Functional assessment of genetic variants in thrombomodulin detected in patients with bleeding and thrombosis.

Thrombomodulin (TM) expressed on endothelial cells regulates coagulation. Specific nonsense variants in the TM gene, THBD, result in high soluble TM levels causing rare bleeding disorder. In contrast, though THBD variants have been associated with venous thromboembolism, this association remains controversial.

Multi-Gene Panel for Thrombophilia Testing in Venous Thromboembolism.

Background: Conventional tests for inherited thrombophilia focus on the five most-established inherited thrombophilias; i.e. deficiencies in antithrombin, protein C, and protein S, and the factor V Leiden and prothrombin G20210A variants.

Time Tetris: a longitudinal study on compressed schedules and workplace well-being at IKEA.

Background: Compressed schedules, where workers perform longer daily hours to enjoy additional days off, are increasingly promoted as a workplace well-being intervention. Nevertheless, their implications for work-related well-being outcomes, such as recovery from work and burnout risk, are understudied. This gap leaves employers with little evidence on whether and how the arrangement contributes to workplace well-being.

Mental health of sexual assault victims and predictors of their use of support from in-house psychologists at Belgian sexual assault care centres.

Background: Sexual assault (SA) can induce a negative impact on victims' mental health. Specialised SA services generally offer medical care and a forensic examination to SA victims. However, there is a large variation in how these services provide mental health support.

Disclosing the 'Big C': what does cancer survivorship signal to employers?

To study hiring discrimination against cancer survivors, we conduct a vignette experiment in which American and British professionals recruited via Prolific evaluate fictitious job candidates. Candidates differed by periods of non-employment in their career, including non-employment due to suffering from cancer. We study the effect of cancer experiences on professionals' hirability ratings, as well as its effect on underlying candidate perceptions, related to various potential forms of stigma identified in the literature.

Factors Related to Police Reporting in Sexual Assault Care Centers: Are We Underestimating the Role of Support Persons?

Few victims of sexual assault (SA) report to the police. Research on the role of support persons in victims' reporting is sparse. We address this gap by examining the association of victim, assailant, victimization incident, and support characteristics with reporting rates among victims attending sexual assault care centers (SACCs).

Costly mistakes: Why and when spelling errors in resumes jeopardise interview chances.

The analysis of hiring penalties due to spelling errors has been restricted to white-collar occupations and error-laden resumes. Moreover, the mechanisms underlying these penalties remained unclear. To fill these gaps, we conducted a scenario experiment with 445 recruiters.

Beyond the Hype: (How) Are Work Regimes Associated with Job Burnout?

Job burnout affects countless workers and constitutes a major issue in working life. Prevention strategies such as offering part-time options and shorter working weeks have been widely advocated to address this issue. However, the relationship between shorter work regimes and burnout risk has not yet been investigated across diverse working populations applying validated measures and frameworks for job burnout.

Clinical application of multigene panel testing for bleeding, thrombotic, and platelet disorders: a 3-year Belgian experience.

Background: The international study ThromboGenomics has evaluated the diagnostic rate using a targeted multigene panel test for the screening of inherited bleeding, thrombotic and platelet disorders.

Objectives: We retrospectively analyzed the results of the implementation of genetic testing for inherited bleeding, thrombotic and platelet disorders in Belgian clinical practice and evaluated possible reclassification of reported variants.

Patients/methods: We implemented a Thrombosis-Hemostasis multigene panel test using whole exome sequencing to diagnose 487 patients recruited by 27 different Belgian hospitals with the implementation of stringent laboratory accreditation standards and by studying up to 100 diagnostic-grade genes.

Introducing a vignette experiment to study mechanisms of ethnic discrimination on the housing market.

Ethnic discrimination on the housing market has been subject of research for years. While a field experimental approach is widespread, alternative attempts to objectively measure mechanisms of discrimination on the housing market are scarce. In line with labor market research, we stress that to reduce rental discrimination against ethnic minorities, we need understanding its underlying mechanisms.

The protective role of wallowing against heat stress in gestating and lactating sows housed outdoors.

The objective of this study was to describe the physiological response of gestating and lactating sows to naturally-occurring environmental conditions, and to identify factors that may contribute to or prevent heat stress, while being kept outdoors in Québec, Canada during the summer. Six groups of 4 Yorkshire-Landrace sows lived in outdoor pens equipped with a wallow, shade structure, farrowing huts and access to a pasture from July to September 2018. Between week 15 of gestation and week 3 of lactation (inclusive), we recorded the location of each sow 5 days/week during 5 daily 15-min observation periods, and additionally measured the sow's respiratory rate and mud cover at the end of each observation period.

The COVID-19 crisis and telework: a research survey on experiences, expectations and hopes.

While a considerable number of employees across the globe are being forced to work from home due to the COVID-19 crisis, it is a guessing game as to how they are experiencing this current surge in telework. Therefore, we examined employee perceptions of telework on various life and career aspects, distinguishing between typical and extended telework during the COVID-19 crisis. To this end, we conducted a state-of-the-art web survey among Flemish employees.

