Maps and sensorimotor transformations for eye-head gaze shifts: Role of the midbrain superior colliculus.

Single-unit recordings in head-restrained monkeys indicated that the population of saccade-related cells in the midbrain Superior Colliculus (SC) encodes the kinematics of desired straight saccade trajectories by the cumulative number of spikes. In addition, the nonlinear main sequence of saccades (their amplitude-peak velocity saturation) emerges from a spatial gradient of peak-firing rates of collicular neurons, rather than from neural saturation at brainstem burst generators. We here extend this idea to eye-head gaze shifts and illustrate how the cumulative spike-count in head-unrestrained monkeys relates to the desired gaze trajectory and its kinematics.

Electrical stimulation in a spiking neural network model of monkey superior colliculus.

The superior colliculus (SC) generates saccades by recruiting a population of cells in its topographically organized motor map. Supra-threshold electrical stimulation in the SC produces a normometric saccade with little effect of the stimulation parameters. Moreover, the kinematics of electrically evoked saccades strongly resemble natural, visual-evoked saccades.

Microstimulation in a spiking neural network model of the midbrain superior colliculus.

The midbrain superior colliculus (SC) generates a rapid saccadic eye movement to a sensory stimulus by recruiting a population of cells in its topographically organized motor map. Supra-threshold electrical microstimulation in the SC reveals that the site of stimulation produces a normometric saccade vector with little effect of the stimulation parameters. Moreover, electrically evoked saccades (E-saccades) have kinematic properties that strongly resemble natural, visual-evoked saccades (V-saccades).

Dynamic parallelism for synaptic updating in GPU-accelerated spiking neural network simulations.

Graphical processing units (GPUs) can significantly accelerate spiking neural network (SNN) simulations by exploiting parallelism for independent computations. Both the changes in membrane potential at each time-step, and checking for spiking threshold crossings for each neuron, can be calculated independently. However, because synaptic transmission requires communication between many different neurons, efficient parallel processing may be hindered, either by data transfers between GPU and CPU at each time-step or, alternatively, by running many parallel computations for neurons that do not elicit any spikes.

Modeling auditory-visual evoked eye-head gaze shifts in dynamic multisteps.

In dynamic visual or auditory gaze double-steps, a brief target flash or sound burst is presented in midflight of an ongoing eye-head gaze shift. Behavioral experiments in humans and monkeys have indicated that the subsequent eye and head movements to the target are goal-directed, regardless of stimulus timing, first gaze shift characteristics, and initial conditions. This remarkable behavior requires that the gaze-control system 1) has continuous access to accurate signals about eye-in-head position and ongoing eye-head movements, 2) that it accounts for different internal signal delays, and 3) that it is able to update the retinal ( T) and head-centric ( T) target coordinates into appropriate eye-centered and head-centered motor commands on millisecond time scales.

Double Stimulation in a Spiking Neural Network Model of the Midbrain Superior Colliculus.

The midbrain superior colliculus (SC) is a crucial sensorimotor interface in the generation of rapid saccadic gaze shifts. For every saccade it recruits a large population of cells in its vectorial motor map. Supra-threshold electrical microstimulation in the SC reveals that the stimulated site produces the saccade vector specified by the motor map.

A spiking neural network model of the midbrain superior colliculus that generates saccadic motor commands.

Single-unit recordings suggest that the midbrain superior colliculus (SC) acts as an optimal controller for saccadic gaze shifts. The SC is proposed to be the site within the visuomotor system where the nonlinear spatial-to-temporal transformation is carried out: the population encodes the intended saccade vector by its location in the motor map (spatial), and its trajectory and velocity by the distribution of firing rates (temporal). The neurons' burst profiles vary systematically with their anatomical positions and intended saccade vectors, to account for the nonlinear main-sequence kinematics of saccades.