photocatalyst contains eight earth-abundant metal elements (Ti/V/Cr/Nb/Mo/W/Al/Cu) homogeneously arranged within a single rutile phase, and the intrinsic chemical complexity along with the presence of a high density of oxygen vacancies endow high-entropy photocatalyst with distinct broadband light harvesting capability.

Trade-off strategies for driving the toxicity and metabolic remodeling of copper oxide nanoparticles and copper ions in Ipomoea aquatica.

The ecological safety of copper oxide nanoparticles (CuO NPs) in the environment determines the advancement of nano-agriculture owing to breakthroughs in nanotechnology; however, the release of Cu is an uncontrollable factor. Currently, the trade-off mechanisms of CuO NPs and Cu dominating the potential hazards of plant-nano systems remain unclear. This study proposed the trade-off strategy for reconstructing physiological responses and metabolic profiles and deciphered the differential regulation of dominant CuO NPs and Cu in plants.

Direct colour printing on zirconia using 222 nm UV-C photons.

Objectives: To proof the feasibility of direct colour printing on 3Y-TZP using 222 nm UV-C through investigating the degree and durability of the colour changes, and testifying whether surface, mechanical and biological properties are influenced by the treatment.

Methods: 222 nm UV-C light (Irradiance: 1.870 mW/cm) was used to treat 3Y-TZP for durations from 15 min to 24 h.

Spatial organization of PI3K-PI(3,4,5)P-AKT signaling by focal adhesions.

The class I phosphatidylinositol 3-kinase (PI3K)-AKT signaling pathway is a key regulator of cell survival, growth, and proliferation and is among the most frequently mutated pathways in cancer. However, where and how PI3K-AKT signaling is spatially activated and organized in mammalian cells remains poorly understood. Here, we identify focal adhesions (FAs) as subcellular signaling hubs organizing the activation of PI3K-PI(3,4,5)P-AKT signaling in human cancer cells containing p110α mutations under basal conditions.

Enhancing Water Lubrication in UHMWPE Using Mesoporous Polydopamine Nanoparticles: A Strategy to Mitigate Frictional Vibration.

Establishing a persistent lubrication mechanism and a durable tribo-film on contact surfaces is identified as crucial for improving the tribology and vibration characteristics of polymer materials under water-lubricated conditions. This study focuses on enhancing tribological performance and reducing frictional vibrations in ultrahigh molecular weight polyethylene (UHMWPE) through the incorporation of mesoporous polydopamine (MPDA) nanoparticles. In the experiments, MPDA nanoparticles were synthesized and blended with UHMWPE to create UHMWPE/MPDA composites.

Federated Learning for Predicting Postoperative Remission of Patients with Acromegaly: A Multicentered Study.

Background: Decentralized federated learning (DFL) may serve as a useful framework for machine learning (ML) tasks in multicentered studies, maximizing the use of clinical data without data sharing. We aim to propose the first workflow of DFL for ML tasks in multicentered studies, which can be as powerful as those using centralized data.

Methods: A DFL workflow was developed with 4 steps: registration, local computation, model update, and inspection.

Symptomology of celiac artery compression: Classifying patients by the degree of celiac artery stenosis and secondary changes in collateral branches on computed tomography angiogram.

Purpose: This study aimed to analyze the correlation between the degree of celiac artery (CA) stenosis and the secondary changes in collateral branches in patients with CA compression (CAC) by CT and to classify patients by the combination of the two imaging features.

Methods: Patients with CAC identified by contrast-enhanced CT from January 2012 to December 2013 were retrospectively enrolled and divided into the symptomatic group and asymptomatic group. CA stenosis was categorized as mild, moderate, or severe, and collateral circulation as invisible, visible, or prominent.

Response mechanisms of Annual bluegrass (Poa annua) to cold, drought, combined stresses and recovery in morphology, photosynthesis, physiology and microstructure.

Drought and cold stresses co-occur in nature, and significantly limited agricultural productivity in northwest China. Their effects on plant photosynthesis, physiology and biochemistry, and microstructure have been extensively studied, but their combined stress mechanisms remain unclear. Therefore, growth chamber experiments were conducted using the Annual bluegrass (Poa annua) with the 'HZ' and 'ZQ' germplasms, our goal was to clarify the responses of leaves to cold (C), drought (D), and combined (D&C) stresses in the morphology, photosynthesis, physiology and biochemistry, and microstructure.

Wine polyphenol oxidation mechanism and the effects on wine quality: A review.

Over the last few decades, there has been considerable interest in studying wine oxidation. This review paper provides a comprehensive overview and analysis of the molecular changes caused by oxidation in wine and how they affect wine quality. Simultaneously, the recent advancements in understanding the molecular pathways involved in wine oxidation are also discussed.

Quantifying the Fascicular Changes in Recovered Achilles Tendon Patients Using Diffusion Magnetic Resonance Imaging and Tractography.

Regardless of the way of treatment, persistent deficits in calf muscles in recovered patients from Achilles tendon rupture (ATR) exist long-term postinjury. Studies on calf muscle changes mostly highlight morphological changes in the calf muscles and Achilles tendon. However, limited attention has been given to fascicular changes.

