Publications by authors named "BODDAERT J"
Background: Hip fracture is common and associated with high morbidity and mortality rates. Selective serotonin reuptake inhibitors (SSRIs) influence platelet hemostasis and might result in abnormal bleeding. This study aims to determine whether the use of SSRIs in older patients undergoing hip fracture surgery is associated with the risk of perioperative red blood cell (RBC) transfusion.
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- The study evaluated a new prehabilitation program for older adults scheduled for hip or knee replacement due to arthritis, focusing on its feasibility and participant satisfaction.
- Participants were adults aged 75 and older, receiving both hospital and home support that included nutritional, psychological, and physical health components.
- Results showed high participant engagement (89% completed the program), significant satisfaction ratings (60% rated it as "excellent" before surgery, increasing to 100% after), and a willingness to recommend it to others.
[Comparaison du déclin fonctionnel entre des patients atteints de démence à corps de Lewy et de la maladie d'Alzheimer].
Geriatr Psychol Neuropsychiatr Vieil
June 2024
Article Synopsis
- Lewy body dementia (LBD) is the second most common neurodegenerative disorder after Alzheimer's disease (AD) and this study focuses on comparing decline in functionality between LBD and AD patients over 18 months.
- The research involved 37 AD and 36 LBD patients aged over 70, all with a minimum MMSE score of 20, and found that LBD patients experienced a significant decline in Activities of Daily Living (ADL) compared to AD patients.
- Specifically, LBD patients showed a more rapid decrease in autonomy regarding personal care tasks such as bathing and dressing, highlighting a faster decline in their functional ability than that seen in AD patients.
Article Synopsis
- Hip fractures primarily impact older adults, leading to increased health complications and risks, prompting a review of non-steroidal anti-inflammatory drugs (NSAIDs) during their surgical recovery.
- The systematic review followed PRISMA guidelines, analyzing various studies on NSAIDs' effectiveness and safety in post-operative outcomes like pain control and complications after hip fracture surgery.
- Although some studies supported NSAIDs for pain management, findings on safety were inconsistent, indicating a need for more research to clarify the overall benefits and risks of using NSAIDs in these patients.*
Article Synopsis
- A study examined in-hospital mortality in older COVID-19 patients (aged ≥ 75) during the Omicron wave compared to previous waves from March 2020 to January 2022, using data from 38 hospitals in Greater Paris.
- Out of 195,084 hospitalized patients, 19,909 older patients were included, revealing an overall mortality rate of 22%, which dropped to 17% during the Omicron wave.
- Findings indicated that older patients faced significantly lower mortality and decreased risk of ICU admission during the Omicron wave (Wave 5) than during earlier waves (Waves 1-3).
Background: Immune checkpoints and their ligands are important actors of lymphocytes and monocytes activation's regulation. Their expression level within T cells changes with aging. Despite the major impact of aging on monocytes, there is no data about the expression of ICs on monocytes from old patients.
View Article and Find Full Text PDFFollowing acute stress such as trauma or sepsis, most of critically ill elderly patients become immunosuppressed and susceptible to secondary infections and enhanced mortality. We have developed a virus-based immunotherapy encoding human interleukin-7 (hIL-7) aiming at restoring both innate an adaptative immune homeostasis in these patients. We assessed the impact of this encoded hIL-7 on the immune functions of T cells from PBMC of immunosenescent patients with or without hip fracture.
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- The study aimed to evaluate geriatrics residents' self-confidence and skills in performing lumbar punctures (LP) and explored the benefits of using simulation and virtual reality for training.
- A survey found that an overwhelming majority of residents recognized the need for LP competency and supported additional practical training, while participants in simulated training praised its effectiveness.
- Results showed a significant improvement in residents' self-assessed skills after training, leading to an 85.8% success rate in actual clinical practice, highlighting the potential of simulation-based training for enhancing confidence and performance.
Article Synopsis
- - The study aims to identify modifiable factors linked to post-operative atrial fibrillation (POAF) in older patients (70+ years) undergoing hip fracture surgery, as limited data exists on this topic outside of cardiothoracic surgery.
- - Conducted as a nested case-control study in Paris, it involved 757 patients, with a matched analysis revealing an 8.5% incidence of POAF, predominantly affecting older, mostly female patients with significant comorbidities.
- - Key modifiable factors contributing to POAF included delays in surgery beyond 48 hours and the need for more than 2 units of packed red blood cells, emphasizing the importance of timely and effective perioperative care.
