Publications by authors named "BERGQUIST S"

Introduction: Teaching kitchens are being used to facilitate lifestyle changes with a focus on culinary and nutrition programs to improve health behaviors. Less is known regarding their use as a worksite wellness program and their influence on employees' quality of life, body weight, and adoption of healthy behaviors. We evaluated changes in self-reported healthy behaviors, overall health, and weight during a one-year multidisciplinary teaching kitchen program.

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  • Mutations in the SETD2 gene are common in renal cell carcinoma (RCC), and a specific single nucleotide polymorphism (SNP), E902Q, was found in some RCC patients as an inherited or tumor-related mutation.
  • Researchers used CRISPR to create a similar mutation in the fruit fly gene Set2, discovering that it significantly lowered an important histone modification (H3K36me3) and led to problems with spindle formation during cell division.
  • The findings suggest that the SETD2 E902Q SNP not only influences histone methylation and spindle integrity but could also have important implications for understanding and treating RCC clinically.
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Objective: To measure changes in micronutrient adequacy and diet quality in healthcare and university employees who underwent a 10-week teaching kitchen program.

Methods: Thirty-eight healthcare and university employees participated in a 10-week teaching kitchen program. Twenty-seven completed self-administered, 24-hour dietary recalls to measure dietary intake at baseline and 3-months.

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Objective: To examine whether the financial burden of hospitalizations affects the health care utilization of household members of the admitted patient.

Data Sources: We utilized health care claims data from the Massachusetts All-Payer Claims Database, 2010-2015, to identify emergency hospitalizations of patients on family insurance plans and the health care utilization of the family members on those plans.

Study Design: We used an event-study analysis to compare health care spending and utilization of family members of a hospitalized individual and family members of an individual who was hospitalized 1 year later.

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  • - Chronic stress is linked to negative health effects and can accelerate biological aging, as measured by epigenetic clocks.
  • - This study investigates how chronic stress (measured by the Perceived Stress Scale) and resilience (assessed using the Connor-Davidson Resilience Scale) impact Grim Age acceleration among business executives.
  • - Results show that individuals with low stress and low resilience had the highest Grim Age acceleration, while those with high resilience experienced a complex interaction where high stress had a weaker impact on aging, indicating resilience may moderate the effects of stress on biological aging.
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The difficulty in identifying cancer stage in health care claims data has limited oncology quality of care and health outcomes research. We fit prediction algorithms for classifying lung cancer stage into three classes (stages I/II, stage III, and stage IV) using claims data, and then demonstrate a method for incorporating the classification uncertainty in survival estimation. Leveraging set-valued classification and split conformal inference, we show how a fixed algorithm developed in one cohort of data may be deployed in another, while rigorously accounting for uncertainty from the initial classification step.

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The Italian National Healthcare Service relies on per capita allocation for healthcare funds, despite having a highly detailed and wide range of data to potentially build a complex risk-adjustment formula. However, heterogeneity in data availability limits the development of a national model. This paper implements and ealuates machine learning (ML) and standard risk-adjustment models on different data scenarios that a Region or Country may face, to optimize information with the most predictive model.

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Introduction: Teaching kitchens have emerged as strategies to deliver lifestyle medicine principles and practices. However, a better understanding of their implementation, delivery cost, and potential benefits are needed. This article provides a comprehensive analysis of the costs associated with the development, deployment, and evaluation of the Emory Healthy Kitchen Collaborative (EHKC) teaching kitchen clinical trial.

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While much attention has been paid to healthcare provider and trainee burnout, less is known about provider well-being (i.e., flourishing) or about the effects of well-being on immune function.

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  • The study investigates the use of urine metabolomics for non-invasive staging of renal cell carcinoma (RCC), providing insights into the disease's progression through advanced analytical techniques.* -
  • Researchers employed liquid chromatography-mass spectrometry, nuclear magnetic resonance, and machine learning to classify RCC stages and estimate tumor size based on urine metabolites from 82 and 70 patients respectively.* -
  • Key findings included the successful prediction of tumor size and classification of RCC stages using machine learning models, with specific metabolites identified as potential markers for RCC progression.*
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  • The study explores the link between hair cortisol concentration (HCC) as a marker for chronic stress and the risk of coronary arterial disease (CAD) among 24 participants.
  • Results indicate that while HCC is significantly associated with CAD, its impact is weak compared to established risk factors like dyslipidemia and age.
  • Psychological and physiological resilience measures were considered, but they did not show a significant independent association with CAD, suggesting HCC's contribution to CAD risk is minimal in a typical population.
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Culinary-based self-care programs are innovative and increasingly utilized models for catalyzing behavior change and improving health and well-being. The content, duration, and delivery of existing programs vary considerably. Between January and August 2019, we developed a teaching kitchen and self-care curriculum, which was administered as part of a year-long worksite well-being program to employees at an academic healthcare system.

