Evaluation of margins during radical prostatectomy: confocal microscopy vs frozen section analysis.

Objectives: To test the performance of ex vivo fluorescence confocal microscopy (FCM; Vivascope 2500M-G4), as compared to intra-operative frozen section (IFS) analysis, to evaluate surgical margins during robot-assisted radical prostatectomy (RARP), with final pathology as the reference standard.

Methods: Overall, 54 margins in 45 patients treated with RARP were analysed with: (1) ex vivo FCM; (2) IFS analysis; and (3) final pathology. FCM margins were evaluated by two different pathologists (experienced [M.

A Phase 3 Prospective Randomized Trial to Evaluate the Impact of Augmented Reality During Robot-assisted Radical Prostatectomy on the Rates of Postoperative Surgical Margins: A Clinical Trial Protocol.

We designed a phase 3, prospective, randomized trial to evaluate the impact of augmented reality and augmented reality frozen section analysis in reducing the rates of positive surgical margins after robot-assisted radical prostatectomy.

Artificial Intelligence-Based Hyper Accuracy Three-Dimensional (HA3D) Models in Surgical Planning of Challenging Robotic Nephron-Sparing Surgery: A Case Report and Snapshot of the State-of-the-Art with Possible Future Implications.

Recently, 3D models (3DM) gained popularity in urology, especially in nephron-sparing interventions (NSI). Up to now, the application of artificial intelligence (AI) techniques alone does not allow us to obtain a 3DM adequate to plan a robot-assisted partial nephrectomy (RAPN). Integration of AI with computer vision algorithms seems promising as it allows to speed up the process.

Health Information Technology Usability Evaluation Scale (Health-ITUES) and User-Experience Questionnaire (UEQ) for 3D Intraoperative Cognitive Navigation (ICON3D) System for Urological Procedures.

In recent years, the adoption of 3D models for surgical planning and intraoperative guidance has gained a wide diffusion. The aim of this study was to evaluate the surgeons' perception and usability of ICON3D platform for robotic and laparoscopic urological surgical procedures. During the 10th edition of the Techno-Urology Meeting, surgeons and attendees had the opportunity to test the new ICON3D platform.

Evidence Based Estimation of Macrodispersivity for Groundwater Transport Applications.

The scope of this work is to discuss the proper choice of macrodispersion coefficients in modeling contaminant transport through the advection dispersion equation (ADE). It is common to model solute concentrations in transport by groundwater with the aid of the ADE. Spreading is quantified by macrodispersivity coefficients, which are much larger than the laboratory observed pore-scale dispersivities.

Three-dimensional Augmented Reality-guided Robotic-assisted Kidney Transplantation: Breaking the Limit of Atheromatic Plaques.

Background: Robotic-assisted kidney transplantation (RAKT) has shown solid results as a minimally invasive alternative to the standard open approach (open kidney transplantation [OKT]). However, RAKT is still limited in those cases where the recipient's iliac vessels present atherosclerotic plaques, frequently found in elder patients and in those subjected to long-term hemodialysis. Unlike OKT, where the surgeon can palpate the arterial plaques, in minimally invasive surgery the haptic feedback is missing, making the vascular clamping and arteriotomy unsafe.

Predicting nitrous oxide emissions through riverine networks.

Nitrous oxide (NO) is currently the leading ozone-depleting gas and is also a potent greenhouse gas. Predictions of NO emissions from riverine systems are difficult and mostly accomplished via regression equations based on dissolved inorganic nitrogen (DIN) concentrations or fluxes, although recent studies have shown that hydromorphological characteristics can influence NO emissions in riverine reaches. Here, we propose a predictive model for NO riverine concentrations and emissions at the reach scale.

A catchment-scale model of river water quality by Machine Learning.

Water quality is a concern in most river basins worldwide due to the widespread release of pollutants which impacts the freshwater ecosystems. Exploring the relationships between drivers and water quality parameters at the regional scale is key in the identification of appropriate actions for the reduction of water pollution. Regional models are the appropriate tool to achieve this, though their development poses relevant challenges because of the complexity and non-linearity of such relationships.

On the delay between water temperature and invertebrate community response to warming climate.

We evaluated the effect of global warming on invertebrate communities at high altitudes using data from the Careser system. We procured data on air temperature, which was obtained over 50 years at altitudes above 2600 m a.s.

The BYPASS-CTCA Study: the value of Computed Tomography Cardiac Angiography (CTCA) in improving patient-related outcomes in patients with previous bypass operation undergoing invasive coronary angiography: Study Protocol of a Randomised Controlled Trial.

