Seasonal observations on the influence of groundwater discharge on meiofaunal assemblages in subterranean estuaries of southwest India.

The submarine groundwater discharge (SGD) into the sea is known to alter various biotic and abiotic properties of coastal waters. However, its influence on the lower trophic levels, namely, meiofauna, is poorly understood. This study highlights the impact of SGD on the density, distribution, and diversity of intertidal meiofaunal communities along the subterranean estuaries (STEs) of the southwest coast of India (Arabian Sea).

Nanoparticles Induced Biomimetic Remineralization of Acid-Etched Dentin.

Statement Of The Problem: Dentin bonding with etch-and-rinse adhesives involves demineralizing the 5-8µm of the surface dentin to create micro space for resin infiltration. The presence of continuous fluid movement in dentin tubules and positive pulpal pressure prevents complete water replacement by resin monomers. This results in areas of demineralized dentin, which contain collagen fibers without resin infiltration.

Breaking the storm: ruxolitinib as a lifeline in refractory hemophagocytic lymphohistiocytosis with macrophage activation syndrome.

This case report presents the management of a 25-year-old woman with refractory hemophagocytic lymphohistiocytosis (HLH) secondary to adult-onset Still's disease. Despite initial treatment with corticosteroids and biologic therapies, including anakinra and tocilizumab, her condition continued to deteriorate, necessitating intensive care unit admission. Following multidisciplinary consultation, ruxolitinib therapy, a Janus kinase (JAK) inhibitor targeting hyperinflammation, was initiated.

Computational and experimental insights into pharmacological potential: Synthesis, in vitro evaluation, and molecular docking analysis of bioactive urea and thiourea derivatives.

This study delves into the synthesis, in vitro assessment, and molecular docking analysis of bioactive urea and thiourea derivatives, which have garnered significant attention in pharmaceutical chemistry due to their versatile chemical reactivity and potential therapeutic applications One pot synthetic approach was utilized to develop a diverse class of these compounds. Subsequent biological assessments, including antimicrobial assays, demonstrated their pharmacological potential by inhibiting pathogenic microorganisms. Molecular docking analysis offered computational insights into the interactions between these compounds and specific biomolecules, shedding light on their potential mechanisms of action.

Necrolytic migratory erythema: a fortuitous diagnosis.

A woman in her late 60s presented with widespread, itchy, dark lesions over her trunk and legs for 1 month. Initially, she was managed as nutritional dermatitis and experienced partial improvement. However, her condition worsened over 2 months, characterised by aggravated skin lesions, new-onset diabetes and a 12 kg weight loss.

Affinity-tuned mesothelin CAR T cells demonstrate enhanced targeting specificity and reduced off-tumor toxicity.

The application of chimeric antigen receptor (CAR) T cell therapy in solid tumors is hindered by life-threatening toxicities resulting from on-target, off-tumor killing of nonmalignant cells that express low levels of the target antigen. Mesothelin (MSLN) has been identified as a target antigen for CAR T cell treatment of mesothelioma, lung, ovarian, and other cancers because of its high expression on tumor cells and limited expression on mesothelial cells. However, fatal off-tumor toxicity of high-affinity MSLN-targeting CAR T cells has been reported in multiple clinical trials.

Effect of supplementation of distillers' dried grain with solubles (DDGS) to a straw-based diet on performance, carcass characteristics, and meat quality in Nellore ram lambs.

Distillers dried grains with solubles (DDGS), a byproduct of ethanol production, has gained recognition as a viable alternative feed supplement for ram lambs because of its nutritional profile and cost-effectiveness. This study evaluated the effect of supplementing straw-based diets with different levels of DDGS on the growth performance and economic viability of growing ram lambs. A total of 24 ram lambs (16.

Exploring MoS Growth: A Comparative Study of Atmospheric and Low-Pressure CVD.

Transition-metal dichalcogenides (TMDs), in particular MoS, have garnered a lot of interest due to their unique properties and potential applications. Chemical vapor deposition (CVD) is generally used to synthesize 2D films of MoS. The synthesis of MoS is highly sensitive to growth parameters such as temperature, pressure, flow rate, precursor ratio, etc.

Etiology, Clinical Profile and Factors Predicting Disease Recurrence of Rhinosporidiosis in a Tertiary Care Centre in Kanyakumari District.

Rhinosporidiosis is a chronic granulomatous disease caused by Rhinosporidium seeberi, typically involving nasal cavity and nasopharynx. They usually present with epistaxis, nasal obstruction, anosmia, and headache. In India, it is endemic in coastal areas of Orissa, Tamil Nadu, Kerala, Karnataka and Pondicherry states.

Visible light responsive heterophase Titania monoliths for the fast and efficient photocatalytic decontamination of organic pollutants.

The article reports the synthesis of an ordered mesoporous network of heterophase TiO monoliths as a visible light-responsive photocatalyst using tri-block copolymers of Pluronic F108, P123 and F127 as structure-directing agents (SDAs) and temperature-controlled calcination (450-650 °C) has been carried out by direct templating-assisted hydrothermal approach. The structural/surface morphology and topographical properties of the photocatalyst are characterized using FE-SEM-EDAX, HR-TEM-SAED, p-XRD, VB-XPS, PLS, TG/DTA, UV-Vis-DRS, BET/BJH and zeta potential analysis. The undoped heterophase mesoporous TiO monoliths with in-built lattice/surface defects exhibit visible light photocatalytic properties, successfully dissipating Reactive Brown 10 (RB-10) dye.

