Early detection of recurrence after curative resection for colorectal cancer - obstacles when using soluble biomarkers?

Objective: Results from monitoring studies using biomarkers in blood samples aiming at early detection of recurrent colorectal cancer (CRC) are presently evaluated. However, some serological biomarker levels are influenced by the surgical trauma, which may complicate translation of the levels in relation to recurrence. The primary purpose of the present study was to evaluate the frequency of postoperative surgical interventions during a follow-up period of patients who have undergone surgery for primary CRC.

[Perineal wound complications following preoperative radiotherapy for rectal cancer].

Introduction: Every year, approximately 1200 new cases of rectal cancer are registered in Denmark. Preoperative radiation therapy alone or in combination with chemotherapy (chemo-radiation) is a gold standard in the treatment of patients with T3 and T4 tumours. Although it carries a good response rate, preoperative radiation is associated with significant morbidity including wound infection and delayed healing.