The Role of Tumor-Associated Neutrophils in Early Luminal HER2-Negative Breast Cancer Progression.

Objectives: To study the predictive role of tumor-associated neutrophils in early luminal HER2-negative breast cancer.

Materials And Methods: This is a retrospective study conducted on 60 women cases aged from 31 to 79 years underwent surgery for luminal HER2-negative ductal breast cancer in tertiary care cancer centre. We first estimated basic morphological signs: tumor size, tumor grade (by Nottingham Histologic Score), tumor infiltrating lymphocytes (TILs), Lymphovascular invasion, hormonal receptors status, proliferative index, and regional lymph nodes metastasis.

Integral scales in assessing the risk of postoperative morbidity and mortality.

Annual number of surgeries exceeds 10 million In Russia, and this number is increasing every year. Searching for a scale or index determining the risk of postoperative complications and mortality is an important issue all over the world. The authors analyzed all available risk assessment scales for postoperative morbidity and mortality.

[Optimization of surgical care for the hemorrhagic colorectal cancer].

Aim: To optimize surgical care for the hemorrhagic colorectal cancer.

Material And Methods: 77 patients diagnosed with hemorrhagic colorectal cancer were reviewed: 9 patients of them were efficaciously treated with conservative therapy (I group); 47 - underwent successful endoscopic coagulation (I); 4 - arterial embolization (I), 2 - ligation of internal iliac arteries (I), 15 - acute resection (II group). 20 of 62 patients I group underwent plan surgery and radiation or chemotherapy during 7-10 days after hemostasis and normalization hemoglobin.

[Standardization of surgical care for malignant colonic obstruction].

Aim: To standardize surgical care for malignant colonic obstruction.

Material And Methods: There were 572 patients with malignant colonic obstruction: 247 of them were hospitalized in 2011-2013 (I group); 325 - in 2014-2017 (group II). Forty-six patients underwent medication; 302 - acute resection; 141 - stoma construction; 83 - stent deployment.

[The optimal terms of the second stage of treatment of patients with malignant colonic obstruction].

Aim: To determine the optimal terms of the second stage of treatment of patients with malignant colonic obstruction.

Material And Methods: There were 110 patients with colorectal cancer stage TNM (groups I-III, n=69) and TNM (group IV, n=41). Everybody has been previously treated for colonic obstruction 0,5-6 months ago: stoma in 62 cases, stenting - in 48 cases.

[Urgent surgical care for patients with colon cancer complicated by hemorrhage].

Aim: To evaluate an effectiveness of various hemostatic methods in patients with colon and rectal cancer.

Material And Methods: 77 urgent patients with colon and rectal cancer complicated by bleeding were enrolled. Medication was effective in 11 patients (group 1), endoscopic hemostasis in 47 patients (group 2), vascular embolization in 2 cases (group 3), internal iliac arteries ligation in 2 patients (group 4), 15 patients underwent emergency resection (group 5).

[Managerial and methodological aspects of emergency surgery for malignant colonic obstruction].

Aim: To determine the most feasible treatment strategy for malignant colonic obstruction.

Material And Methods: There were 427 patients with malignant colonic obstruction who were hospitalized for emergency indications. 30 of them were treated with medical therapy; 286 - underwent acute resection; 43 - stoma construction; 68 - stents deployment.

[Urgent surgical care for patients with colon cancer complicated by hemorrhage].

Aim: Comparative evaluation of the effectiveness of various hemostatic methods in patients with colon and rectal cancer complicated by bleeding.

Material And Methods: We examined 77 hospitalized patients with colon and rectal cancer complicated by bleeding. Conservative therapy was effective in 11 patients (group I), endoscopic hemostasis in 49 cases (group II), 17 patients underwent emergency surgery (bowel resection/ internal iliac arteries ligation) (group III).

[Metal self-expanding stents for malignant obstruction of stomach outlet and duodenum].

Aim: To compare different types of self-expanding stents (partially coated or uncovered) for malignant pyloroduodenal obstruction (MPDO).

Material And Methods: 89 MPDO patients underwent stenting at the Botkin City Hospital (Moscow) for the period 2008-2016. The causes of malignant obstruction were: stomach cancer - 53 (59.