Effects of intermittent theta burst stimulation add-on to dialectical behavioral therapy in borderline personality disorder: results of a randomized, sham-controlled pilot trial.

Dialectical behavioral therapy (DBT) and repetitive transcranial magnetic stimulation (rTMS) are both effective in borderline personality disorder (BPD). We hypothesized that intermittent theta burst stimulation (iTBS), a modified rTMS protocol that provides unilateral stimulation to the left dorsolateral prefrontal cortex, would enhance the effects of DBT and reduce BPD-specific symptoms more than sham stimulation. We performed a single-blind, randomized, sham-controlled pilot study to evaluate iTBS as an add-on to 8-week DBT for BPD in routine inpatient treatment.

Side-effect expectations are associated with disability, physical fitness, and somatic symptoms 3 months after post-COVID neurological inpatient rehabilitation.

Introduction: The COVID-19 pandemic, caused by SARS-CoV-2, has led to long-term health issues known as post-COVID-19 condition, including fatigue and cognitive disruptions. Despite its recognition as a public health concern, the efficacy of therapeutic interventions, especially in neurological rehabilitation, remains unclear. This study examines how treatment expectations are associated with psychological and physical outcomes in post-COVID-19 condition neurological rehabilitation.

Comparison of 8-vs-12 weeks, adapted dialectical behavioral therapy (DBT) for borderline personality disorder in routine psychiatric inpatient treatment-A naturalistic study.

Dialectical behavior therapy (DBT) is widely acknowledged as an effective treatment for individuals with borderline personality disorder (BPD). However, the optimal treatment duration within DBT remains a topic of investigation. This retrospective, naturalistic non-randomized study aimed to compare the efficacy of 8 week and 12 week DBT interventions with equivalent content, focusing on the change of BPD-specific symptomatology as the primary outcome and depressive symptoms as the secondary outcome.

Theta burst stimulation add on to dialectical behavioral therapy in borderline-personality-disorder: methods and design of a randomized, single-blind, placebo-controlled pilot trial.

Specialized psychotherapeutic treatments like dialectical behavioral therapy (DBT) are recommended as first treatment for borderline personality disorder (BPD). In recent years, studies have emerged that focus on repetitive transcranial magnetic stimulation (rTMS) in BPD. Both have independently demonstrated efficacy in the treatment of BPD.

Effects of progesterone on gender affirmation outcomes as part of feminizing hormone therapy.

Background: The use of progesterone as a component of feminizing gender-affirming hormone therapy (GAHT) is controversial; however, use in transgender women continues owing to anecdotal reports of benefit.

Objectives: This study aimed to provide quantifiable outcomes data regarding the use of progesterone in transgender women by comparing groups from this population who use feminizing GAHT with and without progesterone.

Methods: This retrospective cohort study captured data from transgender female patients seen at the Summa PRIDE Clinic between September 2019 and December 2021.

Growing up amid conflict: Implications of the Developmental Peacebuilding Model.

Worldwide, 420 million children are affected by conflict and over half of all children experience violence every year. Thus, youth are unarguably affected by war and settings of persisting societal violence. Despite often being conceptualized as either powerless victims or violent perpetrators, recent advances in research and international policy recognize young people as key change agents in transforming adverse settings into positive environments.

Velocity discontinuity propagation model validation using an approximate point source in motion.

The classic geometric acoustic solution for propagation through a mean flow velocity discontinuity is evaluated experimentally using an approximate point source in motion. The geometric approximation of the pressure field in the frequency and time domains is, first, revisited for arbitrary subsonic flow and source motion along the flow axis. The derivation, computed via the method of stationary phase, shows the expected Doppler behavior of the radiated acoustic field due to the source motion acting in conjunction with the convective amplification effect for a stationary source in flow.

How liquid-liquid phase separation induces active spreading.

The interplay between phase separation and wetting of multicomponent mixtures is ubiquitous in nature and technology and recently gained significant attention across scientific disciplines, due to the discovery of biomolecular condensates. It is well understood that sessile droplets, undergoing phase separation in a static wetting configuration, exhibit microdroplet nucleation at their contact lines, forming an oil ring during later stages. However, very little is known about the dynamic counterpart, when phase separation occurs in a nonequilibrium wetting configuration, i.

Leaf layer-based transcriptome profiling for discovery of epidermal-selective promoters in Medicago truncatula.

Transcriptomics of manually dissected leaf layers from Medicago truncatula identifies genes with preferential expression in upper and/or lower epidermis. The promoters of these genes confer epidermal-specific expression of transgenes. Improving the quality and quantity of proanthocyanidins (PAs) in forage legumes has potential to improve the nitrogen nutrition of ruminant animals and protect them from the risk of pasture bloat, as well as parasites.

Towards a Stochastic Model to Simulate Grapevine Architecture: A Case Study on Digitized Riesling Vines Considering Effects of Elevated CO.

Modeling plant growth, in particular with functional-structural plant models, can provide tools to study impacts of changing environments in silico. Simulation studies can be used as pilot studies for reducing the on-field experimental effort when predictive capabilities are given. Robust model calibration leads to less fragile predictions, while introducing uncertainties in predictions allows accounting for natural variability, resulting in stochastic plant growth models.

Enabling high-power, broadband THz generation with 800-nm pump wavelength.

The organic terahertz (THz) generation crystal BNA has recently gained traction as a source for producing broadband THz pulses. When pumped with 100 fs pulses, the thin BNA crystals can produce relatively high electric fields with frequency components out to 5 THz. However, the THz output with 800-nm pump wavelength is limited by the damage threshold of the material, particularly when using a 1 kHz or higher repetition rate laser.

Lattice Boltzmann and Jones matrix calculations for the determination of the director field structure in self-propelling nematic droplets.

