Comparison of the efficacy of 5% topical spironolactone gel and placebo in the treatment of mild and moderate acne vulgaris: a randomized controlled trial.

Background: Topical spironolactone may be effective for the treatment of acne patients with increased sebum secretion.

Objective: To evaluate the efficacy of 5% spironolactone gel in the treatment of mild to moderate acne vulgaris.

Methods: This study was a double-blind clinical trial, performed randomly in two demographically equivalent groups.