Successful return to work after burnout: an evaluation of job, person- and private-related burnout determinants as determinants of return-to-work quality after sick leave for burnout.

Purpose: Burnout literature has primarily studied determinants and rehabilitation. Remarkably, ways to enable qualitative return to work after burnout are considered considerably less and were studied here. Specifically, building on the Job Demands-Resources model and Effort-Recovery model, this study investigated determinants of the quality of return to work.

As if it weren't hard enough already: Breaking down hiring discrimination following burnout.

Hiring discrimination towards (former) burnout patients has been extensively documented in the literature. To tackle this problem, it is important to understand the underlying mechanisms of such unequal hiring opportunities. Therefore, we conducted a vignette experiment with 425 genuine recruiters and jointly tested the potential stigma against job candidates with a history of burnout that were mentioned earlier in the literature.

Piloting sexual assault care centres in Belgium: who do they reach and what care is offered?

Background: Sexual assault (SA) is highly prevalent in Belgium. In order to mitigate the negative consequences for victims of acute SA, Sexual Assault Care Centres (SACCs) were piloted from October 2017 to October 2018 in three Belgian hospitals. SACCs offer medical and psychological care, forensic examination and the possibility to report to the police at the SACC.

How do employees think the COVID-19 crisis will affect their careers?

This study is the first in the world to investigate the expected impact of the COVID-19 crisis on career outcomes and career aspirations. To this end, high-quality survey research with a relevant sample of Flemish (Belgian) employees was conducted. About 21% of them fear losing their jobs due to the crisis-14% are concerned that they will even lose their jobs in the near future.

Does loneliness lurk in temp work? Exploring the associations between temporary employment, loneliness at work and job satisfaction.

This research contributes to the limited literature concerning the determinants of loneliness at work, as well as to the literature on psychological outcomes associated with temporary work. More specifically, we are adding to the literature by exploring whether there is an association between working temporarily and loneliness at work and whether loneliness at work partly explains the association between working temporarily and job satisfaction. To this end, we analyse-by means of a mediation model-a unique sample of Flemish employees in the private sector.

Shallow-depth sequencing of cell-free DNA for Hodgkin and diffuse large B-cell lymphoma (differential) diagnosis: a standardized approach with underappreciated potential.

Shallow-depth sequencing of cell-free DNA, a cheap and standardized approach to obtain molecular information on tumors non-invasively, is insufficiently explored for lymphoma diagnosis and disease follow-up. This study collected 318 samples, including longitudinal liquid and paired solid biopsies, from a prospectively recruited cohort of 38 Hodgkin lymphoma (HL) and 85 aggressive B-cell non- HL patients, represented by 81 diffuse large B-cell lymphoma (DLBCL) cases. Following sequencing, copy number alterations and viral read fractions were derived and analyzed.

Twelve eyes see more than eight. Referee bias and the introduction of additional assistant referees in soccer.

This study is the first to investigate whether the introduction of additional assistant referees in the UEFA Europa League (2009-2010 season) and the UEFA Champions League (2010-2011 season) was associated with lower referee bias in terms of home and "big" team favouritism. To this end, we analyse a unique database with pre- and within-game characteristics of all games in seven recent seasons in these leagues by means of bivariate probit regression models. We find evidence for substantial referee bias before the introduction of additional referees, while no such evidence is found after the introduction.

Younger, dissatisfied, and unhealthy - Relative age in adolescence.

We investigate whether relative age (i.e. the age gap between classmates) affects life satisfaction and health in adolescence.

Yawning while scrolling? Examining gender differences in the association between smartphone use and sleep quality.

The negative consequences of deteriorated sleep have been widely acknowledged. Therefore, research on the determinants of poor sleep is crucial. A factor potentially contributing to poor sleep is the use of a smartphone.

Voting with your wallet? Municipal budget policy and election results.

In this research letter, we examine the impact of municipal budget policy on the percentage of votes for the incumbent majority parties in subsequent elections. We contribute to the academic literature by examining the combined influence of taxes, expenditures and debt. Based on data for Flanders (Belgium) between 1994 and 2012, we find no significant association between these budget variables and the actual election results.

And at the end, the Germans always win, don't they? An evaluation of country-specific scoring behaviour in the dying seconds of international club soccer games.

This article contributes to the literature on performance determinants in soccer by investigating country differences in goal scoring in the dying seconds of international soccer games (i.e. in the 90th minute or later).

Too sick or not too sick? The importance of stress and satisfaction with supervisor support on the prevalence of sickness presenteeism.

In a sample of 3274 full-time Belgian workers, this article found that 62% of workers went to work while being sick (sickness presenteeism) at least once over the past 12 months. Of all workers who did not show sickness presenteeism themselves, another 6 out of 10 saw or heard about sickness presenteeism in their own organization. Women were more likely to report sickness presenteeism than men and junior workers were more prone to sickness presenteeism than senior workers.