Publications by authors named "Baccouche H"
Article Synopsis
- - The patient is a 58-year-old with a history of stage III-A IgG Kappa multiple myeloma, diagnosed in 2016, who experienced a relapse in 2022 and subsequently developed a large spontaneous hematoma requiring surgery.
- - He presented normal platelet counts and hemostasis but was diagnosed with acquired factor XIII deficiency and thrombopathy, creating diagnostic challenges due to the lack of specific tests for the Factor XIII B subunit.
- - Despite treatments like transfusions and corticosteroids, the effectiveness was limited, and factors fluctuated without symptoms, ultimately making the patient ineligible for autograft due to the risk of hemorrhage.
Article Synopsis
- Platelet count is essential for clinical decisions, but the impedance technique (PLT-I) may overestimate counts in cases of microcytosis, prompting a comparison with the optical technique (PLT-O).
- A study analyzed blood samples with microcytosis (MCV<80 fL) and found a strong correlation between PLT-I and PLT-O for platelet values below 150 x 10^9/L, though a bias of 16.53 x 10^9/L was noted.
- The research suggests that while impedance can be used routinely, the optical technique should be used for samples with MCV<72.9 fL or when schizocytes are present to ensure accurate hemogram validation.
Background: Over the past decades, thrombophilia testing in patients with venous thrombo-embolism has increased tremendously. However, the role of inherited thrombophilie in prediction the risk of recurrence remains controversial. Consequently, it is still unclear whether thrombophilia testing influences decisions regarding duration of anticoagulation in clinical practices.
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- - This study investigates the effectiveness of different aspirin dosing regimens in diabetic patients who suffered from non-ST elevation acute coronary syndrome (NSTE-ACS) by measuring the body's ability to generate thrombin.
- - A total of 59 diabetic patients were randomly assigned to one of three treatment groups: 100 mg once daily, 160 mg once daily, or 100 mg twice daily, with outcomes assessed at discharge and six months later.
- - Results indicated that while the once-daily aspirin doses had no significant impact on thrombin generation over time, the twice-daily regimen significantly reduced thrombin levels, suggesting better management of hypercoagulability in these patients.
Background: Multiple myeloma is a hematologic malignancy which confers a high venous thromboembolic risk. This risk is linked to patient-related factors, disease-specific mechanisms, and antimyeloma therapy, especially immunomodulatory drugs. Some studies have suggested that the thrombin generation assay may be a predictive marker of thrombosis.
View Article and Find Full Text PDFBackground And Aim: The effects of Ramadan fasting on health are a little controversial. The present study is aimed at evaluating the metabolic effects on a group of 517 patients with ≥2 cardiovascular risk factors over a period running from 2012 to 2014.
Methods: Each patient was assessed at three visits: before, during, and after Ramadan.
Introduction And Objectives: For long, bleeding in cirrhotic patients has been associated with acquired coagulation disorders. The aim of our study was to investigate the impact of acquired coagulation disorders on bleeding risk in cirrhotic patients.
Materials And Methods: Blood samples were collected from 51 cirrhotic patients with (H+) or without (H-) bleeding events and 50 controls matched by age and sex.
Article Synopsis
- Ramadan fasting impacts aspirin resistance primarily in patients with type 2 diabetes mellitus, where an increase in aspirin resistance was observed during and after the fasting period.
- The study included 177 patients with cardiovascular risk factors, and no significant changes were found in those without diabetes.
- Results indicated that diabetic patients experienced significant increases in glycemia, triglycerides, and cholesterol during Ramadan, which normalized post-fasting, suggesting a need for monitoring in this group.
Background: Data on the effect of fasting on coronary disease are rare and controversial. The aim of our study was to investigate the influence of Ramadan on the prevalence of acute coronary syndrome among chest pain patients in the emergency department of Monastir.
Methods: It was a prospective study, performed in the emergency department of Fattouma Bourguiba University Hospital of Monastir, during the 3 months before, during and after Ramadan from 2012 to 2014.
What Is Known And Objective: The international normalized ratio (INR) is widely used to monitor patients on vitamin K antagonists. This study aimed to assess the agreement of INR values obtained with different thromboplastin/instrument combinations.
Material And Methods: International normalized ratio was determined on plasmas from 330 patients undergoing antivitamin K treatment (with acenocoumarol), using two calibration methods and four reagent/instrument combinations: Both Neoplastine CI and Neoplastine CI Plus on STA-R instrument from Diagnostica STAGO, Asnières, France; and both Thromborel S and Innovin on SYSMEX 2100i instrument from Siemens Health Care Diagnostics, Marbung, Germany.
Background: Data on the effect of fasting on coronary disease are rare and controversial. The aim of our study was to investigate the influence of Ramadan on the prevalence of acute coronary syndrome among chest pain patients in the emergency department of Monastir.
Methods: It was a prospective study, performed in the emergency department of Fattouma Bourguiba University Hospital of Monastir, during the 3 months before, during and after Ramadan from 2012 to 2014.
Background: The effects of Ramadan fasting (RF) on clopidogrel antiplatelet inhibition were not previously investigated. The present study evaluated the influence of RF on platelet reactivity in patients with high cardiovascular risk (CVR) in particular those with type 2 diabetes mellitus (DM).