Background: Patients with ischaemic heart disease and previous coronary artery bypass grafting (CABG) often need coronary evaluation by means of invasive coronary angiography (ICA). ICA in such patients is technically more challenging and carries a higher risk of complications including kidney damage, myocardial infarction, stroke and death. Improvements in Computed Tomography Cardiac Angiography (CTCA) technology have ensured its emergence as a useful clinical tool in CABG assessment, allowing for its potential use in planning interventional procedures in this patient group.

A Comparison of Six Transport Models of the MADE-1 Experiment Implemented With Different Types of Hydraulic Data.

Six conceptually different transport models were applied to the macrodispersion experiment (MADE)-1 field tracer experiment as a first major attempt for model comparison. The objective was to show that complex mass distributions in heterogeneous aquifers can be predicted without calibration of transport parameters, solely making use of structural and flow data. The models differ in their conceptualization of the heterogeneous aquifer structure, computational complexity, and use of conductivity data obtained from various observation methods (direct push injection logging, DPIL, grain size analysis, pumping tests and flowmeter).

Technical aspects to maximize the hyperaccuracy three-dimensional (HA3D) computed tomography reconstruction for kidney stones surgery: a pilot study.

The aim of the current prospective pilot study was to describe a hyperaccuracy three-dimensional (HA3D) model reconstruction technique, specifically developed to maximize the visualization of the renal collecting system's anatomy, and its relationship with the stones, vessels and renal parenchyma, and to compare the HA3D virtual models with the intraoperative findings. The image acquisition was performed using a CT scanner (Toshiba, Aquilion Prime) and included the unenhanced, arterial, venous and excretory phases. The DICOM format CT images were processed by MEDICS Srl ( www.

NITRATE-CIN Study: Protocol of a Randomized (1:1) Single-Center, UK, Double-Blind Placebo-Controlled Trial Testing the Effect of Inorganic Nitrate on Contrast-Induced Nephropathy in Patients Undergoing Coronary Angiography for Acute Coronary Syndromes.

Background: Contrast-induced nephropathy (CIN), an acute kidney injury resulting from the administration of intravascular iodinated contrast media, is a significant cause of morbidity/mortality following coronary angiographic procedures in high-risk patients. Despite preventative measures intended to mitigate the risk of CIN, there remains a need for novel effective treatments. Evidence suggests that delivery of nitric oxide (NO) through chemical reduction of inorganic nitrate to NO may offer a novel therapeutic strategy to reduce CIN and thus preserve long term renal function.

Global riverine nitrous oxide emissions: The role of small streams and large rivers.

Nitrous oxide, NO, is the leading cause of stratospheric ozone depletion and one of the most potent greenhouse gases (GHG). Its concentration in the atmosphere has been rapidly increasing since the green revolution in the 1950s and 1960s. Riverine systems have been suggested to be an important source of NO, although their quantitative contribution has been estimated with poor precision, ranging between 32.

Priority and emerging organic microcontaminants in three Mediterranean river basins: Occurrence, spatial distribution, and identification of river basin specific pollutants.

There is a worldwide growing use of chemicals by our developed, industrialized, and technological society. More than 100,000 chemical substances are thus commonly used both by industry and households. Depending on the amount produced, physical-chemical properties, and mode of use, many of them may reach the environment and, notably, the aquatic receiving systems.

Power law scaling model predicts NO emissions along the Upper Mississippi River basin.

Nitrous oxide (NO) is widely recognized as one of the most important greenhouse gases, and responsible for stratospheric ozone destruction. A significant fraction of NO emissions to the atmosphere is from rivers. Reliable catchment-scale estimates of these emissions require both high-resolution field data and suitable models able to capture the main processes controlling nitrogen transformation within surface and subsurface riverine environments.

Three-dimensional Augmented Reality Robot-assisted Partial Nephrectomy in Case of Complex Tumours (PADUA ≥10): A New Intraoperative Tool Overcoming the Ultrasound Guidance.

Background: Despite technical improvements introduced with robotic surgery, management of complex tumours (PADUA score ≥10) is still a matter of debate within the field of transperitoneal robot-assisted partial nephrectomy (RAPN).

Objective: To evaluate the accuracy of our three-dimensional (3D) static and elastic augmented reality (AR) systems based on hyperaccuracy models (HA3D) in identifying tumours and intrarenal structures during transperitoneal RAPN (AR-RAPN), compared with standard ultrasound (US).

Design, Setting, And Participants: A retrospective study was conducted, including 91 patients who underwent RAPN for complex renal tumours, 48 with 3D AR guidance and 43 with 2D US guidance, from July 2017 to May 2019.

