Different effects of super-chilling and chilling storage on pork spoilage: Insights from dynamic microbial community changes and metabolic profiles.

Super-chilling can extend the shelf life of high-oxygen modified atmosphere packaged (MAP) pork from 14 to 56 days compared to conventional chilling storage. The spoilage of raw pork may result from the growth of microorganisms, which ultimately release undesirable metabolites. To investigate this, the microbial and metabolic characteristics of super-chilled MAP pork were determined using 16S rRNA sequencing and untargeted metabolomics based on UHPLC-MS/MS.

Combination of Dynamic and Permanent Cross-Linking: A Pathway to Enhance Elasticity and Recyclability.

Thermosetting materials exhibit advantages such as dimensional stability and elasticity but lack reprocessability due to their permanently cross-linked internal structure. Introducing a reversible cross-linked network endows materials with reprocessability but often compromises resilience and mechanical properties. Hence, it is still a significant challenge to develop recyclable elastomers with high elasticity as traditional thermosetting materials and remolding ability as traditional thermoplastic materials.

In vitro screening of synbiotics composed of Lactobacillus and oligosaccharides and evaluating the potential anti-allergic ability.

Studies have demonstrated that the supplementation of oligosaccharides and Lactobacillus has the potential to alleviate food allergies. In this study, the gastrointestinal tolerance and adhesion properties of three anti-allergic Lactobacillus strains were evaluated in vitro. Subsequently, five oligosaccharides were incubated with each selected Lactobacillus strain to determine which combination could significantly promote Lactobacillus proliferation.

Catalytic Oxidative Valorization of Biobased 5-Hydroxymethylfurfural over Multi-ligand Functionalized Polyoxovanadates.

The oxidative conversion of 5-hydroxymethylfurfural (HMF) to 2,5-diformylfuran (DFF) is an important reaction for the utilization of biomass resources. This process has garnered considerable research attention in both industry and academia, yet it still presents considerable challenges. To achieve an effective and mild oxidative upgrade of the HMF molecule, a multiorganic-ligand-functionalized polyoxovanadate catalyst, VO(OCH)(mIM)(CHPO) (), has been successfully prepared by using both oxygen- and nitrogen-containing ligands.

The formation pathway of flavor compounds in steamed Antarctic krill () based on untargeted metabolomics.

This study investigated the impact of steaming on the flavor and metabolic profile of Antarctic krill, aiming to elucidate the pathways responsible for flavor development and metabolic shifts during processing. HS-SPME-GC-MS identified key volatile compounds, including alcohols, aldehydes, ketones and so on. The results demonstrated a significant increase in nonanal content from 2.

Progress in research on the formation mechanism, chemical composition, pharmacological effects, and clinical applications of Musk: A Review.

Ethnopharmacological Relevance: Moschus (Musk), a precious zoogenous medicinal material in traditional Chinese medicine (TCM), has been extensively utilized for centuries with well-documented therapeutic efficacy. It has important medicinal and economic value and is derived from the secretions of the scent gland sacs of male musk deer, which are dried and solidified under specific physiological conditions. Contemporary pharmacological investigations have validated its multifaceted pharmacological activities, including but not limited to anti-inflammatory, antioxidant, antitumor, and neuroregulatory effects, thereby substantiating its unique therapeutic status in the TCM pharmacopoeia.

Super Bending-Stable Flexible Colloidal QD Photodetector with Fast Response and Near-Unity Carrier Extraction Efficiency.

Flexible colloidal quantum dot (QD) optoelectronics apply the superior properties of colloidal QDs to flexible devices, exhibiting unique advantages in the fields of imagers, solar cells, displays, wearable sensors, on-skin electronics, robotics, and bioimaging. Here, we show that colloidal QD photodiodes (QDPDs) with an ultrathin QD absorber layer have record bending stability with 100,000 repetitive bending cycles in QD devices. The QDPDs obtained a high-quality p-n junction with a 1700 rectification ratio.