Methods: A total of 98 stable patients with ≥2 CVR factors were recruited.
Introduction: It has been recently suggested that microparticles (MP) play a role in the pathogenesis of thrombotic complications. This study aimed to assess the contribution of procoagulant activity expressed by circulating MP in thrombotic events in MPN patients.
Methods: Seventy-four MPN patients were enrolled in a trans-sectional study.
Introduction: Despite its lifesaving role, blood transfusion still has risks associated with it. Hemovigilance is a set of surveillance procedures of the transfusion chain intended to promote safe and effective use of blood components. This work aims to present a descriptive analysis of adverse reactions, which were notified over a period of 5 years (incidence and etiology); to identify malfunctions and to propose corrections.
View Article and Find Full Text PDFCerebral Venous Thrombosis: A Tunisian Monocenter Study on 160 Patients.
Clin Appl Thromb Hemost
November 2017
Objective: Data regarding cerebral venous thrombosis in North Africa are scarce. This study aims to identify the clinical features, risk factors, outcome, and prognosis of cerebral venous thrombosis in Tunisia.
Methods: Data of 160 patients with radiologically confirmed cerebral venous thrombosis, hospitalized in Mongi Ben Hmida National Institute of Neurology (Tunis, Tunisia), were retrospectively collected and analyzed.
Background: Acupuncture is one of the oldest techniques to treat pain and is commonly used for a large number of indications. However, there is no sufficient evidence to support its application in acute medical settings.
Methods: This was a prospective, randomized trial of acupuncture vs morphine to treat ED patients with acute onset moderate to severe pain.
Despite the prolongation of coagulation tests, recent studies reported an increased frequency of thromboembolic events in patients with cirrhosis. The aim of this study was to evaluate the haemostatic balance in cirrhotic patients through assessing the variation of pro- and anticoagulant factors and evaluating the in-vitro thrombin generation in patients with cirrhosis and in healthy patients. Fifty-one cirrhotic patients with or without thromboembolic events and 50 controls matched by age and sex were enrolled.
View Article and Find Full Text PDFBackground: BCR-ABL negative myeloproliferative neoplasms (MPN) include polycythemia Vera (PV), essential thrombocythemia (ET) and primitive myelofibrosis (PMF). the JAK2 V617F mutation has been introduced since 2008 as a major diagnostic criterion on the one hand and on the other hand, it would be linked to increased risk of thrombotic complications.
Aim: This study aimed to evaluate the association of JAK2 mutation and thrombotic events in MPN.
Background: Urbanization and adoption of new diet and lifestyles had increased the cardiovascular risk factor (CVRF) rate and therefore, acute coronary syndrome (ACS) in developing countries such as Tunisia. We aimed at determining ACS prevalence among a sample of Tunisian patients with chest pain, at establishing the standardized incidence rate (SIR) of ACS, and at quantifying the relationship between ASC and CVRF in this population.
Methods: We studied 3158 patients admitted to a chest pain unit for non-traumatic chest pain collected in Emergency Data from January 2012 to December 2014.
Background: The management of urolithiasis in patients with haemophilia poses a real challenge to the urologist.
Aim: We conducted a systematic literature review to assess the safety and efficacy of extracorporeal shock wave lithotripsy (ESWL) in the treatment of urolithiasis in hemophiliacs.
Methods: A systematic review was conducted by using the National Library of Medicine (PubMed) search engine between January 1985 and June 2013.
[28-year-old man with fever and abnormalities in chest radiograph].
Dtsch Med Wochenschr
February 2013
Background: Blood transfusion is a high risk activity.
Aim: To evaluate transfusion safety in planned cardiac surgery.
Methods: This study was conducted in the blood bank of the Rabta Hospital in two phases: a phase to observe transfusion acts followed by corrective actions and a phase to evaluate the impacts of these corrections on the transfusion practices.
Article Synopsis
- * Protein C and S deficiencies were linked to a higher risk of MI (with statistically significant results) and were also associated with increased chances of developing venous thrombosis and pulmonary embolism during patient follow-up.
- * The research suggests that deficiencies in Protein C and S can contribute to MI and other thromboembolic events, but the therapeutic approaches to addressing these deficiencies remain debated and unclear.
Introduction: Cardiac amyloidosis (CA) and hypertrophic cardiomyopathy (HCM) are important differential diagnosis of left ventricular hypertrophy. The aim of this study was to investigate if three-dimensional (3D) speckle tracking-derived functional parameters enabled differentiation of CA and HCM by a disease-specific pattern.
Methods: Twelve patients with CA and 12 patients with HCM were included.
Identification of outpatients with high platelet reactivity (HPR) on antiplatelet treatment is an unmet need. The present study was conducted in healthy individuals (n = 50) and in outpatients with coronary artery disease (CAD) at a distance from the acute ischemic episode (aspirin group, n = 71; aspirin/clopidogrel group, n = 106). We studied the feasibility and the precision of whole blood multiple electrode aggregometry (MEA) after triggering platelet aggregation by arachidonic acid or adenosine diphospate (ADP).
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