Evaluation of homogenization methods for seasonal snow depth data in the Austrian Alps, 1930-2010.

Despite the importance of snow in alpine regions, little attention has been given to the homogenization of snow depth time series. Snow depth time series are generally characterized by high spatial heterogeneity and low correlation among the time series, and the homogenization thereof is therefore challenging. In this work, we present a comparison between two homogenization methods for mean seasonal snow depth time series available for Austria: the standard normal homogeneity test (SNHT) and HOMOP.

New oral anti-coagulants versus vitamin K antagonists in high thromboembolic risk patients.

Background: Oral anticoagulant therapy (VKA) is nowadays the mainstay of treatment in primary and secondary stroke prevention in patients with atrial fibrillation. Given the limited risk-benefit ratio of vitamin K antagonists, pharmacological research has been directed towards the development of products that could overcome these limits, new oral anticoagulants were recently introduced: dabigatran, rivaroxaban, apixaban, and edoxaban.

Aim: Scope of the present study was to examine patterns of use, effectiveness, safety and mean annual cost per patient of anticoagulant treatment for non-valvular AF in real clinical practice.

Convenient use of electrical conductivity measurements to investigate hydrological processes in Alpine headwaters.

Developing effective hydrological models for streamflow generation in Alpine catchments is challenging due to the inherent complexity of the intertwined processes controlling water transfer from hillslopes to streams and along the river network. Over the past decades, studies have proposed complementing traditional hydrological information with environmental tracer data, e.g.

Impaired SIRT1 activity leads to diminution in glomerular endowment without accelerating age-associated GFR decline.

Glomerular filtration rate (GFR) declines with age such that the prevalence of chronic kidney disease is much higher in the elderly. SIRT1 is the leading member of the sirtuin family of NAD -dependent lysine deacetylases that mediate the health span extending properties of caloric restriction. Since reduction in energy intake has also been shown to decrease age-related kidney disease in rodents, we hypothesized that a diminution in SIRT1 activity would accelerate the GFR decline and structural injury with age.

A Critical Analysis of Transverse Dispersivity Field Data.

Transverse dispersion, or tracer spreading orthogonal to the mean flow direction, which is relevant e.g, for quantifying bio-degradation of contaminant plumes or mixing of reactive solutes, has been studied in the literature less than the longitudinal one. Inferring transverse dispersion coefficients from field experiments is a difficult and error-prone task, requiring a spatial resolution of solute plumes which is not easily achievable in applications.

Hydrogeophysical characterization and monitoring of the hyporheic and riparian zones: The Vermigliana Creek case study.

The hyporheic and riparian zones are critical domains in a river ecosystem since they mediate the interactions between surface water and groundwater. These domains are generally strongly heterogeneous and difficult to access; yet their characterization and monitoring still rely mostly on hard-to-perform invasive surveys that provide only point information. These well-known issues, however, can be overcome thanks to the application of minimally invasive methods.

Augmented-reality robot-assisted radical prostatectomy using hyper-accuracy three-dimensional reconstruction (HA3D™) technology: a radiological and pathological study.

Objectives: To assess the use of hyper-accuracy three-dimensional (HA3D™; MEDICS, Moncalieri, Turin, Italy) reconstruction based on multiparametric magnetic resonance imaging (mpMRI) and superimposed imaging during augmented-reality robot-assisted radical prostatectomy (AR-RARP).

Patients And Methods: Patients with prostate cancer (clinical stages cT1-3, cN0, cM0) undergoing RARP at our Centre, from June 2017 to April 2018, were enrolled. In all cases, cancer was diagnosed with targeted biopsy at the level of index lesion based on high-resolution (1-mm slices) mpMRI.

Particle bound pollutants in rivers: Results from suspended sediment sampling in Globaqua River Basins.

Transport of hydrophobic pollutants in rivers such as polycyclic aromatic hydrocarbons (PAHs), polychlorinated biphenyls (PCBs) and heavy metals is often facilitated by suspended sediment particles, which are typically mobilized during high discharge events. Suspended sediments thus represent a means of transport for particle related pollutants within river reaches and may represent a suitable proxy for average pollutant concentrations estimation in a river reach or catchment. In this study, multiple high discharge/turbidity events were sampled at high temporal resolution in the Globaqua River Basins Sava (Slovenia, Serbia), Adige (Italy), and Evrotas (Greece) and analysed for persistent organic pollutants such as PAHs (polycyclic aromatic hydrocarbons) or PCBs (polychlorinated biphenyls) and heavy metals.