Longitudinal faster anxiety progression of variant carriers in the early Parkinson's disease cohort.

Objective: Anxiety symptoms are prevalent neuropsychiatric manifestations in Parkinson's disease (PD) and impact the development of motor complications. Our aim was to evaluate the association of variants with the anxiety development in early PD cohort.

Methods: This cohort study used data from the Parkinson Progression Marker Initiative.

Clinical analysis of delayed epistaxis following endoscopic sinus surgery.

Objective: To investigate the clinical characteristics and treatment methods associated with delayed epistaxis following endoscopic sinus surgery.

Methods: The clinical data of 46 patients with delayed epistaxis following endoscopic sinus surgery were retrospectively analyzed. To explore the clinical features, pathogenesis, and treatment plan for delayed epistaxis, the postoperative bleeding time, bleeding inducements, systemic complications, surgical approach, the hemorrhage locations and responsible vessels, and treatment methods were analyzed.

[Clinical analysis of 11 cases of CD20 positive extranodal NK/T cell lymphoma].

To explore the clinical features and prognosis of CD20-positive extranodal NK/T cell lymphoma. To analyze the clinical characteristics and prognosis of 11 ENKTL patients admitted to this hospital. Among the 11 patients, 6 cases with elevated LDH, 6 cases of anemia, and 8 cases with Ki-67≥50%.

[Perioperative airway management of nasal endoscopic surgery].

To evaluate the perioperative airway management process of nasal endoscopic surgery, and find clinical evidence for accelerating recovery and reducing respiratory complications. The perioperative airway management process for nasal endoscopic surgery was developed according to the patient's preoperative risk factors and preoperative pulmonary function. 512 patients who entered the airway management process from March 2019 to May 2020 were included.

[Nasal manifestations of Sjogren's syndrome].

We reported a case of a 43-year-old female patient with nasal Sjogren's syndrome（SS）. She complained of dry and tingling nose for 5 months. Physical examination: bilateral nasal stenosis, swelling of the mucosa at the front of the nasal septum, dry oral mucosa, and strawberry tongue.

[Clinical treatment experience of perioperative nasal endoscopic surgery in patients with cardiovascular disease].

To investigate the perioperative management of endoscopic nasal surgery in patients with cardiovascular disease. Sixty-two patients with cardiovascular disease underwent endoscopic sinus surgery. Individualized medical treatment was used according to the patient's perioperative condition, followed by functional endoscopic surgery.

Insulinoma-associated protein 1 controls nasopharyngeal carcinoma to radiotherapy by modulating cyclin D1-dependent DNA repair machinery.

Insulinoma-associated protein 1 (INSM1), a zinc finger transcriptional factor, is proven to be deregulated in several types of cancers. However, comprehension of the molecular mechanism of INSM1-mediated tumor progression remains poor. Here, we show that the radioresistant nasopharyngeal carcinoma (NPC) patients have higher expressions of INSM1 that correlated with poor prognosis.

[The expression and role of MIF, NF-κB and IL-1β in nasal polyps].

Objective: To investigate the expression of MIF, NF-κB p65 and IL-1β in the tissue of nasal polyps and normal inferior turbinate, to analyze their relevance, and to explore their role in nasal polyps.

Method: The infiltrating results of EOS and others inflammatory cells in 48 cases diagnosed as nasal polyps (nasal polyps group) were detected by HE staining, and the expression of MIF, NF-κB p65 and IL-1β were investigated by immunohistochemistry. Twenty-one patients who were performed septoplasty orthotics were included as the control group; the VAS and Lund-Kennedy score were used to evaluate the degree of nasal polyps in patients and the correlation analysis was conducted between the disease severity and the expression levels of this three factors.

[The perioperative observation under endoscopic sinus surgery with asthma].

Objective: Aimed to discuss the perioperative treatment of the patient with asthma under endoscopic sinus surgery, to reduce the complications, adverse events and improve cure rate.

