Publications by authors named "Bagaturiya G"
Article Synopsis
- Recent studies have established a clear link between the structural design of drug compounds and their biological effectiveness, highlighting the importance of stereoisomers in both therapeutic outcomes and potential side effects.
- The use of computational methods, particularly Quantitative Structure-Activity Relationships (QSAR) alongside molecular modeling, has become essential in modern drug discovery, allowing for computer-based drug searches before moving to lab experiments.
- With over 101 million known organic compounds and more than 25,000 recognized biological activities, in silico methods are increasingly vital for efficiently screening and identifying promising drug candidates.
According to the experimental data a triterpene alcohol betulin have anti-inflammatory, wound- and burn-healing activity. Previous data reports, that betulin was used in not less than 5% concentrations. That is why studying less concentrations is of major interest.
View Article and Find Full Text PDFDepression is one the most common form of mental diseases. Due to epidemiological studies, it is common in different age groups including young people. Depression pathogenesis from the point of system perspective view consists of morphofunctional and pathopsychological components.
View Article and Find Full Text PDFArticle Synopsis
- The article discusses a multicenter study in Russia on infective endocarditis, focusing on the causes, antibiotic effectiveness, and drug usage patterns.
- The study analyzed 406 cases, finding that 35.5% had identifiable pathogens, primarily gram-positive cocci, with Staphylococcus aureus being the most common at 46.5%.
- The research highlighted the frequent use of aminoglycosides and third-generation cephalosporins in initial treatment, while adjustments in therapy often involved glycopeptides and fluoroquinolones.
Article Synopsis
- Thyroid hormones influence immune cell responses, impacting inflammation processes in the body.
- The study aimed to investigate how hyperthyroidism and hypothyroidism induce inflammation in the colon, using an experiment on 60 male mice.
- Results showed that hyperthyroid mice had colonic mucosal hypertrophy and increased immune cell activity, while hypothyroid mice exhibited colonic mucosal atrophy with minimal immune response, suggesting thyroid status plays a role in regulating inflammation.
Corticoliberin (CRF) isn't only regulates hypothalamic-pituitary-adrenal axis activity, but also functions as a neurotransmitter in extrahypothalamic brain regions like amygdala, implicated in the emotional responses to stress. The CRF system provides an input to orexin neurons and can modulate the activity of orexinergic neurons in stress response. Some data showed the role of orexin-A in extinction of aversive memory.
View Article and Find Full Text PDFThe state of physiological functions of the whole organism, its vital activity and adaptation to various changes in the surrounding and internal environment is controlled by neurohumoral mechanisms. The main place in the implementation of those mechanisms belongs to hormones. A clinically relevant problem is currently the relationship between activity of thyroid gland and prolactin.
View Article and Find Full Text PDF