Publications by authors named "BORRELLI P"

Background: We aim to investigate the proportion of patients (pts) with long-term cognitive outcomes (CO) of PACC and identify associated features.

Methods: We assessed participants through a neuropsychological assessment. The chi-square test was used for comparisons according with time of NPA (within or beyond 6 months since COVID19) and with previously hospitalization status (hospitalized patients, PH; not hospitalized patients, nPH).

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  • In utero exposure to maternal conditions like obesity and Gestational Diabetes Mellitus (GDM) can negatively impact newborns through changes in DNA methylation patterns.
  • The study examined 101 Caucasian mother-infant pairs, finding that lower DNA methylation levels in newborns from GDM mothers were linked to lower birth weight and size.
  • Additionally, higher DNA methylation levels on the fetal side of the placenta were observed in obese mothers, correlating with increased maternal cholesterol levels, further influencing the metabolic health of the children.
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  • This study investigates the early diagnosis of preeclampsia (PE) by analyzing biochemical changes and immune system activity in pregnant women.
  • Researchers compared 30 women divided into three groups: healthy pregnant women, those with early preeclampsia, and those with late preeclampsia, focusing on various immune markers and lipid profiles.
  • Results showed notable increases in immune markers IL-6 and IL-8 in early preeclampsia cases, indicating heightened immune activity, while a decrease in PCSK9 gene expression was observed in early preeclampsia, suggesting potential implications for placental hormone synthesis.
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Numerous hydrological applications, such as soil erosion estimation, water resource management, and rain driven damage assessment, demand accurate and reliable rainfall erosivity data. However, the scarcity of gauge rainfall records and the inherent uncertainty in satellite and reanalysis-based rainfall datasets limit rainfall erosivity assessment globally. Here, we present a new global rainfall erosivity dataset (0.

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  • - This research presents a new method using deep learning and active learning to create accurate global maps of land susceptibility to wind erosion, employing models like RNN and GRU alongside various interpretation techniques.
  • - Thirteen environmental factors were analyzed, and through optimization, eight significant factors (such as wind speed and soil moisture) were selected to predict wind erosion risk.
  • - The findings show that the GRU-AL model was the most effective, categorizing global land into different levels of susceptibility, with significant insights into how factors like soil carbon and precipitation interact with erosion risk predictions.
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Problem: Knowledge about physical activity in pregnancy is limited compared to general population and several approaches have been used to evaluate duration and intensity of physical activity during pregnancy.

Background: Although physical activity can contribute to maternal and fetal well-being, more than half of women stopped their physical activity because of pregnancy.

Aim: To evaluate the adherence to physical activity of low-risk pregnant women by adapting an Italian version of the PPAQ.

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  • The study focused on the effectiveness of tixagevimab/cilgavimab (T/C) as pre-exposure prophylaxis (PrEP) in immunocompromised individuals, categorizing them into groups based on their COVID-19 history.
  • A total of 231 participants were included, with a significant portion having hematological diseases and receiving multiple vaccine doses; breakthrough infections (BTIs) occurred in 56 participants (24%) but were mostly mild to moderate.
  • Immune markers were measured over time, showing an initial increase in anti-RBD IgG antibodies at 3 months, a decline at 6 months, and low neutralizing antibodies, reinforcing T/C's clinical efficacy in reducing severe COVID-19
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Objectives: Evaluation of sarcopenia from computed tomography (CT) is often based on measuring skeletal muscle area on a single transverse slice. Automatic segmentation of muscle volume has a lower variance and may be a better proxy for the total muscle volume than single-slice areas. The aim of the study was to determine which abdominal and thoracic anatomical volumes were best at predicting the total muscle volume.

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  • The study aimed to analyze changes in hemodynamics (blood flow and heart function) during controlled ovarian stimulation in women undergoing in vitro fertilization at a hospital in Naples, Italy.
  • It included 68 infertile patients and assessed their cardiovascular parameters at three key time points: baseline, estradiol peak, and embryo transfer day.
  • The results indicated significant changes in cardiac output and stroke volume index at these time points, highlighting the impact of ovarian stimulation on maternal cardiovascular health, particularly in patients at risk of hyperstimulation.
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To minimize the toxicity and impact of combined antiretroviral therapy (cART) on the lifestyle of people living with Human Immunodeficiency Virus (PLWH), scientific community evaluated the efficacy, safety and sustained virologic response of two drugs antiretroviral regimens, in particular dolutegravir (DTG). The effects of deintensification therapy on inflammatory settings are currently unknown in PLWH. Thus, our study explored the inflammatory state in virologically suppressed HIV individuals between patients in treatment with a DTG-containing dual therapy (2DR) versus triple regimen therapies (3DR).

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Patients with multiple myeloma (MM) have an increased risk of sepsis due to underlying disease- and treatment-related immunosuppression. However, data on sepsis incidence, causative pathogens, and impact on outcomes in newly diagnosed MM (NDMM) are limited. We conducted a retrospective observational study of 92 NDMM patients who developed sepsis between 2022 and 2023 at a tertiary care center in Italy.

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Background: Multiple sclerosis (MS) is frequently accompanied by comorbid conditions.

Objectives: This study aimed to determine the prevalence of key comorbid conditions in people with multiple sclerosis (pwMS) and assess their impact on quality of life and work-related activities.

Methods: A cross-sectional study involving 755 pwMS from two third-level Italian MS centers was conducted.

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Challenges drive the state-of-the-art of automated medical image analysis. The quantity of public training data that they provide can limit the performance of their solutions. Public access to the training methodology for these solutions remains absent.

