Publications by authors named "Bahaa N Francis"
Purpose: There is variation in organization of geriatric rehabilitation across Europe. The purpose of this study was to describe the selection criteria for referral to geriatric rehabilitation, care provided, and recovery trajectories of post-COVID-19 patients referred to geriatric rehabilitation in Europe.
Methods: This observational cohort study included 723 patients in 59 care facilities for geriatric rehabilitation across 10 countries.
Article Synopsis
- Older individuals recovering from COVID-19 can significantly improve their daily functioning and quality of life through geriatric rehabilitation (GR), as shown in a study across 59 facilities in Europe.
- The study tracked 723 post-COVID-19 patients, most of whom were frail at admission, and found that they experienced steady improvements in functioning and quality of life over time, regardless of their frailty level.
- Importantly, while frailer patients had lower quality of life at admission, they showed a quicker recovery, suggesting that frailty should not be a barrier to receiving geriatric rehabilitation.
Purpose: Pulmonary Hypertension (PH) is complex disease which is associated with endothelial and cardiac dysfunction. Tetrahydrobiopterin (BH ) regulates endothelial nitric oxide synthase (eNOS) to produce nitric oxide rather than superoxide which maintains normal endothelial and cardiac function. This study explores the therapeutic potential of BH in experimental PH.
View Article and Find Full Text PDFEndothelial nitric oxide synthase (eNOS) plays a major role in maintaining pulmonary vascular homeostasis. Tetrahydrobiopterin (BH4), an essential cofactor that stabilizes the dimerization of eNOS and balances nitric oxide (NO) and superoxide production, may have therapeutic potential in pulmonary hypertension. In the isolated perfused lung, we demonstrated a direct effect of exogenous administration of BH4 on pulmonary NO production, leading to acute vasorelaxation during the plateau phase of hypoxia-induced pulmonary vasoconstriction.
View Article and Find Full Text PDFEndothelin-1 (ET-1) exerts its biological actions through two receptor subtypes: endothelin-A (ETA) receptor and endothelin-B (ETB) receptor. We demonstrated previously that ET-1 induces systemic and renal cortical vasoconstriction via ETA whereas ETB mediates medullary vasodilation. Congestive heart failure (CHF) is characterized by increased vascular resistance and impaired renal hemodynamic and excretory function.
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