Antimicrobial FeO-CuO-PO glasses.

Glasses with high antimicrobial efficacy were developed in the FeO-CuO-PO ternary system to mitigate fomite-mediated transmission of infectious diseases in high-risk settings such as hospitals, daycares, and nursing homes. Binary CuO-PO glasses were not durable enough for use as high touch point articles, so FeO was added to the compositions to increase the chemical durability. The amount of Cu leachate decreased by at least 3 orders of magnitude when FeO was increased from 0 to 13.

Survival and glycemic control in patients with coexisting lymphoma and diabetes: a case-control analysis.

Aim: We examined the effect of diabetes on survival in patients with lymphoma and the effect of lymphoma on glycemic control.

Patients & Methods: Patients with lymphoma with and without diabetes (2005-2016) were retrospectively identified and matched 1:1. Overall survival and progression-free survival were estimated by the Kaplan-Meier method.

Chromosome-scale shotgun assembly using an in vitro method for long-range linkage.

Long-range and highly accurate de novo assembly from short-read data is one of the most pressing challenges in genomics. Recently, it has been shown that read pairs generated by proximity ligation of DNA in chromatin of living tissue can address this problem, dramatically increasing the scaffold contiguity of assemblies. Here, we describe a simpler approach ("Chicago") based on in vitro reconstituted chromatin.

Renal systems biology of patients with systemic inflammatory response syndrome.

A systems biology approach was used to comprehensively examine the impact of renal disease and hemodialysis (HD) on patient response during critical illness. To achieve this, we examined the metabolome, proteome, and transcriptome of 150 patients with critical illness, stratified by renal function. Quantification of plasma metabolites indicated greater change as renal function declined, with the greatest derangements in patients receiving chronic HD.

An integrated transcriptome and expressed variant analysis of sepsis survival and death.

Background: Sepsis, a leading cause of morbidity and mortality, is not a homogeneous disease but rather a syndrome encompassing many heterogeneous pathophysiologies. Patient factors including genetics predispose to poor outcomes, though current clinical characterizations fail to identify those at greatest risk of progression and mortality.

Methods: The Community Acquired Pneumonia and Sepsis Outcome Diagnostic study enrolled 1,152 subjects with suspected sepsis.

An integrated clinico-metabolomic model improves prediction of death in sepsis.

Sepsis is a common cause of death, but outcomes in individual patients are difficult to predict. Elucidating the molecular processes that differ between sepsis patients who survive and those who die may permit more appropriate treatments to be deployed. We examined the clinical features and the plasma metabolome and proteome of patients with and without community-acquired sepsis, upon their arrival at hospital emergency departments and 24 hours later.

Genome sequencing and mapping reveal loss of heterozygosity as a mechanism for rapid adaptation in the vegetable pathogen Phytophthora capsici.

The oomycete vegetable pathogen Phytophthora capsici has shown remarkable adaptation to fungicides and new hosts. Like other members of this destructive genus, P. capsici has an explosive epidemiology, rapidly producing massive numbers of asexual spores on infected hosts.

Fibrogenic and redox-related but not proinflammatory genes are upregulated in Lewis rat model of chronic silicosis.

Silicosis, a fibrotic granulomatous lung disease, may occur through accidental high-dose or occupational inhalation of silica, leading to acute/accelerated and chronic silicosis, respectively. While chronic silicosis has a long asymptomatic latency, lung inflammation and apoptosis are hallmarks of acute silicosis. In animal models, histiocytic granulomas develop within days after high-dose intratracheal (IT) silica instillation.

Impact of the duration of control of cattle lice with eprinomectin on leather quality.

The relationship between lice infestation in calves during their first winter and damage to the leather produced was investigated in a trial involving 500 calves, 100 of which were treated with a pour-on endectocide during the first winter. All the calves received routine lice treatment in the second winter and were reared to slaughter weight. The hides were removed at the abattoir, tanned, inspected for lice-related damage, and graded according to their suitability for the production of high quality leather.

Differences in younger, middle, and older children admitted to child psychiatric inpatient services.

Sociodemographic, family-environmental, clinical, and service use differences among younger (3-6 years), middle (7-10 years), and older (11-16 years) children admitted to a child psychiatric inpatient service were examined. Data was collected retrospectively on 327 children using a 152-item chart abstraction form from the children's medical charts in years 1993, 1995, 1996, and 1997. The results suggest that younger children compared to their older counterparts come from poorer functioning families and that family-environmental, rather than clinical, diagnostic variables differentiate these groups.

Sub-clinical parasitism in spring-born, beef suckler calves: epidemiology and impact on growth performance during the first grazing season.

Sub-clinical parasitism in spring-born single suckled beef calves was investigated from the middle of their first grazing season until weaning or housing later the same year. The study was conducted on four beef suckler herds in southern England over a 3-year period and involved a total of 334 spring-born beef suckler calves and their dams. The animals were grazed extensively on pastures naturally infected with nematode larvae.

Patterns of parasitic nematode infection and immunity in dairy heifers treated with ivermectin in a sustained-release bolus formulation either at turnout or in the middle of the grazing season.

Twenty-eight Holstein-Friesian heifers, born the previous year and weighing between 130 and 310 kg, were allocated to one of two treatment groups by restricted randomisation, based on their initial weight. The heifers in group 1 were each treated with ivermectin in a sustained-release bolus formulation at turnout in April, and those in group 2 were each given an ivermectin bolus on July 10, 84 days after turnout. On that day the mean geometric worm egg counts of groups 1 and 2 were 0.

Assisted venous drainage, venous air, and gaseous microemboli transmission into the arterial line: an in-vitro study.

The objective of this study was to examine the interaction of cardiopulmonary bypass venous air with assisted venous drainage, focusing on its production of gaseous microemboli in the arterial line. An in-vitro recirculating cardiopulmonary bypass circuit containing fresh whole bovine blood was monitored with a pulsed-doppler microbubble detector. Air of specific amounts was injected into the venous line and gaseous microemboli counts were obtained distal to the arterial filter.

The shortened advanced course for Army physicians.

The Army uses a series of career courses to prepare officers for progressive assignments. These courses have not been widely utilized by Army physicians. To improve the military education of physicians, an abbreviated Advanced Course was developed by the Academy of Health Science.

Surgical treatment of unruptured aneurysms of the posterior circulation.

With the ever-increasing number of intact aneurysms revealed by modern imaging, the options for their management are assuming great importance. While some knowledge has emerged as to their natural history and the results of surgical treatment of those in the anterior circulation, little information has been published concerning unruptured aneurysms arising from the posterior circulation. The authors report their experience since 1971 with 167 patients operated on for 179 unruptured vertebrobasilar aneurysms up to 25 mm in diameter.

Effects of injected deposteroid on posttonsillectomy morbidity: a double-blind study.

There are numerous studies using various agents to reduce posttonsillectomy morbidity. Due to lack of conclusive results a double-blind study using methylprednisolone acetate (Depo Medrol) was conducted. A total of 165 patients were randomly divided into two groups.