Efficacy and safety of SHR8554 on postoperative pain in subjects with moderate to severe acute pain following orthopedic surgery: A multicenter, randomized, double-blind, dose-explored, active-controlled, phase II/III clinical trial.

Biased µ-opioid receptor (MOR) agonists enhance pain relief by selectively activating G protein-coupled receptor signaling and minimizing β-arrestin-2 activation, resulting in fewer side effects. This multicenter Phase II/III trial evaluated the optimal dosage, efficacy, and safety of SHR8554, a biased MOR agonist, for postoperative pain management following orthopedic surgery. In Phase II, 121 patients were divided into four groups to receive varying patient-controlled analgesia (PCA) doses of SHR8554 or morphine.

The genus Fraxinus L. (Oleaceae): A review of botany, traditional and modern applications, phytochemistry, and bioactivity.

Fraxinus L., a member of the Oleaceae family with approximately 60 species worldwide, is widely distributed in the warm temperate zone of the northern hemisphere. It is not only used as a folk medicine for treating various illnesses but is also documented in medical books.

Prognostic and Immunologic Significance of SH2B2 in Colon Adenocarcinoma and its Relationship to Proliferation, Migration, and Invasion.

Background: SH2B adaptor protein 2 (SH2B2, also named APS) is an adaptor protein implicated in the modulation of insulin signaling pathways and glucose metabolism. Its role in colon adenocarcinoma (COAD) is unknown.

Methods: Data from The Cancer Genome Atlas and Gene Expression Omnibus database were utilized to assess SH2B2 expression and its clinical significance in COAD.

The deacetylase SIRT6 reduces amyloid pathology and supports cognition in mice by reducing the stability of APP in neurons.

Alzheimer's disease (AD) is an aging-related neurodegenerative disorder that results in progressively impaired memory and is often associated with amyloid plaques. Previous studies implicate the deacetylases SIRT1 and SIRT2 in regulating the processing of amyloid precursor protein (APP). Here, we investigated whether APP is regulated by the related deacetylase SIRT6, which shows aging-associated decreases in activity.

Genetic profile in primary tumor tissue of advanced lung adenocarcinoma patients with adrenal metastasis.

The aim of this study was to examine the genomic characteristics and explore the molecular mechanisms underlying adrenal metastases in lung adenocarcinoma. 57 patients diagnosed with lung adenocarcinoma (LUAD) and adrenal metastases (AM) were enrolled, alongside 33 controls diagnosed with non-adrenal metastases (non-AM) at the time of diagnosis. The primary lung cancer tissue sample were analyzed using next-generation sequencing.

Exploring plant-microbe interactions in adapting to abiotic stress under climate change: a review.

Climatic change and extreme weather events have become a major threat to global agricultural productivity. Plants coexist with microorganisms, which play a significant role in influencing their growth and functional traits. The rhizosphere serves as an ecological niche encompassing plant roots and is a chemically complex environment that supports the growth and development of diverse plant-interactive microbes.

Thermoresponsive Phase Change Oleogel Microcapsules for Coencapsulation of Hydrophilic and Hydrophobic Actives.

To address the concurrent needs of the personal care industry for simultaneous protection of active ingredients and enhancement of product functionality, this study employs a microfluidic technique to fabricate EstoGel M-based oleogel microcapsules capable of coencapsulating both hydrophilic and hydrophobic actives. The oleogels exhibit gel-like characteristics with a melting point of approximately 70 °C, ensuring high encapsulation efficiency for hydrophilic and hydrophobic actives within aqueous environments. The oleogel microspheres encapsulating hydrophobic actives are prepared using microfluidic technology with robust elasticity, which can be ruptured by a force of less than 15 mN, contributing to a favorable tactile sensation upon application.

Melatonin reprograms soil microbial community, creates friendly soil environments, and promotes peanut growth.

Melatonin helps to regulate various physiological processes in plants, including growth, seed germination, and stress responses. However, the mechanism of how melatonin treatments affect soil microbe diversity and ecology, and plant growth needs to be better understood. Here, we report that melatonin coordinates interactions between soil microorganisms and root exudates to create a friendly soil environment for peanut growth under a controlled environment.

Towards generalizable face forgery detection via mitigating spurious correlation.

The continuous advancement of face forgery techniques has caused a series of trust crises, posing a significant menace to information security and personal privacy. In response, deep learning is being employed to develop effective detection methods to identify deepfake images and videos. Currently, most detection methods generally achieve satisfactory performance in intra-domain detection.

Enhancing sleep and mood in depressed adolescents: A randomized trial on nurse-led digital cognitive behavioral therapy for insomnia.

Background: Despite the effectiveness of digital cognitive behavior therapy for insomnia (dCBT-I) in treating comorbid insomnia and depression, its accessibility and high dropout rates among adolescents and young adults remain significant limitations. A potential solution could be nurse-led dCBT-I. This study evaluates the feasibility and efficacy of nurse-led dCBT-I in reducing insomnia symptoms and improving mood in adolescents and young adults with depression.

