Immunohistochemical study of MUC1, MUC2 and MUC5AC in colorectal carcinoma and review of literature.

Background: A hallmark of colorectal carcinomas is their ability to secrete mucus. Aberrant expression of mucins and alterations in their glycosylation are associated with the development and progression of malignant diseases. Therefore, mucins can be used as markers of malignancy.