Metal-free functionalization of tyrosine residues in short peptides and study of the morphological alterations.

An efficient functionalization of tyrosine residues in phenolic regions is achieved under metal-free conditions. The strategy involves the conversion of a tyrosine residue to 4-amino phenylalanine or 4-amino-3-methoxy phenylalanine in short peptides through a controlled oxidative dearomatization. This transformation is achieved in one pot with good yields and excellent regioselectivity.

Diastereoselective synthesis of CF-dihydrobenzofurans by [4+1] annulation of -generated CF--quinone methides and sulfur ylides.

An efficient and highly diastereoselective synthesis of CF-dihydrobenzofurans by the reaction of -generated CF-QMs in the presence of a base with sulphur ylides is put forward. The generality of the present developed method was well studied with diverse substrates to access the corresponding products in excellent yields. The highly reactive CF-QM has been utilized first time for the annulation reaction.