Frequency-Dependent Squeezed Vacuum Source for the Advanced Virgo Gravitational-Wave Detector.

In this Letter, we present the design and performance of the frequency-dependent squeezed vacuum source that will be used for the broadband quantum noise reduction of the Advanced Virgo Plus gravitational-wave detector in the upcoming observation run. The frequency-dependent squeezed field is generated by a phase rotation of a frequency-independent squeezed state through a 285 m long, high-finesse, near-detuned optical resonator. With about 8.

"I hope to all the world they don't forget women of Afghanistan": An interrupted survey among doctors in Afghanistan.

Objective: To assess current access to essential sexual and reproductive health (SRHR) services in Afghanistan and how access has changed with the transition of power.

Methods: This is a cross-sectional study based on data from an anonymous survey among doctors in Afghanistan in May 2022, analyzed using descriptive statistics. The survey recorded subjective estimates of access to SRHR services, barriers to access, extent of maternal mortality or near miss due to preventable factors, and the effect of the regime change on access.

Brain Waves Analysis Via a Non-Parametric Bayesian Mixture of Autoregressive Kernels.

The standard approach to analyzing brain electrical activity is to examine the spectral density function (SDF) and identify frequency bands, defined a priori, that have the most substantial relative contributions to the overall variance of the signal. However, a limitation of this approach is that the precise frequency and bandwidth of oscillations are not uniform across different cognitive demands. Thus, these bands should not be arbitrarily set in any analysis.

The Impact of Chronic Kidney Disease in Patients With Locally Advanced Rectal Cancer Treated With Neoadjuvant Chemoradiation.

Background: Patients with chronic kidney disease are commonly excluded from clinical trials. The impact of chronic kidney disease on outcomes in patients with locally advanced rectal cancer has not been previously studied.

Objective: This study aimed to investigate the impact of chronic kidney disease on outcomes in patients with locally advanced rectal cancer.

Malignant Melanoma within a Cellular Blue Nevi Presenting as a Vascular Malformation and the Connection to Sporadic KRAS Mutations.

We present a case of malignant melanoma (MM) developing within a vascular malformation showing features of cellular blue nevi. A 47-year-old male presented with acute symptoms of a temporal and zygomatic mass, which were both previously asymptomatic upon development 30 years ago. These masses were diagnosed as vascular malformations upon imaging and were treated with sclerotherapy.

Constraints on Cosmic Strings Using Data from the Third Advanced LIGO-Virgo Observing Run.

We search for gravitational-wave signals produced by cosmic strings in the Advanced LIGO and Virgo full O3 dataset. Search results are presented for gravitational waves produced by cosmic string loop features such as cusps, kinks, and, for the first time, kink-kink collisions. A template-based search for short-duration transient signals does not yield a detection.

[EOSINOPHILIC CATION PROTEIN AS A SENSITIVE BIOMARKER OF EOSINOPHILIC INFLAMMATION AND A PREDICTOR OF SEVERE COPD].

It has been established that the eosinophilic phenotype of COPD is separate phenotype of the disease. The results of some studies demonstrate the possibility that may presence a phenotype with an increased level of eosinophil activity. To study the relationship between the blood ECP level and the characteristics of the course of COPD, we examined 161 patients with COPD aged from 40 to 70 years old, smoking index> 10 pack-years, no history of atopy, total blood Ig E <100 IU / ml.

Detectable Environmental Effects in GW190521-like Black-Hole Binaries with LISA.

GW190521 is the compact binary with the largest masses observed to date, with at least one black hole in the pair-instability gap. This event has also been claimed to be associated with an optical flare observed by the Zwicky Transient Facility in an active galactic nucleus (AGN), possibly due to the postmerger motion of the merger remnant in the AGN gaseous disk. The Laser Interferometer Space Antenna (LISA) may detect up to ten such gas-rich black-hole binaries months to years before their detection by Laser Interferometer Gravitational Wave Observatory or Virgo-like interferometers, localizing them in the sky within ≈1°^{2}.

Quantum Backaction on kg-Scale Mirrors: Observation of Radiation Pressure Noise in the Advanced Virgo Detector.

The quantum radiation pressure and the quantum shot noise in laser-interferometric gravitational wave detectors constitute a macroscopic manifestation of the Heisenberg inequality. If quantum shot noise can be easily observed, the observation of quantum radiation pressure noise has been elusive, so far, due to the technical noise competing with quantum effects. Here, we discuss the evidence of quantum radiation pressure noise in the Advanced Virgo gravitational wave detector.

Prospects for observing and localizing gravitational-wave transients with Advanced LIGO, Advanced Virgo and KAGRA.

We present our current best estimate of the plausible observing scenarios for the Advanced LIGO, Advanced Virgo and KAGRA gravitational-wave detectors over the next several years, with the intention of providing information to facilitate planning for multi-messenger astronomy with gravitational waves. We estimate the sensitivity of the network to transient gravitational-wave signals for the third (O3), fourth (O4) and fifth observing (O5) runs, including the planned upgrades of the Advanced LIGO and Advanced Virgo detectors. We study the capability of the network to determine the sky location of the source for gravitational-wave signals from the inspiral of binary systems of compact objects, that is binary neutron star, neutron star-black hole, and binary black hole systems.

Dosimetry study on Auger electron-emitting nuclear medicine radioisotopes in micrometer and nanometer scales using Geant4-DNA simulation.