Single-cell transcriptomics reveals the multidimensional dynamic heterogeneity from primary to metastatic gastric cancer.

Reprogramming of the tumor microenvironment (TME) plays a critical role in gastric cancer (GC) progression and metastasis. However, the multidimensional features between primary tumors and organ-specific metastases remain poorly understood. In this study, we characterized the dynamic heterogeneity of GC from primary to metastatic stages.

BRD1 deficiency affects SREBF1-related lipid metabolism through regulating H3K9ac/H3K9me3 transition to inhibit HCC progression.

BRD1 encodes a protein containing a bromodomain, which is an essential component of histone acetyltransferase (HAT) complexes. These complexes play a crucial role in the regulation of gene transcription and the modification of chromatin structures. The aberrant expression of BRD1 is frequently observed across a range of cancer types, including hepatocellular carcinomas (HCC).

Neoadjuvant apatinib addition to sintilimab and carboplatin-taxane based chemotherapy in patients with early triple-negative breast cancer: the phase 2 NeoSAC trial.

We aimed to evaluate the efficacy and safety of adding apatinib, to sintilimab and chemotherapy in the neoadjuvant treatment of early triple-negative breast cancer (TNBC). In the phase 2 NeoSAC trial, patients with early TNBC received six cycles of apatinib, sintilimab, nab-paclitaxel, and carboplatin followed by surgery. The primary endpoint was pathological complete response (pCR) rate.

Analysis on scattering and inner near-field characteristics of a uniaxial anisotropic sphere by an off-axis high-order Bessel (vortex) beam.

Based on the generalized Lorenz-Mie theory (GLMT) and the Fourier transform method, a theoretical approach is introduced to study the scattering of a uniaxial anisotropic sphere illuminated by an off-axis high-order Bessel (vortex) beam (HOBVB). According to the orthogonality of the associated Legendre function and exponential function, a concise expression of the expansion coefficients of the off-axis HOBVB in terms of the spherical vector wave functions (SVWFs) is derived that can effectively reconstruct the HOBVB with all conical angles. The differences of scattering characteristics of a uniaxial anisotropic sphere illuminated by an on-axis and off-axis HOBVB and a plane wave are exhibited.

Valvular heart disease and heart-related disease: a bibliometric and visual analysis from 2000 to 2023.

Background: Previous studies have shown that valvular heart disease (VHD) is closely related to the development of heart-related disease (HRD). However, the current research for the relationship between VHD and HRD is complex and poorly targeted. Meanwhile, these studies lack the support of bibliometric analysis results.

Electrodepositing Ag on Anodized Stainless Steel for Enhanced Antibacterial Properties and Corrosion Resistance.

Antibacterial stainless steels have been widely used in biomedicine, food, and water treatment. However, the current antibacterial stainless steels face challenges in balancing corrosion resistance and antibacterial effectiveness, limiting their application range and lifespan. In this study, an oxide layer sealed with antibacterial Ag particles was constructed on the surface of 304 stainless steel through anodizing and electrodeposition, and the process parameters were optimized for achieving long-term antibacterial properties.

Investigation of microbial induced calcium carbonate and struvite co-precipitation on cementitious material surfaces.

Microbial-induced carbonate precipitation (MICP) has garnered increasing attention in the realm of building materials. Among them, urease microorganisms have been extensively investigated due to their favorable attributes, including facile reaction control, heightened mineralization efficiency, and straightforward microorganism cultivation. Nevertheless, the presence of ammonia byproducts throughout the reaction process significantly restricted its extensive utilization.

Clinical novel exploration of intractable fever in stroke rehabilitation: a single-center cross-sectional retrospective study.

Fever has long been recognized as one of the earliest clinical indicators of illness and remains a leading reason for seeking medical care worldwide. It is typically classified based on its duration and underlying etiology. In clinical settings, intractable fever is as common as acute fever, particularly in patients with brain injuries.

