Cognitive activity analysis of Parkinson's patients using artificial intelligence techniques.

Purpose: The development of modern Artificial Intelligence (AI) based models for the early diagnosis of Parkinson's disease (PD) has been gaining deep attention by researchers recently. In particular, the use of different types of datasets (voice, hand movements, gait, etc.) increases the variety of up-to-date models.

Real-World Experience of Fluocinolone Acetonide 0.19 mg in the Management of Non-Infectious Uveitis.

Purpose: This study aims to evaluate the real-world efficacy and safety profile of fluocinolone acetonide (FAc) implants for the treatment of non-infectious uveitis (NIU).

Methods: A retrospective, observational study was conducted at Moorfields Eye Hospital, London, involving patients who received FAc 0.19 mg implants (Iluvien®) for NIU.

Detection of Parkinson's disease with keystroke data.

Parkinson's disease (PD) is one of the most widespread neurological disorders associated with nerve damage without definitive treatment. Impairments, such as trembling and slowing down in hand movements are among the first symptoms. For this purpose, in this study, machine learning (ML)-based models were developed by using keyboard keystroke dynamics.

Outcomes of anti-VEGF treatment for macular edema secondary to central retinal vein occlusion in patients with poor baseline visual acuity.

Objective: To report the visual outcomes of intravitreal anti-vascular endothelial growth factor (anti-VEGF) treatment for macular edema secondary to central retinal vein occlusion (CRVO) in patients with baseline visual acuity of ≤23 ETDRS letters vision.

Design: Retrospective observational cohort study.

Methods: This is a single-institution study.

Some Thiazole Derivatives Combined with Different Heterocycles: Cytotoxicity Evaluation and Apoptosis Inducing Studies.

Background: Thiazole ring is an outstanding structure found in many biologically active compounds and clinically available drugs. Because of synthesis simplicity of its derivatives and having a wide range of biological aspects along with high effectiveness, new thiazole derivatives have been studied by medicinal chemists since many years.

Objective: Some thiazole compounds combined with different heterocyclic rings were acquired in this study.

Biological Activity Evaluation of Novel 1,2,4-Triazine Derivatives Containing Thiazole/Benzothiazole Rings.

Background: Triazine ring is a prominent structural motif found in some azanucleosides whose efficiency improved many times in the research area of antitumor agents.

Objective: In this study, we have designed and synthesized novel 2-[(5,6-diphenyl-1,2,4-triazin-3-yl)thio]-N-(6- substituted benzo/(thiazol)-2-yl)acetamide (2a-d, 3a-f) derivatives using 1,2,4-triazine core along with two important heterocyles, thiazole and benzothiazole rings.

Method: The acquired ten final compounds were screened to investigate their antitumor activity against lung adenocarcinoma cell line, A549 and mouse fibroblast cell line, NIH/3T3.