Prognostic impact of circulating tumor DNA detection in portal and peripheral blood in resected pancreatic ductal adenocarcinoma patients.

In PDAC patients, ctDNA detection's prognostic significance needs validation especially in resected patients. This study investigated ctDNA kinetics in portal and peripheral blood before and after resection, and whether tissue mobilization during surgery influences ctDNA detection. In this single-center prospective cohort, portal and peripheral blood were drawn during pancreaticoduodenectomy before and after tissue mobilization, during 12 postoperative months and were associated with overall survival (OS), recurrence-free survival (RFS) and CA19-9 (secondary endpoints).

Albumin influences leucocyte FcRn expression in the early days of kidney transplantation.

FcRn, a receptor originally known for its involvement in IgG and albumin transcytosis and recycling, is also important in the establishment of the innate and adaptive immune response. Dysregulation of the immune response has been associated with variations in FcRn expression, as observed in cancer. Recently, a link between autophagy and FcRn expression has been demonstrated.

Curative surgical treatment of common bile duct stones: Retrospective cohort study.

Background: In the event of symptomatic common bile duct (CBD) stones with dilated CBD, one possible curative treatment option is stone extraction through choledocotomy associated with cholecystectomy. Endoscopic treatment is only reserved for residual stones at 6 weeks. The aim of this study was to evaluate the results from laparoscopic curative surgical treatment of CBD stones with dilated CBD.

Finding the Right Heavy Chains for Immunostimulatory Antibodies.

For twelve years, the oncology field has been revolutionized by antibodies targeting immune checkpoints. They must be considered as a heterogenous family of immunostimulatory antibodies displaying very different mechanisms of action, not only depending on the target or on the cells expressing it, but also on the IgG subclass or IgG variant that has been chosen. To dissect this complex landscape, the clinical experience has been confronted with a precise analysis of the heavy chain isotypes, referred as new Ge nomenclature.

"Ways in which the neonatal Fc-receptor is involved in autoimmunity".

Since the neonatal IgG Fc receptor (FcRn) was discovered, its role has evolved from immunoglobulin recycling and biodistribution to antigen presentation and immune complex routing, bringing it to the center of both humoral and cellular immune responses. FcRn is thus involved in the pathophysiology of immune-related diseases such as cancer, infection, and autoimmune disorders. This review focuses on the role of FcRn in autoimmunity, based on the available data from both animal models and human studies.

The specific metabolome profiling of patients infected by SARS-COV-2 supports the key role of tryptophan-nicotinamide pathway and cytosine metabolism.

The biological mechanisms involved in SARS-CoV-2 infection are only partially understood. Thus we explored the plasma metabolome of patients infected with SARS-CoV-2 to search for diagnostic and/or prognostic biomarkers and to improve the knowledge of metabolic disturbance in this infection. We analyzed the plasma metabolome of 55 patients infected with SARS-CoV-2 and 45 controls by LC-HRMS at the time of viral diagnosis (D0).

Radical cure of experimental babesiosis in immunodeficient mice using a combination of an endochin-like quinolone and atovaquone.

Human babesiosis is a tick-borne multisystem disease caused by Babesia species of the apicomplexan phylum. Most clinical cases and fatalities of babesiosis are caused by Babesia microti Current treatment for human babesiosis consists of two drug combinations, atovaquone + azithromycin or quinine + clindamycin. These treatments are associated with adverse side effects and a significant rate of drug failure.

Validation of a noninvasive tension-time index of inspiratory muscles.

The aim of this study was to validate a noninvasive tension-time index (TT) for all the inspiratory muscles estimated from the measurement of mouth occlusion pressure (P0.1), i.e.

[Value of the stool bacteriological test in Mycobacterium avium complex infections in AIDS].

Incidence of Mycobacterium avium complex (MAC) infection has increased in HIV infected patients. We report a retrospective study of 25 cases of MAC infection occurring in HIV patients. Stools examination was performed in 5 (31%) of the patients without digestive symptoms and in the 9 (100%) patients presenting with diarrhoea.

Hb Poitiers [alpha 45(CE3)His-->Asp]: a new hemoglobin variant with a two-fold increase in oxygen affinity.

Hb Poitiers or alpha 45(CE3)His-->Asp was found in a 9-year-old French Caucasian boy. The structural modification concerns a heme contact and is responsible for an increased oxygen affinity and a faster than normal rate of autooxidation.

Bovine serum albumin immunization: a new risk of allergy during protocols for in vitro fertilization.

Three patients having undergone protocols for in vitro fertilization (IVF) showed an allergic reaction suggesting seric disease 6 to 10 days after follicle aspiration. The responsibility of bovine serum albumin, present in the follicle-rinsing fluid and in the medium used for embryo culture was suspected. An immunological study was carried out, using two groups for comparison.

[Health status of adolescents in the 7th grade at schools in Indre-et-Loire].

A survey of 1,316 pupils in the 7th grade in private or public schools in the department of Indre et Loire was conducted in order to establish the health status and needs of adolescents aged 12-15 years. Nutritional behavior, alcohol and tobacco consumption, obesity, hypertension, audio-visual disturbances, and dental status were the essential points of this survey. This study demonstrates the necessity of frequent and systematic health care supervision of adolescents, in an effort to detect and prevent or treat disturbances which may have long term adverse effects.

[Defense and illustration of a health examination in adolescents as observed in the course of secondary education].

In France, children's health is carefully looked after by periodical examinations from birth to six years old. But the french children cannot have afterwards a systematic health examination during the course of their compulsory attendance at school, except those preparing a technical teaching. The author suggests that an examination during the first period of adolescence (between 11 and 15 years old) should be a vector of information very useful to subjects themselves and knowledge in Public Health not much documented at this stage.

[Screening for craniomandibular dysfunction. Epidemiological survey concerning 891 healthy subjects].

The authors study the frequency of the TMJ disorders on healthy subjects. 891 subjects have been examined: 11.7% of the male population had at least two of the classic TMJ disorders signs, for 16.

[Cefotaxime in the treatment of purulent meningitis in children (author's transl)].

Five meningitis due to Haemophilus influenzae and 6 meningitis due to Enterobacteria were treated with cefotaxime. The antibiotic was administered at a dose of 150 to 200 mg/kg/day in four 1 hour infusions. The pathogens were eradicated in all patients.

[Dyskeratosis congenita Zinsser-Cole-Engman form. Report of two affected brothers (author's transl)].

Cutaneous pigmentation, lingual leukoplasia and dystrophic changes of nails are present in the two cases. The other clinical manifestations are dental alterations, epiphora, loss of dermal ridges of the pulp with hyperhidrosis, atrophic skin of the dorsum of the hands. Dysphagia and bone marrow hypoplasia are present in one case.

[Eradication of Candida from a premature infant unit].

To eradicate Candida from a neonatal unit the authors used increasingly strigent protocols of prophylaxis and treatment. Finally all carriers were identified and treated with nystatin. A strict routine for washing hands was introduced.