Human Osteoblast Migration in DC Electrical Fields Depends on Store Operated Ca-Release and Is Correlated to Upregulation of Stretch-Activated TRPM7 Channels.

Fracture healing and bone regeneration, particularly in the elderly, remains a challenge. There is an ongoing search for methods to activate osteoblasts, and the application of electrical fields is an attractive approach in this context. Although it is known that such electromagnetic fields lead to osteoblast migration and foster mesenchymal osteogenic differentiation, so far the mechanisms of osteoblast activation remain unclear.

Modeling and simulation of platelet reaction and diffusion towards an electro-stimulating dental implant.

Electrical stimulation (ES) has been used clinically to promote bone ingrowth on implant surface. The osseointegration of biomaterials in bone requires complex biological interactions between different bone cells species. At the early stages of bone healing, it is reported in literature that platelets play an important role in stimulating stem cells, osteogenic cells and osteoblasts.