Method: One hundred and fifty-two patients with asthma under nasal endoscopic surgery were analyzed retrospectively.

Result: After specification of perioperative treatment, all patients with good control of asthma were in good condition before surgery.

[A case of giant cavernous hemangioma of the nasal septum].

To report a case of an adult male with a huge cavernous hemangioma arising from the nasal septum, and the lesion was widely spread to hard palate, sphenoid sinus, ethmoid sinus and right maxillary sinus. After giving embolization, it was completely excised via transnasal endoscopic approach and lateral rhinotomy, histologic examination reported cavernous hemangioma. There was no recurrence at 1 year's follow-up.

[Expression and correlational research of mTOR and 4EBP1 in laryngeal carcinoma].

Objective: This study aimed to explore the expression and their correlation of mammalian target of rapamycin (mTOR) and EIF4E binding protein1 (4EBP1) in laryngeal squamous cell carcinoma (LSCC).

Method: MTOR and 4EBP1 expression was studied using immunohistochemical methods in LSCC tissues of 77 cases and adjacent tissues of 18 cases,and then the relationship of their expression and clinical pathological factors were analyzed.

Result: The positive expression rates of mTOR and 4EBP1 were 54.

[Isolated sphenoid sinus disease: a clinical analysis of 159 cases].

Objective: Aimed to observe and analyse the diagnostic and therapeutic methods of the isolated sphenoid sinus disease, achieve earlier diagnosis and timelier intervention for this easily neglected disease and decrease the occurrence of misdiagnoses.

Method: A retrospective study was conducted in 159 patients with isolated sphenoid sinus disease.

Result: Headache was the most common presenting symptom (79.

[Inflammatory myofibroblastic tumor in the maxillary sinus: a case report and review of literature].

Objective: To investigate the clinical feature, diagnostic and therapeutic methods of inflammatory myofibroblastic tumor(IMT).

Method: One case of IMT was reported and the relevant literatures were reviewed.

Result: The computed tomography scan showed irregular soft tissue density shade and aggressive bone destruction with unclear boundary.

[Changes in DNA repair enzymes in rat ventroposterior nucleus of the thalamus after cerebral cortex infarction].

Objective: To investigate the damage within the ventroposterior nucleus (VPN) of the thalamus after focal cortical infarction and its mechanism, and explore the effect of ebselen on the oxidative damage after cerebral cortex infarction in hypertensive rats.

Methods: Middle cerebral artery occlusion (MCAO) was induced in stroke-prone renovascular hypertensive rats (RHRSP), and the rats were divided into four groups by table of random number: sham operation group, model group, vehicle group and ebselen group, each group consisted of 8 rats. In animals subjected to sham surgery the middle cerebral artery was exposed only.

[Expression of hypoxia inducible factor-1alpha and BNIP3 in human laryngeal carcinoma and their relationship].

Objective: To investigate the expression of Hypoxia inducible factor-1alpha (HIF-1alpha)and the Bcl-2/adenovirus E1B 19 kDa-interacting protein 3 (BNIP3) in human laryngeal carcinoma and their relationship.

Method: The expression of HIF-1ALPHA and BNIP3 were detected by SP immunohistochemical method in 45 cases with laryngeal carcinoma tissues and 12 adjacent normal laryngeal tissue.

Result: The expression of HIF-1alpha and BNIP3 were mainly in cytoplasm and nucleus.

[Distribution of basic fibroblast growth factor in inner ear of guinea pigs injected by different drug-approaches].

Objective: To investigate the approach of basic fibroblast growth factor(bFGF) entering inner ear, as well as its the protective mechanism to inner ear and nerve tissue in pathological situation.

Methods: 125I-bFGF was injected into guinea pigs body via the lateral ventricle and muscle under physical situation as well as pathological situation. Then the per minute gamma-radioactive in blood, liver, thyroid gland, brain, cochlear and perilymph fluid was counted, and the distribution and metabolism of bFGF in the inner ear and autoradiography of the cochlea were also observed.