Movable surface acoustic wave tweezers: a versatile toolbox for micromanipulation.

Surface acoustic wave (SAW) tweezers are a promising multifunctional micromanipulation method that controls microscale targets via patterned acoustic fields. Owing to their device structure and bonding process, most SAW tweezers have limitations in terms of controlling the position and motion of the acoustic traps, as they generate an acoustic field with a fixed region and adjust the manipulation effects via signal modulation. To address this challenge, we propose movable SAW tweezers with a multilayer structure, achieving dynamic control of their wave field and acoustic trap positions; we demonstrate their precise manipulation functions, such as translation, in-plane rotation, out-of-plane rotation, and cluster formation, on a wide spectrum of samples, including particles, bubbles, droplets, cells, and microorganisms.

Mobility, Bioavailability, and Enrichment of Soil-Bound Phosphorus in Flood-Prone Paddy Fields: A Case Study of Kunnukara, South India.

Bioavailability, enrichment, and risk of phosphorus (P) and its fraction composition were monitored in the paddy soils of Kunnukara during the pre-cultivation and post-harvest periods in the years 2020 and 2021. Iron-bound P (≥ 105.56 ± 0.

3D Network Spacer-Embedded Flexible Iontronic Pressure Sensor Array with High Sensitivity over a Broad Sensing Range.

Microstructure construction is a common strategy for enhancing the sensitivity of flexible pressure sensors, but it typically requires complex manufacturing techniques. In this study, we develop a flexible iontronic pressure sensor (FIPS) by embedding an isolated three-dimensional network spacer (3DNS) between an ionic gel and a flexible TiCT MXene electrode, thereby avoiding complex microstructure construction techniques. By leveraging substantial deformation of the 3DNS and the high capacitance density resulting from the electrical double layer effect, the sensor exhibits high sensitivity (87.

Therapeutic potential of ADSCs in diabetic wounds: a proteomics-based approach.

Background: Diabetes mellitus (DM), a chronic metabolic disease characterized by elevated blood sugar, leads to delayed or non-healing wounds, increasing amputation risks, and placing a significant burden on patients and society. While extensive research has been conducted on adipose-derived stem cells (ADSCs) for promoting wound healing, there is a scarcity of studies focusing on diabetic wounds, particularly those employing proteomics and bioinformatics approaches.

Objective: This study aimed to investigate the mechanisms by which ADSCs promote diabetic wound healing using proteomics and bioinformatics techniques.

Spirulina platensis components mitigate bone density loss induced by simulated microgravity: A mechanistic insight.

In microgravity conditions, the consumption of Spirulina platensis (SP) as a renewable food source shows promise in mitigating osteoporosis due to its high nutritional content photosynthetic efficiency, environmental adaptability and positive effects on bone density, though the exact bioactive components and mechanisms remain unclear. Using a hindlimb suspension (HLS) model, this study investigated SP components: proteins (SPP), polysaccharides (SPS), lipids (SPL), and residue (SPR) on bone density and metabolism. Findings revealed that SPP and SPS significantly enhanced bone density and reduced oxidative stress.

Curdlan-Mediated Syngeneic RNAi against NF-κB in Glial Cells Protects Cerebral Vessels in the TBI Mouse Model.

Traumatic brain injury (TBI) activates the NF-κB pathway in microglia and astrocytes, which secrete pro-inflammatory cytokines that disrupt the blood-brain barrier (BBB). Curdlan derivatives are promising carriers for the delivery of siRNA drugs. Herein, we evaluated the glial cell specificity, siRNA delivery efficiency, and the subsequent phenotypic regulation of glial cells by the Curdlan derivatives in the TBI mouse model.

Multiple applications of metal-organic frameworks (MOFs) in the treatment of orthopedic diseases.

Pharmacologic treatment of orthopedic diseases is a common challenge for clinical orthopedic surgeons, and as an important step in the stepwise treatment of orthopedic diseases, it is often difficult to achieve satisfactory results with existing pharmacologic treatments. Therefore, it is increasingly important to find new ways to effectively improve the treatment pattern of orthopedic diseases as well as to enhance the therapeutic efficacy. It has been found that metal-organic frameworks (MOFs) possess the advantages of high specific surface area, high porosity, chemical stability, tunability of structure and biocompatibility.

New Utilization of Leaves: As a Safe and Promising Natural Antioxidant.

In this paper, an in-depth study on (FM) was conducted, focusing on the chemical constituents, in vitro and in vivo antioxidant activities of flavonoids, acute oral toxicity testing, network pharmacology, and molecular docking in the leaves of FM. The in vitro antioxidant results revealed that the total flavonoid extract (TFE), kaempferol, quercetin, and rutin exhibited similar antioxidant activities, with TFE demonstrating significantly better scavenging ability against hydroxyl radical compared to the other flavonoids. Moreover, in vivo antioxidant findings indicated that TFE led to a significant increase in glutathione peroxidase and superoxide dismutase activities along with a decrease in malondialdehyde levels in the liver tissues of mice in an ethanol-induced oxidative stress model, outperforming quercetin.