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  • COVID-19, caused by the SARS-CoV-2 virus, has led to millions of deaths and significant lifestyle changes, particularly impacting patients with sepsis in ICUs, where septic complications have a high mortality rate.
  • A clinical study was conducted at SS Annunziata Hospital in Italy, analyzing ICU patients diagnosed with sepsis from 2018 to 2021, dividing them into groups based on the pandemic and COVID-19 status.
  • Out of 1,559 ICU admissions, 211 patients met the sepsis criteria, revealing high mortality rates, especially amongst COVID-19 patients, with a notable relationship between mortality and scores on APACHE III and SOFA assessments.
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Land degradation is a complex socio-environmental threat, which generally occurs as multiple concurrent pathways that remain largely unexplored in Europe. Here we present an unprecedented analysis of land multi-degradation in 40 continental countries, using twelve dataset-based processes that were modelled as land degradation convergence and combination pathways in Europe's agricultural (and arable) environments. Using a Land Multi-degradation Index, we find that up to 27%, 35% and 22% of continental agricultural (~2 million km) and arable (~1.

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Obesity and overweight are common and complex conditions influenced by multiple genetic and environmental factors. Several genetic variants located in the genes involved in clock systems and fat taste perception can affect metabolic health. In particular, the polymorphisms in and genes were reported to be significantly related to cardiovascular disease, metabolic syndrome, sleep reduction, and evening preference.

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Modeling monthly rainfall erosivity is vital to the optimization of measures to control soil erosion. Rain gauge data combined with satellite observations can aid in enhancing rainfall erosivity estimations. Here, we presented a framework which utilized Geographically Weighted Regression approach to model global monthly rainfall erosivity.

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Deforestation reduces the capacity of the terrestrial biosphere to take up toxic pollutant mercury (Hg) and enhances the release of secondary Hg from soils. The consequences of deforestation for Hg cycling are not currently considered by anthropogenic emission inventories or specifically addressed under the global Minamata Convention on Mercury. Using global Hg modeling constrained by field observations, we estimate that net Hg fluxes to the atmosphere due to deforestation are 217 Mg year (95% confidence interval (CI): 134-1650 Mg year) for 2015, approximately 10% of global primary anthropogenic emissions.

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To validate the performance of automated Prostate Cancer Molecular Imaging Standardized Evaluation (aPROMISE) in quantifying total prostate disease burden with 18F-DCFPyL PET/CT and to evaluate the interobserver and histopathologic concordance in the establishment of dominant and index tumor. Patients with a recent diagnosis of intermediate/high-risk prostate cancer underwent 18F-DCFPyL-PET/CT for staging purpose. In positive-18F-DCFPyL-PET/CT scans, automated prostate tumor segmentation was performed using aPROMISE software and compared to an in-house semiautomatic-manual guided segmentation procedure.

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  • New EU policies post-2020 focus on soil conservation, influenced by the CAP 2023-2027, a proposed Soil Monitoring Law, and the 'A Soil Deal for Europe' mission.
  • Over 330 participants from 63 countries attended a 2022 EU Soil Observatory workshop on soil erosion, discussing key topics such as management practices and nutrient cycles.
  • The follow-up resulted in 15 manuscripts, with 9 selected for publication, highlighting challenges in soil erosion research amid the EU Green Deal's aims.
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Future phosphorus (P) shortages could seriously affect terrestrial productivity and food security. We investigated the changes in topsoil available P (AP) and total P (TP) in China's forests, grasslands, paddy fields, and upland croplands during the 1980s-2010s based on substantial repeated soil P measurements (63,220 samples in the 1980s, 2000s, and 2010s) and machine learning techniques. Between the 1980s and 2010s, total soil AP stock increased with a small but significant rate of 0.

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Background: In Italy the incidence of malignant mesothelioma (MM) among women is remarkably high, due to the several contexts in which women had been exposed to asbestos. However, very few studies in literature focus on the inorganic lung content in women. The aim of this retrospective, observational study is to investigate the asbestos lung burden, in terms of concentration, dimensions and type of asbestos, in 42 women who died from MM and had been non-occupationally exposed to asbestos during the activity of the asbestos-cement plant located in Broni (Pavia, Northern Italy) where mainly chrysotile, crocidolite and amosite were used.

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Numerous drivers such as farming practices, erosion, land-use change, and soil biogeochemical background, determine the global spatial distribution of phosphorus (P) in agricultural soils. Here, we revised an approach published earlier (called here GPASOIL-v0), in which several global datasets describing these drivers were combined with a process model for soil P dynamics to reconstruct the past and current distribution of P in cropland and grassland soils. The objective of the present update, called GPASOIL-v1, is to incorporate recent advances in process understanding about soil inorganic P dynamics, in datasets to describe the different drivers, and in regional soil P measurements for benchmarking.

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The present study aimed to investigate the consequence of resource competition between post-emotional processing and concurrent cognitive tasks. Previous studies have shown that such a resource competition engenders both short-term (e.g.

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Obesity and overweight represent a growing health problem worldwide. Genes regulating the intake and metabolism of different nutrients can positively or negatively influence the efficacy of nutritional interventions against obesity and its complications. The aim of this study was to assess changes in anthropometric and clinical parameters and the adherence to a Mediterranean diet (MedDiet) over time in relation to nutrigenetic variants in overweight or obese subjects affected by Type 2 Diabetes (T2D) or dysglycemia, who were included in a nutritional program.

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