Introduction: Ventilator-associated pneumonia (VAP) caused by is a major cause of morbidity and mortality in hospital intensive care units (ICU). Rapid identification of -derived markers in easily accessible patients' samples can enable an early detection of VAP (VAP-PA), thereby stewarding antibiotic use and improving clinical outcomes.
Methods: Metabolites were analysed using liquid chromatography-mass spectrometry (LC-MS) in prospectively collected urine samples from mechanically ventilated patients admitted to the Antwerp University Hospital ICU.
Objectives: Vitamin D deficiency is common in patients undergoing hip fracture surgery (HFS) and has been found to be associated with poor post-operative outcome in other settings. This study aimed to analyze the association between vitamin D status and prognosis after HFS.
Design: Observational, prospective, single-center study.
Background: Few data are available on the prognosis of older patients who received corticosteroids for COVID-19. We aimed to compare the in-hospital mortality of geriatric patients hospitalized for COVID-19 who received corticosteroids or not.
Methods: We conducted a multicentric retrospective cohort study in 15 acute COVID-19 geriatric wards in the Paris area from March to April 2020 and November 2020 to May 2021.
Background: Advanced age is accompanied by a decline of immune functions, which may play a role in increased vulnerability to emerging pathogens and low efficacy of primary vaccinations in elderly people. The capacity to mount immune responses against new antigens is particularly affected in this population. However, its precise determinants are not fully understood.
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- Aging negatively impacts naive T cell function, leading to poorer immune responses to new antigens in elderly individuals.
- Research shows that elderly naive CD8 T cells are more likely to undergo cell death and struggle to proliferate when stimulated, linked to disrupted lipid metabolism and higher activation levels.
- Treatments that improve lipid metabolism, like rosiglitazone, can enhance the immune response of these T cells, suggesting potential strategies to improve vaccine effectiveness in older adults against cancers and respiratory viruses.
Article Synopsis
- Postoperative delirium (POD) is common in elderly surgical patients, leading to serious complications, longer recovery times, and higher healthcare costs; researchers believe melatonin might help prevent it due to its antioxidant and immune-boosting properties.
- The DELIRLESS trial will study the effects of melatonin versus a placebo on POD incidence in 718 patients aged 70+ undergoing surgery for lower limb fractures, comparing results based on validated delirium assessment scores.
- The trial has received ethical approval and aims to publish findings to contribute to medical knowledge on preventing POD in older patients.
Article Synopsis
- The study investigates the relationship between medication administered during the perioperative care of older patients (70+) who underwent hip fracture surgery and the incidence of postoperative delirium.
- Conducted in a Paris academic hospital, it included 490 patients, with a notable 44% experiencing delirium post-surgery.
- Key findings revealed that factors like advanced age, dementia, depression, and preoperative beta-blocker use were more strongly linked to delirium than the medications used during care.
Elevated Neopterin Levels Predict Fatal Outcome in SARS-CoV-2-Infected Patients.
Front Cell Infect Microbiol
September 2021
Article Synopsis
- Innate immune activation linked to Covid-19 infection can lead to severe clinical outcomes, particularly in older individuals and those with pre-existing health issues.* -
- The study measures neopterin levels in blood, finding that high levels in Covid-19 patients correlate with disease severity and outcomes, potentially serving as a useful biomarker.* -
- Specifically, neopterin levels above 19nM can differentiate Covid-19 patients from healthy individuals, while levels above 53nM indicate higher risks of mortality.*
Article Synopsis
- There is a strong connection between emergency departments and drug-related harm, highlighting the need for careful medication management.
- Healthcare providers should systematically assess the risk of iatrogenic accidents (medical mistakes) and evaluate new prescriptions to prevent such incidents during emergency visits.
- Precautionary measures are essential when a nurse is managing an emergency room, especially during the hospitalization of elderly patients.
Article Synopsis
- - The emergency department is the primary way older adults are admitted to hospitals, highlighting the complexity of managing their health care needs there.
- - Evaluating older patients presents unique challenges, making their emergency visits crucial events that may affect their overall health and functional abilities.
- - Promoting a geriatric-focused approach in emergency departments is vital, requiring strong collaboration between emergency physicians and geriatricians to provide tailored care for elderly patients.
HIV infection has become a chronic disease, with a lower mortality, but a consequent increase in age-related noninfectious comorbidities. Metabolic disorders have been linked to the effect of cART as well to the effects of immune activation and chronic inflammation. Whereas it is known that aging is intrinsically associated with hyperinflammation and immune system deterioration, the relative impact of chronic HIV infection on such inflammatory and immune activation has not yet been studied focusing on an elderly HIV-infected population.
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