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  • - Renal cell carcinoma (RCC) is often diagnosed using costly imaging techniques and invasive biopsies, highlighting the need for a less invasive diagnostic method.
  • - Researchers used urine metabolomic profiling, employing liquid chromatography-mass spectrometry (LC-MS) and nuclear magnetic resonance (NMR), alongside machine learning to identify potential biomarkers for RCC.
  • - A seven-metabolite panel was developed, achieving 88% accuracy, 94% sensitivity, and 85% specificity in predicting RCC, demonstrating the potential of this noninvasive diagnostic approach.
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  • The study investigates the link between how often people travel for business and their health behaviors and body fat levels.
  • A retrospective analysis of 795 corporate health exam records reveals that more frequent travel is associated with higher body mass index and body fat, particularly in women.
  • The findings suggest that gender and the type of travel (domestic vs international) play significant roles in how business travel impacts body composition.
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We review 127 encounters for polymerase chain reaction-confirmed coronavirus disease 2019 (COVID-19) infection at a multidisciplinary outpatient clinic. We describe the symptomatology, time course, exam, and radiographic findings in this population. Patients with COVID-19 can experience persistent symptoms, primarily respiratory in nature, which can be severe enough to warrant hospitalization.

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Developmental screening instruments were designed as diagnostic tools, but there is growing interest in understanding whether select tools can also be used systematically in research to examine intervention impacts on long-term outcomes. As such, this systematic review aims to examine associations between child development assessment tools and educational attainment, academic achievement, or wealth. We included studies identified in PubMed, PsycINFO, and Educational Resources Information Center if they reported an association between at least one tool from a pre-established list and one outcome of interest after age 10.

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Objectives: The paper highlights US health policy and technology responses to the COVID-19 pandemic from January 1, 2020 - August 9, 2020.

Methods: A review of primary data sources in the US was conducted. The data were summarized to describe national and state-level trends in the spread of COVID-19 and in policy and technology solutions.

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The characteristics of patients with coronavirus disease 2019 (COVID-19) have primarily been described in hospitalized adults. Characterization of COVID-19 in ambulatory care is needed for a better understanding of its evolving epidemiology. Our aim is to provide a description of the demographics, comorbidities, clinical presentation, and social factors in confirmed SARS-CoV-2-positive non-hospitalized adults.

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Background: Cognitive abilities tend to decline in advanced age. A novel protective factor of cognitive decline in advanced age is purpose-in-life (PiL), a trait-like tendency to derive life meanings and purpose. However, whether PiL protects against cognitive decline in late-middle-age is unclear.

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Understanding the relationships between health and aging is essential for delaying morbidity and maximizing independence in aging populations as life expectancies increase. Loss of cognitive function is a feared age-associated condition and growing public health concern. Alzheimer's disease (AD), the most common cause of dementia, has no curative therapies.

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The conventional method for developing health care plan payment systems uses observed data to study alternative algorithms and set incentives for the health care system. In this paper, we take a different approach and transform the input data rather than the algorithm, so that the data used reflect the desired spending levels rather than the observed spending levels. We present a general economic model that incorporates the previously overlooked two-way relationship between health plan payment and insurer actions.

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Purpose: Cancer stage is a key determinant of outcomes; however, stage is not available in claims-based data sources used for real-world evaluations. We compare multiple methods for classifying lung cancer stage from claims data.

Methods: Our study used the linked SEER-Medicare data.

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Objective: To assess the issue of nonrepresentative sampling in Medicare Advantage (MA) risk adjustment.

Data Sources: Medicare enrollment and claims data from 2008 to 2011.

Data Extraction: Risk adjustment predictor variables were created from 2008 to 2010 Part A and B claims and the Medicare Beneficiary Summary File.

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Objective: To propose nonparametric ensemble machine learning for mental health and substance use disorders (MHSUD) spending risk adjustment formulas, including considering Clinical Classification Software (CCS) categories as diagnostic covariates over the commonly used Hierarchical Condition Category (HCC) system.

Data Sources: 2012-2013 Truven MarketScan database.

Study Design: We implement 21 algorithms to predict MHSUD spending, as well as a weighted combination of these algorithms called super learning.

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Research in oncology quality of care and health outcomes has been limited by the difficulty of identifying cancer stage in health care claims data. Using linked cancer registry and Medicare claims data, we develop a tool for classifying lung cancer patients receiving chemotherapy into early vs. late stage cancer by () deploying ensemble machine learning for prediction, () establishing a set of classification rules for the predicted probabilities, and () considering an augmented set of administrative claims data.

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