Analysis of factors influencing the awareness of inpatients regarding hospital clinical pharmacy services and willingness to pay: a multicenter survey in Hebei Province, China.

Introduction: Pharmacists are increasingly adopting patient-centered roles, improving healthcare outcomes by reducing medication errors and costs. In China, recent healthcare reforms recognize and compensate for pharmacy services. However, patient awareness of these services and their willingness to pay (WTP) remain underexplored.

Molecular characterization of EBV-associated primary pulmonary lymphoepithelial carcinoma by multiomics analysis.

Background: Primary pulmonary lymphoepithelial carcinoma (pLEC) is a subtype of non-small cell lung cancer (NSCLC) characterized by Epstein-Barr virus (EBV) infection. However, the molecular pathogenesis of pLEC remains poorly understood.

Methods: In this study, we explored pLEC using whole-exome sequencing (WES) and RNA-whole-transcriptome sequencing (RNA-seq) technologies.

A new phase of China-ASEAN health cooperation: the China-ASEAN Beijing Declaration on Cooperation in Innovation of Health Products and Technologies.

Utilizing innovative methods to advance the research and development (R&D) of health products and enhance their accessibility has become crucial to achieving universal health coverage, addressing public health emergencies, and promoting population health and wellbeing. However, structural contradictions do exist in the supply and demand of health products in the Association of Southeast Asian Nations (ASEAN). With the joint support of the Ministry of Science and Technology of China, the Ministry of Education, and the China-ASEAN Center, Peking University established the China-ASEAN Science and Technology Cooperation Center for Public Health in April 2023.

Dietary Vitamin Intake Among Chinese Adults - 10 PLADs, China, 2022-2023.

What Is Already Known About This Topic?: Previous surveillance data from 2015-2017 showed that Chinese adults aged 18 to 59 years had mean daily vitamin intakes of 406.8 μg retinol equivalent (RE) for vitamin A, 36.7 mg for vitamin E, 0.

Macroelements Intake in Chinese Adults - 10 PLADs, China, 2022-2023.

What Is Already Known About This Topic?: The Chinese Nutrition and Health Surveillance in 2015-2017 reported that among adults aged 18-59 years, the average daily intake was 328.3 mg of calcium, 251.8 mg of magnesium, 5,681.

Synergistic Synbiotic-Containing and Fructo-Oligosaccharide Alleviate the Allergenicity of Mice Induced by Soy Protein.

Prebiotics and probiotics have key roles in the intervention and treatment of food allergies. This study assesses the effect of synergistic fructo-oligosaccharide (Lp-FOS) intervention using an allergic mouse model induced by soy protein. The results showed that Lp synergistic FOS significantly decreased clinical allergy scores, inhibited specific antibodies (IgE, IgG, and IgG1), IL-4, IL-6, and IL-17A levels, and increased IFN-γ and IL-10 levels.

LAPTM5 Confers the Resistance to Venetoclax via Promoting the Autophagosome-Lysosome Fusion in Multiple Myeloma.

Multiple myeloma (MM) is a haematological lymphoid malignancy marked by significant morbidity due to severe complications. Despite advances in targeted therapies, including proteasome inhibitors and the BCL-2 inhibitor venetoclax, drug resistance frequently occurs, with the underlying mechanisms poorly understood. This study investigates the role of lysosome-associated protein transmembrane 5 (LAPTM5) in conferring resistance to venetoclax in relapsed MM.

The time-stamped effects of screen exposure on food intake in adults: A meta-analysis of experimental studies.

Objective: The purpose of this study was to examine time-stamped impacts of screen exposure on food intake among healthy adults.

Methods: Four electronic databases were searched up to August 31, 2024, including ProQuest, PubMed, Web of Science and Embase. A meta-analysis of inverse variance was used to calculate the standardized mean difference (SMD) in food intake between watching and not watching screen groups, and groups with different screen contents (e.