Transient Photocurrent Responses of SrCeTiO Perovskites Under Visible Light Illumination for Photovoltaic Applications.

The objective of this study was to synthesize strontium titanate (SrCeTiO) doped with Ce by solid state method. Its crystalline structure is SrCeTiO, and its bandgap ranges from ~3.3 to ~2.

The Interaction of Myeloperoxidase with the Industrial Contaminant 6-PPD: A Potential Pathway for Reactive Metabolites.

6-PPD (-[1,3-dimethylbutyl]-'-phenyl--phenylenediamine) is an industrial antioxidant reported to be an environmental contaminant. It was found to be highly toxic to coho salmon and potentially other aquatic organisms. The toxicity of 6-PPD in humans, however, remains unknown.

VEXAS syndrome unveiled: a multidimensional journey from clinical presentation to management.

An 83-year-old man with a history of monoclonal gammopathy of unknown significance, macrocytic anemia, and cytopenias presented with hemorrhagic bullae on his left hand, alongside intermittent fevers and joint pain. Laboratory findings indicated anemia, elevated mean corpuscular volume, thrombocytopenia, leukopenia, and a high C-reactive protein level. A biopsy of the bullae showed neutrophilic dermatosis, and computed tomography scans of the thorax revealed lung opacities and mediastinal lymphadenopathy, suggesting neutrophilic alveolitis.

MICAL2 Is a Super Enhancer Associated Gene that Promotes Pancreatic Cancer Growth and Metastasis.

Pancreatic ductal adenocarcinoma (PDAC) remains one of the deadliest solid cancers and thus identifying more effective therapies is a major unmet need. In this study we characterized the super enhancer (SE) landscape of human PDAC to identify novel, potentially targetable, drivers of the disease. Our analysis revealed that is a super enhancer-associated gene in human PDAC.

Efficient deletion of microRNAs using CRISPR/Cas9 with dual guide RNAs.

MicroRNAs (miRNAs) are short non-coding RNAs that play crucial roles in gene regulation, exerting post-transcriptional silencing, thereby influencing cellular function, development, and disease. Traditional loss-of-function methods for studying miRNA functions, such as miRNA inhibitors and sponges, present limitations in terms of specificity, transient effects, and off-target effects. Similarly, CRISPR/Cas9-based editing of miRNAs using single guide RNAs (sgRNAs) also has limitations in terms of design space for generating effective gRNAs.

Exploration of 'micro' level factors that affect the involvement of clinical pharmacists in interprofessional ward rounds in hospitals: Through the lens of social cognitive theory.

Background: Macro and meso level factors that influence the participation by clinical pharmacists in ward rounds include pharmacy management culture, commitment to ward rounds and adequate time for ward rounds being included in workload models. The 'micro' level factors that affect the involvement of clinical pharmacists in ward rounds have not been widely explored.

Objective: Explore 'micro' level factors to gain insight into clinical pharmacists' participation in interprofessional ward rounds in inpatient settings through the lens of social cognitive theory.

Baseline findings of a multicentric ambispective cohort study (2021-2022) among hospitalised mucormycosis patients in India.

In India, the incidence of mucormycosis reached high levels during 2021-2022, coinciding with the COVID-19 pandemic. In response to this, we established a multicentric ambispective cohort of patients hospitalised with mucormycosis across India. In this paper, we report their baseline profile, clinical characteristics and outcomes at discharge.

A review on the traditional uses, nutritive importance, pharmacognostic features, phytochemicals, and pharmacology of Hook F.

Hook F. (MC), belonging to the family Cucurbitaceae, is a plant with several biological activities. This detailed, comprehensive review gathers and presents all the information related to the geographical distribution, morphology, therapeutic uses, nutritional values, pharmacognostic characters, phytochemicals, and pharmacological activities of MC.

Enhancement of α-galactosidase production using novel Actinoplanes utahensis B1 strain: sequential optimization and purification of enzyme.

α-Galactosidase is an important exoglycosidase belonging to the hydrolase class of enzymes, which has therapeutic and industrial potential. It plays a crucial role in hydrolyzing α-1,6 linked terminal galacto-oligosaccharide residues such as melibiose, raffinose, and branched polysaccharides such as galacto-glucomannans and galactomannans. In this study, Actinoplanes utahensis B1 was explored for α-galactosidase production, yield improvement, and activity enhancement by purification.

Clinical Profile and Factors Associated with Adverse Outcomes in Coronavirus Disease 2019-associated Mucormycosis: A Single-centre Study.

: The coronavirus disease 2019 (COVID-19) pandemic was associated with an increased incidence of mucormycosis globally. However, the clinical pattern, epidemiologic features and risk factors for adverse outcomes are not well established. : We performed a retrospective analysis of the data from patients hospitalized with proven mucormycosis between April 2021 and August 2021.

Adenosine triphosphate induced cell death: Mechanisms and implications in cancer biology and therapy.

Adenosine triphosphate ATP) induced cell death (AICD) is a critical cellular process that has garnered substantial scientific interest for its profound relevance to cancer biology and to therapeutic interventions. This comprehensive review unveils the intricate web of AICD mechanisms and their intricate connections with cancer biology. This review offers a comprehensive framework for comprehending the multifaceted role of AICD in the context of cancer.