Superprotonic Conductivity of Guanidinium Organosulfonate Hydrogen-Bonded Organic Frameworks with Nanotube-Shaped Proton Transport Channels.

Grasping proton transport pathways and mechanisms is vital for the application of fuel cell technology. Herein, we screened four guanidinium organosulfonate charge-assisted hydrogen-bonded organic frameworks (HOFs), namely, , , , and , which possess high hydrogen-bonded density proton transport networks shaped like nanotubes. These materials were prepared by self-assembly through charge-assisted interactions between guanidinium cations and organosulfonate anions, as well as by host-guest regulation.

Application prospects of urine-derived stem cells in neurological and musculoskeletal diseases.

Urine-derived stem cells (USCs) are derived from urine and harbor the potential of proliferation and multidirectional differentiation. Moreover, USCs could be reprogrammed into pluripotent stem cells [namely urine-derived induced pluripotent stem cells (UiPSCs)] through transcription factors, such as octamer binding transcription factor 4, sex determining region Y-box 2, kruppel-like factor 4, myelocytomatosis oncogene, and Nanog homeobox and protein lin-28, in which the first four are known as Yamanaka factors. Mounting evidence supports that USCs and UiPSCs possess high potential of neurogenic, myogenic, and osteogenic differentiation, indicating that they may play a crucial role in the treatment of neurological and musculoskeletal diseases.

Exploring the Regulatory Interaction of Differentially Expressed Proteins in Cleft Palate Induced by Retinoic Acid.

Objective: This study aimed to identify novel proteins involved in retinoic acid (RA)-induced embryonic cleft palate development.

Method: The palate tissues of the control and RA-treated E14.5 were dissected and subjected to iTRAQ-based proteomic analysis.

Preparation of chitosan derivatives/oxidized carboxymethyl cellulose hydrogels by freeze-thaw method: Synthesis, characterization, and utilization in dye absorption.

This study successfully synthesized hydrogels by modifying chitosan with water-soluble and carboxyethyl groups, followed by crosslinking with oxidized carboxymethyl cellulose (OCMC). Structural analyses substantiated the establishment of robust imine linkages between the amino and aldehyde groups, affirming the hydrogel's architecture. Using scanning electron microscopy and texture analysis, it was observed that incorporating water-soluble chitosan significantly increased the hydrogel's porosity and hardness.

Effect of traditional Chinese medicine therapy on labor pain in patients with natural childbirth: A network meta-analysis.

Background: This systematic review compared the efficacy of traditional Chinese medicine (TCM) treatments for outcomes of different stages and labor pain among pregnant women.

Methods: Eight databases were electronically searched for TCM on labor pain between January 2012 and January 2022. The studies were recorded and screened according to inclusion criteria and subsequently entered in Note Express.

Integrative 3D genomics with multi-omics analysis and functional validation of genetic regulatory mechanisms of abdominal fat deposition in chickens.

Chickens are the most abundant agricultural animals globally, with controlling abdominal fat deposition being a key objective in poultry breeding. While GWAS can identify genetic variants associated with abdominal fat deposition, the precise roles and mechanisms of these variants remain largely unclear. Here, we use male chickens from two lines divergently selected for abdominal fat deposition as experimental models.

Biochar affects soil properties over 1 m depth in an alkaline soil of north China Plain.

Biochar has been shown to enhance soil quality and agricultural yields. Previous studies about biochar's effect on soil properties mainly concentrated on the top 30 cm layer but less on the subsoils. Given the subsoil's active role in climate change mitigation and its significance for nutrient cycling and crop productivity, understanding biochar's effects at depth is crucial.

Porcine reproductive and respiratory syndrome virus nonstructural protein 2 promotes the autophagic degradation of adaptor protein SH3KBP1 to antagonize host innate immune responses by enhancing K63-linked polyubiquitination of RIG-I.

Non-structural protein 2 (NSP2) of PRRSV is highly variable and plays crucial roles in the virus's life cycle. To elucidate the function of NSP2 during PRRSV infection, we identified SH3KBP1 as an NSP2-interacting host protein using mass spectrometry. Exogenous SH3KBP1 expression significantly inhibited PRRSV replication by enhancing IFN-I and related ISGs production.

Effect of elevated CEA levels on the outcome of colorectal cancer patients with different histopathologic types: A SEER population-based study.

Limited and contradictory evidence has been reported regarding the prognostic effects of carcinoembryonic antigen (CEA) on the prognosis and metastasis of classical adenocarcinoma (CA), mucinous adenocarcinoma (MA), and signet-ring cell carcinoma (SRCC) in colorectal cancer patients. We investigated the associations between histological subtypes and preoperative serum CEA levels in determining the oncologic outcomes of colorectal cancer (CRC) patients. A total of 47,692 patients with clearly diagnosed CRC were selected from the Surveillance, Epidemiology, and End Results (SEER) database and divided into two cohorts based on serum CEA levels: CEA-normal (C0) and CEA-elevated (C1).