Purpose: Dosimetry of Auger electron-emitting nuclear medicine radioisotopes on cellular and DNA scales is essential in order to assess the biological effects and damage of these radioisotopes to the DNA molecule. This study examined the effects of widely used radioisotopes in nuclear medicine and also two therapeutic radioisotopes in the scale of micrometer and nanometer.

Methods: In this paper, on cell scale (micrometer scale), the -values for widely used Auger electron-emitting diagnostic radioisotopes I, I, Tc, Ga, Tl and In and two therapeutic radioisotopes of I and At in three different geometrical cell models (spherical, elliptical and cubic) were calculated using Geant4-DNA and the results were compared with the results of other simulation codes as well as the MIRD technique.

Synergistic Effect of Nitrogen Doping and Ultra-Microporosity on the Performance of Biomass and Microalgae-Derived Activated Carbons for CO Capture.

We report a unique naturally derived activated carbon with optimally incorporated nitrogen functional groups and ultra-microporous structure to enable high CO adsorption capacity. The coprocessing of biomass ( waste leaves) and microalgae (Spirulina) as the N-doping agent was investigated by probing the parameter space (biomass/microalgae weight ratio, reaction temperature, and reaction time) of hydrothermal carbonization and activation process (via the ZnCl/CO activation) to generate hydrochars and activated carbons, respectively, with tunable nitrogen content and pore sizes. The central composite-based design of the experiment was applied to optimize the parameters of the prehydrothermal carbonization procedure resulting in the fabrication of N-enriched carbonaceous products with the highest possible mass yield and nitrogen content.

Molecular Classification of Diffuse Gliomas.

Technological advances in the field of molecular genetics have improved the ability to classify brain tumors into subgroups with distinct clinical features and important therapeutic implications. The World Health Organization's newest update on classification of gliomas (2016) incorporated isocitrate dehydrogenase 1 and 2 mutations, ATRX loss, 1p/19q codeletion status, and TP53 mutations to allow for improved classification of glioblastomas, low-grade and anaplastic gliomas. This paper reviews current advances in the understanding of diffuse glioma classification and the impact of molecular markers and DNA methylation studies on survival of patients with these tumors.

Increasing the Astrophysical Reach of the Advanced Virgo Detector via the Application of Squeezed Vacuum States of Light.

Current interferometric gravitational-wave detectors are limited by quantum noise over a wide range of their measurement bandwidth. One method to overcome the quantum limit is the injection of squeezed vacuum states of light into the interferometer's dark port. Here, we report on the successful application of this quantum technology to improve the shot noise limited sensitivity of the Advanced Virgo gravitational-wave detector.

Eastern Canadian Gastrointestinal Cancer Consensus Conference 2018.

The annual Eastern Canadian Gastrointestinal Cancer Consensus Conference was held in Halifax, Nova Scotia, 20-22 September 2018. Experts in radiation oncology, medical oncology, surgical oncology, and pathology who are involved in the management of patients with gastrointestinal malignancies participated in presentations and discussion sessions for the purpose of developing the recommendations presented here. This consensus statement addresses multiple topics in the management of pancreatic cancer, pancreatic neuroendocrine tumours, hepatocellular cancer, and rectal and colon cancer, including ■ surgical management of pancreatic adenocarcinoma,■ adjuvant and metastatic systemic therapy options in pancreatic adenocarcinoma,■ the role of radiotherapy in the management of pancreatic adenocarcinoma,■ systemic therapy in pancreatic neuroendocrine tumours,■ updates in systemic therapy for patients with advanced hepatocellular carcinoma,■ optimum duration of adjuvant systemic therapy for colorectal cancer, and■ sequence of therapy in oligometastatic colorectal cancer.

Tests of General Relativity with GW170817.

The recent discovery by Advanced LIGO and Advanced Virgo of a gravitational wave signal from a binary neutron star inspiral has enabled tests of general relativity (GR) with this new type of source. This source, for the first time, permits tests of strong-field dynamics of compact binaries in the presence of matter. In this Letter, we place constraints on the dipole radiation and possible deviations from GR in the post-Newtonian coefficients that govern the inspiral regime.

Constraining the p-Mode-g-Mode Tidal Instability with GW170817.

We analyze the impact of a proposed tidal instability coupling p modes and g modes within neutron stars on GW170817. This nonresonant instability transfers energy from the orbit of the binary to internal modes of the stars, accelerating the gravitational-wave driven inspiral. We model the impact of this instability on the phasing of the gravitational wave signal using three parameters per star: an overall amplitude, a saturation frequency, and a spectral index.

Search for Subsolar-Mass Ultracompact Binaries in Advanced LIGO's First Observing Run.

We present the first Advanced LIGO and Advanced Virgo search for ultracompact binary systems with component masses between 0.2  M_{⊙}-1.0  M_{⊙} using data taken between September 12, 2015 and January 19, 2016.

GW170817: Measurements of Neutron Star Radii and Equation of State.

On 17 August 2017, the LIGO and Virgo observatories made the first direct detection of gravitational waves from the coalescence of a neutron star binary system. The detection of this gravitational-wave signal, GW170817, offers a novel opportunity to directly probe the properties of matter at the extreme conditions found in the interior of these stars. The initial, minimal-assumption analysis of the LIGO and Virgo data placed constraints on the tidal effects of the coalescing bodies, which were then translated to constraints on neutron star radii.