The use of a standardized battery of Luria's tests in the diagnosis of lateralized cerebral dysfunction.

The present study was designed to examine the capability of a standardized battery of Luria's qualitative neuropsychological techniques in discriminating between right, left and diffuse brain-injured subjects. A total of sixty medically confirmed brain-damaged subjects were equally divided among the three groups. Subjects were assigned to two groups (right, left) according to medically proven lateralized brain injury to either the right or left hemisphere in the absence of verifiable insult to the opposite hemisphere.

[Clinical and laboratory aspects of malignant hyperthermia in children with special reference to creatine kinase isoenzymes (author's transl)].

The clinical and laboratory findings in 4 children with signs of malignant hyperthermia are reported. In all cases an extraordinary elevation of creatine kinase activity in serum was observed. By investigation of the creatine kinase isoenzyme activities we tried to determine the origin of creatine kinase.

[On drug metabolisation by mitochondria of rat liver (author's transl)].

Highly purified rat liver mitochondria, in spite of the permeability barrier of the mitochondrial membrane, are able to oxidise tertiary amines to amine oxides, to reduce N-oxides of tertiary amines and to oxidise substituted primary alcohols to the corresponding acids via instable aldehydes. This new information on the role of mitochondria in the metabolism of drugs was obtained with the aid of previous results on the biotransformation of the local anaesthetic fomocaine.

[A contribution to the identification of the oral antidiabetic agent tolbutamide. 1st communication].

An identification reaction for tolbutamide given in several pharmacopoeias involves the reaction of n-butylamine, formed by acid hydrolysis of tolbutamide, with diazotised p-nitroaniline to yield a characteristic red colour of unknown structure(s). It is demonstrated that, by using TLC methods, this red colour can be separated into 8 red or yellow coloured components. The structures of these isolated compounds were determined by spectroscopical methods and, in six cases, confirmed by unequivocal synthesis.