Publications by authors named "Bahareh Nemati Moud"
CARD-BCL10-MALT1 (CBM) signalosomes connect distal signaling of innate and adaptive immune receptors to proximal signaling pathways and immune activation. Four CARD scaffold proteins (CARD9, 10, 11, 14) can form seeds that nucleate the assembly of BCL10-MALT1 filaments in a cell- and stimulus-specific manner. MALT1 (also known as PCASP1) serves a dual function within the assembled CBM complexes.
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- Recent studies have linked a genetic risk for type 2 diabetes with a lower likelihood of accumulating body fat, paralleling traits seen in metabolically obese normal weight (MONW) individuals.
- Researchers identified a specific genetic variant (rs6712203) in the COBLL1 gene that influences gene expression and affects how fat cells grow and store lipids, leading to difficulties in developing proper adipose tissue.
- Using mouse models, they demonstrated that altering the COBLL1 gene mirrors MONW traits, including reduced body fat and impaired glucose regulation, highlighting a potential target for future diabetes treatments and understanding of genetic influences on metabolism.
Introduction: Brown adipose tissue (BAT) serves to produce heat by nonshivering thermogenesis. Activation of BAT increases energy expenditure and is seen as a putative strategy to treat obesity. There are conflicting data on the capacity for cold-induced thermogenesis in individuals with higher BMI.
View Article and Find Full Text PDFPositive selection in Europeans at the 2q21.3 locus harboring the lactase gene has been attributed to selection for the ability of adults to digest milk to survive famine in ancient times. However, the 2q21.
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