Nematic droplets immersed in aqueous surfactant solutions can show a self-propelled motion induced by a Marangoni flow in the droplet surface. In addition to the self-propulsion, the Marangoni flow induces within the droplet a convective flow which considerably influences the nematic director field of the droplet. We report numerical simulations aiming at the determination of the director field in the self-propelling droplet.

Missing Links in Predicting Berry Sunburn in Future Vineyards.

Sunburn in grapevine berries is known as a recurring disorder causing severe yield losses and a decline in berry quality. The transition from healthy to sunburnt along a temporal trajectory is not fully understood. It is driven by light-boosted local heat impact and modulated by, e.

Self-shaping liquid crystal droplets by balancing bulk elasticity and interfacial tension.

The shape diversity and controlled reconfigurability of closed surfaces and filamentous structures, universally found in cellular colonies and living tissues, are challenging to reproduce. Here, we demonstrate a method for the self-shaping of liquid crystal (LC) droplets into anisotropic and three-dimensional superstructures, such as LC fibers, LC helices, and differently shaped LC vesicles. The method is based on two surfactants: one dissolved in the LC dispersed phase and the other in the aqueous continuous phase.

Investigating real-life emotions in romantic couples: a mobile EEG study.

The neural basis of emotional processing has been largely investigated in constrained spatial environments such as stationary EEGs or fMRI scanners using highly artificial stimuli like standardized pictures depicting emotional scenes. Typically, such standardized experiments have low ecological validity and it remains unclear whether their results reflect neuronal processing in real-life affective situations at all. Critically, emotional situations do not only encompass the perception of emotions, but also behavioral components associated with them.

Predicting breakthrough of vanadium in fixed-bed absorbent columns with complex groundwater chemistries: A multi-component granular ferric hydroxide-vanadate-arsenate-phosphate-silicic acid system.

Granular ferric hydroxide (GFH) is often used for fixed bed adsorbent (FBA) columns in groundwater purification units around the world to remove arsenate contaminations. Groundwater can contain also other toxic (e.g.

Topological Stabilization and Dynamics of Self-Propelling Nematic Shells.

Liquid shells (e.g., double emulsions, vesicles, etc.

Terahertz generation and optical characteristics of P-BI.

We present the structural and THz generation characteristics of the molecular salt crystal (E)-2-(4-(dimethylamino)styryl)-1,1,3-trimethyl-1H-benzo[e]indol-3-ium iodide (P-BI) using optical rectification with IR pump wavelengths. P-BI shows a peak-to-peak field ∼6 times greater than inorganic crystal GaP, and a broader THz spectrum. Data were obtained from 0-6 THz showing a significant dip in generation at 1.

Surface glycan-binding proteins are essential for cereal beta-glucan utilization by the human gut symbiont Bacteroides ovatus.

The human gut microbiota, which underpins nutrition and systemic health, is compositionally sensitive to the availability of complex carbohydrates in the diet. The Bacteroidetes comprise a dominant phylum in the human gut microbiota whose members thrive on dietary and endogenous glycans by employing a diversity of highly specific, multi-gene polysaccharide utilization loci (PUL), which encode a variety of carbohydrases, transporters, and sensor/regulators. PULs invariably also encode surface glycan-binding proteins (SGBPs) that play a central role in saccharide capture at the outer membrane.

Structural basis of Toxoplasma gondii perforin-like protein 1 membrane interaction and activity during egress.

Intracellular pathogens must egress from the host cell to continue their infectious cycle. Apicomplexans are a phylum of intracellular protozoans that have evolved members of the membrane attack complex and perforin (MACPF) family of pore forming proteins to disrupt cellular membranes for traversing cells during tissue migration or egress from a replicative vacuole following intracellular reproduction. Previous work showed that the apicomplexan Toxoplasma gondii secretes a perforin-like protein (TgPLP1) that contains a C-terminal Domain (CTD) which is necessary for efficient parasite egress.

Author Correction: BCAT1 restricts αKG levels in AML stem cells leading to IDH-like DNA hypermethylation.

In Extended Data Fig. 1a of this Letter, the flow cytometry plot depicting the surface phenotype of AML sample DD08 was a duplicate of the plot for AML sample DD06. Supplementary Data 4 has been added to the Supplementary Information of the original Letter to clarify the proteome data acquisition and presentation.

Author Correction: A Myc enhancer cluster regulates normal and leukaemic haematopoietic stem cell hierarchies.

In the originally published version of this Letter, ref. 43 was erroneously provided twice. In the 'Estimation of relative cell-type-specific composition of AML samples' section in the Methods, the citation to ref.

Performance of human observers and an automatic 3-dimensional computer-vision-based locomotion scoring method to detect lameness and hoof lesions in dairy cows.

The objective of this study was to determine if a 3-dimensional computer vision automatic locomotion scoring (3D-ALS) method was able to outperform human observers for classifying cows as lame or nonlame and for detecting cows affected and nonaffected by specific type(s) of hoof lesion. Data collection was carried out in 2 experimental sessions (5 mo apart). In every session all cows were assessed for (1) locomotion by 2 observers (Obs1 and Obs2) and by a 3D-ALS; and (2) identification of different types of hoof lesions during hoof trimming (i.

Jet Noise Shielding Provided by a Hybrid Wing Body Aircraft.

One approach toward achieving NASA's aggressive N+2 noise goal of 42 EPNdB cumulative margin below Stage 4 is through the use of novel vehicle configurations like the Hybrid Wing Body (HWB). Jet noise measurements from an HWB acoustic test in the NASA Langley 14- by 22-Foot Subsonic Tunnel are described. Two dual-stream, heated Compact Jet Engine Simulator (CJES) units are mounted underneath the inverted HWB model on a traversable support to permit measurement of varying levels of shielding provided by the fuselage.