Publications by authors named "Bahast Biuk"
Glutamate, GABA and NAA in treatment-resistant schizophrenia: A systematic review of the effect of clozapine and group differences between clozapine-responders and non-responders.
Milo Wolfgang Pilgaard Kristensen Bahast Biuk Jimmi Nielsen Kirsten Borup Bojesen Mette Ødegaard Nielsen
Behav Brain Res
February 2025
Article Synopsis
- Treatment-resistance in schizophrenia poses significant challenges, particularly for patients who do not respond to clozapine, with emerging research suggesting potential glutamatergic and GABAergic imbalances in these individuals.
- A systematic review analyzed nine studies using proton magnetic resonance spectroscopy (H-MRS) to assess the impact of clozapine on brain metabolite levels in treatment-resistant (TRS) and ultra-treatment-resistant schizophrenia (UTRS) patients, following PRISMA guidelines.
- The findings suggest clozapine may lower glutamate levels in specific brain areas while possibly increasing GABA and N-acetylaspartate (NAA), highlighting the need for more comprehensive studies to better understand these effects and their implications for