KSRP Deficiency Attenuates the Course of Pulmonary Aspergillosis and Is Associated with the Elevated Pathogen-Killing Activity of Innate Myeloid Immune Cells.

The mRNA-binding protein KSRP (KH-type splicing regulatory protein) is known to modulate immune cell functions post-transcriptionally, e.g., by reducing the mRNA stability of cytokines.

Trigeminal nerve hemangioblastoma in the setting of undiagnosed von Hippel-Lindau disease: illustrative case.

Background: Von Hippel-Lindau disease (VHL) is an autosomal dominant tumor predisposition syndrome caused by mutations in the VHL gene. Patients with VHL are predisposed to developing numerous neoplasms, including central nervous system hemangioblastomas that typically arise within the cerebellum, brainstem, or spinal cord. The authors present the unusual case of a 69-year-old patient with a hemangioblastoma of the trigeminal nerve as his initial presentation of VHL.

Individual peak alpha frequency does not index individual differences in inhibitory cognitive control.

Previous work has indicated that individual differences in cognitive performance can be predicted by characteristics of resting state oscillations, such as individual peak alpha frequency (IAF). Although IAF has previously been correlated with cognitive functions, such as memory, attention, or mental speed, its link to cognitive conflict processing remains unexplored. The current work investigated the relationship between IAF and inhibitory cognitive control in two well-established conflict tasks, Stroop and Navon task, while also controlling for alpha power, theta power, and the 1/f offset of aperiodic broadband activity.

Successful relief of central poststroke pain with BurstDR spinal cord stimulation: A case series.

Background: Central poststroke pain (CPSP) is a commonly undertreated condition that can negatively impact a patient's quality of life. The efficacy of spinal cord stimulation (SCS) for the treatment of CPSP is not established due to limited studies.

Case Description: Here, two patients, ages 42 and 75, sustained strokes resulting in CPSP.

The search for the relationship between female hormonal status, alpha oscillations, and aperiodic features of resting state EEG.

Fluctuations in sex steroid levels during the menstrual cycle and the use of hormonal contraceptives have been linked to changes in cognitive function and emotions in females. Such variations may be mediated by overall brain activity and excitability. We aimed to investigate the impact of female hormonal status on resting state EEG (rsEEG) parameters, including periodic (individual alpha frequency, alpha power) and aperiodic (1/f slope) features.

Contralateral delay activity and alpha lateralization reflect retinotopic and screen-centered reference frames in visual memory.

The visual system represents objects in a lateralized manner, with contralateral cortical hemispheres responsible for left and right visual hemifields. This organization extends to visual short-term memory (VSTM), as evidenced by electrophysiological indices of VSTM maintenance: contralateral delay activity (CDA) and alpha-band lateralization. However, it remains unclear if VSTM represents object locations in gaze-centered (retinotopic) or screen-centered (spatiotopic) coordinates, especially after eye movements.

Terms of debate: Consensus definitions to guide the scientific discourse on visual distraction.

Hypothesis-driven research rests on clearly articulated scientific theories. The building blocks for communicating these theories are scientific terms. Obviously, communication - and thus, scientific progress - is hampered if the meaning of these terms varies idiosyncratically across (sub)fields and even across individual researchers within the same subfield.

Transposable elements contribute to the establishment of the glycine shuttle in Brassicaceae species.

C -C intermediate photosynthesis has evolved at least five times convergently in the Brassicaceae, despite this family lacking bona fide C species. The establishment of this carbon concentrating mechanism is known to require a complex suite of ultrastructural modifications, as well as changes in spatial expression patterns, which are both thought to be underpinned by a reconfiguration of existing gene-regulatory networks. However, to date, the mechanisms which underpin the reconfiguration of these gene networks are largely unknown.

Alpha-Band Lateralization and Microsaccades Elicited by Exogenous Cues Do Not Track Attentional Orienting.

We explore the world by constantly shifting our focus of attention toward salient stimuli and then disengaging from them in search of new ones. The alpha rhythm (8-13 Hz) has been suggested as a pivotal neural substrate of these attentional shifts, due to its local synchronization and desynchronization that suppress irrelevant cortical areas and facilitate relevant areas, a phenomenon called alpha lateralization. Whether alpha lateralization tracks the focus of attention from orienting toward a salient stimulus to disengaging from it is still an open question.

EEGManyPipelines: A Large-scale, Grassroots Multi-analyst Study of Electroencephalography Analysis Practices in the Wild.

The ongoing reproducibility crisis in psychology and cognitive neuroscience has sparked increasing calls to re-evaluate and reshape scientific culture and practices. Heeding those calls, we have recently launched the EEGManyPipelines project as a means to assess the robustness of EEG research in naturalistic conditions and experiment with an alternative model of conducting scientific research. One hundred sixty-eight analyst teams, encompassing 396 individual researchers from 37 countries, independently analyzed the same unpublished, representative EEG data set to test the same set of predefined hypotheses and then provided their analysis pipelines and reported outcomes.

