A comparison of androgens for anemia in patients on hemodialysis.

To compare the erythropoietic effects of nandrolone decanoate, testosterone enanthate, oxymetholone, and fluoxymesterone, we performed a randomized clinical trial in patients with anemia who were receiving maintenance hemodialysis (the women were not given testosterone enanthate). After a control period of at least two months, patients received one of the drugs for six months and then returned to control status; a second and third drug were administered in a similar fashion. Seventy-seven patients completed the first drug period, 56 the second, and 35 the third.

Experience with arterial substitutes in the construction of vascular access for hemodialysis.

Thirty autogenous saphenous vein grafts, 91 modified bovine heterografts and 96 PTFE grafts were used in the construction of vascular access for hemodialysis. The indication for the use of an arterial substitute was the unavailability of suitable artery or vein for the construction of a standard subcutaneous arteriovenous fistula. Ten of these grafts were placed in the lower extremity while the rest were placed in either the forearm or upper arm.

Binding of [3H]narciclasine to eukaryotic ribosomes. A study on a structure-activity relationship.

[3H]Narciclasine is a specific inhibitor of peptide bond formation on eukaryotic ribosomes and binds to 60-S ribosomal subunits. Binding of [3H]-narciclasine to yeast ribosomes is inhibited by many other inhibitors of peptide bond formation including anisomycin, several sequiterpene antibiotics (trichodermin, trichothecin, fusarenon X and verrucarin A) several Cephalotaxus alkaloids (harringtonine, homoharringtonine and isoharringtonine), several Amaryllidaceae alkaloids (pretazettine, haemanthamine, lycorine, pseudolycorine and dihydrolycorine) and the narciclasine derivatives trans-dihydronarciclasine, trans-dihydronarciclasine acetonide and isonarciclasine. Binding is also inhibited, although to a very small extent, by methylnarciclasine and cisdihydronarciclasine.

Strictures of the ileal loop.

Intrinsic ileal loop strictures in children are much more common than previously reported. They occur late and are usually clinically silent. Their etilogy is inflammatory rather than ischemic and a local immunosuppressive effect of urine also may play a role.

Endothelial injury. Association with elevations of serum bile acid and cholesterol concentration in biliary-obstructed rats.

An association between atherosclerosis, biliary obstruction and hyperlipidemia has been reported in the literature. In previous study from this laboratory, ultrastructural evidence of coronary artery endothelial damage was obtained in rats following ligation-induced biliary obstruction. In the present investigation, serum bile acids, total cholesterol and alkaline phosphatase levels were studied in association with similarly induced biliary obstruction and related to electron-microscopic observations of coronary artery endothelium.