The study investigates sperm DNA damage in patients with isolated teratozoospermia and its relationship to oxidative stress compared to normozoospermic donors.
Results show increased sperm DNA damage, malondialdehyde, and iron levels in teratozoospermic patients, alongside significantly lower antioxidant enzyme activity.
The findings suggest that reduced antioxidant status and elevated levels of lipid peroxidation and iron negatively impact sperm health, leading to DNA breaks and poor sperm morphology.