Learning-Induced Plasticity Enhances the Capacity of Visual Working Memory.

Visual working memory (VWM) is limited in capacity, though memorizing meaningful objects may refine this limitation. However, meaningful and meaningless stimuli typically differ perceptually, and objects' associations with meaning are usually already established outside the laboratory, potentially confounding experimental findings. Here, in two experiments with young adults ( = 45 and = 20), we controlled for these influences by having observers actively learn associations of (for them) initially meaningless stimuli: Chinese characters, half of which were consistently paired with pictures of animals or everyday objects in a learning phase.

The Utility of the 5 Factor Modified Frailty Index in Outcome Prediction for Patients with Chronic Subdural Hematoma Treated with Surgical Drainage.

Objective: Increasing frailty is a significant determinant of perioperative morbidity and mortality within neurosurgical literature. This study investigates the predictive value of the modified frailty index 5 (mFI-5) for postoperative morbidity and mortality following surgical drainage of chronic subdural hematoma (cSDH).

Methods: A retrospective cohort study was performed on patients who underwent surgical evacuation of a cSDH.

No evidence for rhythmic sampling in inhibition of return.

When exogenously cued, attention reflexively reorients towards the cued position. After a brief dwelling time, attention is released and then persistently inhibited from returning to this position for up to three seconds, a phenomenon coined 'inhibition of return' (IOR). This inhibitory interpretation has shaped our understanding of the spatio-temporal dynamics of the attentional spotlight after an exogenous visual cue for more than three decades.

Covid-19 affects taste independent of taste-smell confusions: results from a combined chemosensory home test and online survey from a large global cohort.

People often confuse smell loss with taste loss, so it is unclear how much gustatory function is reduced in patients self-reporting taste loss. Our pre-registered cross-sectional study design included an online survey in 12 languages with instructions for self-administering chemosensory tests with 10 household items. Between June 2020 and March 2021, 10,953 individuals participated.

Contralateral delay activity, but not alpha lateralization, indexes prioritization of information for working memory storage.

Working memory is inherently limited, which makes it important to select and maintain only task-relevant information and to protect it from distraction. Previous research has suggested the contralateral delay activity (CDA) and lateralized alpha oscillations as neural candidates for such a prioritization process. While most of this work focused on distraction during encoding, we examined the effect of external distraction presented during memory maintenance.

Covid-19 affects taste independently of smell: results from a combined chemosensory home test and online survey from a global cohort (N=10,953).

People often confuse smell loss with taste loss, so it is unclear how much gustatory function is reduced in patients self-reporting taste loss. Our pre-registered cross-sectional study design included an online survey in 12 languages with instructions for self-administering chemosensory tests with ten household items. Between June 2020 and March 2021, 10,953 individuals participated.

Fearful faces straight ahead or in the periphery: Early neuronal responses independently of trait anxiety.

For humans, it is vitally important to rapidly detect potentially threatening stimuli such as fearful faces in the periphery. Trait anxiety has been related to biased responses to threatening faces, which might be more pronounced for peripheral stimuli. We examined the impact of spatial location and trait anxiety on event-related potentials to fearful faces (ERPs) in a large sample ( = 80).

Early neural potentiation to centrally and peripherally presented fear-conditioned faces.

For humans, it is vitally important to rapidly detect and process threatening signals regardless of whether stimuli occur at fixation or in the periphery. However, it is unknown whether eccentricity affects early neuronal electrophysiological responses to fear-conditioned stimuli. We examined early event-related potentials (ERPs) of the electroencephalogram (EEG) to fear-conditioned faces to address this question.

The extent and specificity of visual exploration determines the formation of recollected memories in complex scenes.

Our visual memories of complex scenes often appear as robust, detailed records of the past. Several studies have demonstrated that active exploration with eye movements improves recognition memory for scenes, but it is unclear whether this improvement is due to stronger feelings of familiarity or more detailed recollection. We related the extent and specificity of fixation patterns at encoding and retrieval to different recognition decisions in an incidental memory paradigm.

Pupillometry and electroencephalography in the digit span task.

This dataset consists of raw 64-channel EEG, cardiovascular (electrocardiography and photoplethysmography), and pupillometry data from 86 human participants recorded during 4 minutes of eyes-closed resting and during performance of a classic working memory task - digit span task with serial recall. The participants either memorized or just listened to sequences of 5, 9, or 13 digits presented auditorily every 2 seconds. The dataset can be used for (1) developing algorithms for cognitive load discrimination and detection of cognitive overload; (2) studying neural (event-related potentials and brain oscillations) and peripheral (electrocardiography, photoplethysmography, and pupillometry) physiological signals during encoding and maintenance of each sequentially presented memory item; (3) correlating cognitive load and individual differences in working memory to neural and peripheral physiology, and studying the relationship between the physiological signals; (4) integration of the physiological findings with the vast knowledge coming from behavioral studies of verbal working memory in simple span paradigms.