Experimental study of combined effect of solvents and noise.

Experimental studies of simultaneous exposure of the organism to chemical compounds and other unfavourable occupational and social factors are of great importance for the understanding of the mechanisms of combined effect and the detection of the dose-effect dependence. On a total number of 2000 made Wistar rats, 7 series of experiments were carried out in which the combined effect of solvents widely used in industry (acetone, carbon disulphide, trichloroethylene) and noise at varying levels (1-2, 10 Limchr for the solvents and 85, 95 dB A for noise) and duration of exposure (1 1/2-2 and 4 months) was studied. Biological effect was evaluated dynamically using a complex of indices reflecting the state of the principal systems of the organism--the nervous, cardiovascular, endocrine and immune systems.

[Pharmacokinetics of the antiviral preparation, bonafton].

The parameters of bonafton pharmacokinetics (absorption, distribution, excretion) have been studied in male Wistar rats at single enteral and intraperitoneal administration. With these routes of administration daily resorption amounts to 26 and 100%, respectively. Regardless administration routes 14C-bonafton distributes in a similar way in the internal organs and tissues and is excreted through the kidneys and gastrointestinal tract, the latter way of excretion being predominant.

[Blastomogenic action of combined total x-ray irradiation and the administration of 131I on young rats].

The combined irradiation of rats, aged 36--42 days (the thyroid uptake--6900 rad) would induce the development of neoplasms characteristic of each factor exposure. The incidence of thyroid tumors (75.0%) was close to that induced by a separate 131I exposure (72.

[Blastomogenic action of combined total external and local internal (131I) irradiation on adult rats].

In the combined irradiation (the total dose of the thyroid uptake--15000 rad) the total incidence of tumors was close to that in isolated X-irradiation, but their multiplicity was much higher. The incidence of thyroid tumors (16.6%) was close to that in iodine-131 administration (17.