Improved DNA equilibrium binding affinity determinations of platinum(II) complexes using synchrotron radiation circular dichroism.

The binding affinity of a series of square planar platinum(II) compounds of the type [Pt(A(L))(I(L))](2+), where A(L) is 1,2-diaminoethane and I(L) are 1,10-phenanthroline (phen), 4-methyl-1,10-phenanthroline (4Mephen), 5-methyl-1,10-phenanthroline (5Mephen), 4,7-dimethyl-1,10-phenanthroline (47Me2phen), 5,6-dimethyl-1,10-phenanthroline (56Me2phen) or 3,4,7,8-tetramethyl-1,10-phenanthroline (3478Me4phen) has been reinvestigated using Synchrotron Radiation Circular Dichroism (SRCD) spectroscopy. The additional peaks exhibited considerably greater intensity than those observed between 200 and 400 nm affording additional binding affinity determinations. In addition, the authors have reviewed the various mathematical approaches used to estimate equilibrium binding constants and thereby demonstrate that their mathematical approach, implemented with Wolfram Mathematica, has merit over other methods.

A magnetic gradient induced force in NMR restricted diffusion experiments.

We predict that the phase cancellation of a precessing magnetisation field carried by a diffusing species in a bounded geometry under certain nuclear magnetic resonance pulsed magnetic field gradient sequences results in a small force over typically micrometre length scales. Our calculations reveal that the total magnetisation energy in a pore under the influence of a pulsed gradient will be distance-dependent thus resulting in a force acting on the boundary. It is shown that this effect of the magnetisation of diffusing particles will appear as either an attractive or repulsive force depending on the geometry of the pore and magnetic properties of the material.

Numerical analysis of NMR diffusion measurements in the short gradient pulse limit.

Pulsed gradient spin-echo (PGSE) NMR diffusion measurements provide a powerful technique for probing porous media. The derivation of analytical mathematical models for analysing such experiments is only straightforward for ideal restricting geometries and rapidly becomes intractable as the geometrical complexity increases. Consequently, in general, numerical methods must be employed.

Restricted diffusion in annular geometrical pores.

Nuclear magnetic resonance (NMR) diffusion (including diffusion MRI) experiments are only as powerful as the models used to analyse the NMR diffusion data. A major problem, especially with measurements on biological systems, is that the existing models are only very poor approximations of cellular shape. Here, diffusion propagators and pulsed gradient spin-echo attenuation equations are derived in the short gradient pulse limit for diffusion within the annular region of a concentric cylinder of finite length and, similarly, within the annular region of a concentric sphere.

Modeling diffusion in restricted systems using the heat kernel expansion.

The averaged return-to-origin probability of finding a diffusing particle within a volume or in the neighborhood of the surface of a bounded region can be separated into a volume and a surface integral of the corresponding probability densities. However with the usual treatments (e.g.