Oxidative Stress and Cataract Formation: Evaluating the Efficacy of Antioxidant Therapies.

This comprehensive review investigates the pivotal role of reactive oxygen species (ROS) in cataract formation and evaluates the potential of antioxidant therapies in mitigating this ocular condition. By elucidating the mechanisms of oxidative stress, the article examines how ROS contribute to the deterioration of lens proteins and lipids, leading to the characteristic aggregation, cross-linking, and light scattering observed in cataracts. The review provides a thorough assessment of various antioxidant strategies aimed at preventing and managing cataracts, such as dietary antioxidants (i.

Cortical bone plate properties assessment using inversion of axially transmitted low frequency ultrasonic guided waves.

Over the past few decades, early osteoporosis detection using ultrasonic bone quality evaluation has gained prominence. Specifically, various studies focused on axial transmission using ultrasonic guided waves and have highlighted this technique's sensitivity to intrinsic properties of long cortical bones. This work aims to demonstrate the potential of low-frequency ultrasonic guided waves to infer the properties of the bone inside which they are propagating.

Automatic flaw detection in sectoral scans using machine learning.

Phased array ultrasonic testing (PAUT) requires highly trained and qualified personnel to interpret and analyze images. It takes a solid understanding of wave propagation physics to comprehend the generated images. As such, the inspector's judgment and level of experience have a significant impact on the analysis's outcome.

Transcatheter Edge-to-Edge Repair for Acute Papillary Muscle Rupture After Transvenous Lead Extraction in a d-TGA.

We present a case of a patient known for dextrotransposition of the great arteries corrected with a Mustard procedure, in whom severe mitral valve regurgitation secondary to transvenous lead extraction was successfully repaired with transcatheter edge-to-edge repair using the TriClip device (Abbott Vascular).

Surface breaking crack sizing method using pulse-echo Rayleigh waves.

Surface cracks are common in various industries. Eddy current testing (ECT) is commonly used for crack sizing but necessitates complex calibration standards and a highly trained inspector. Moreover, for large-area inspections, it requires additional scanning arrangements.

Exploring the Potential of Nanoporous Materials for Advancing Ophthalmic Treatments.

The landscape of ophthalmology is undergoing significant transformations, driven by technological advancements and innovations in materials science. One of the advancements in this evolution is the application of nanoporous materials, endowed with unique physicochemical properties ideal for a variety of ophthalmological applications. Characterized by their high surface area, tunable porosity, and functional versatility, these materials have the potential to improve drug delivery systems and ocular devices.

New sensitive LC-MS/MS method for the simultaneous determination of 13 phenolic and carboxylic acid pesticide biomarkers in human urine, including dicamba.

The commercialization in 2016 of genetically engineered seeds tolerant to dicamba and/or 2,4-dichlorophenoxyacetic acid (2,4-D) has caused a rapid increase in the use of these herbicides. New questions about the reproductive and chronic health effects of long-term exposure to these herbicides have been raised. To assess exposure to dicamba and other pesticides of interest in the Heartland Study, a birth cohort study based in the United States, a new analytical method was needed.

An alternative Rayleigh wave excitation method using an ultrasonic phased array.

Ultrasonic Rayleigh waves have been employed for in-service NDT inspection in a wide range of industries for years. The excitation of Rayleigh waves can be achieved using a variety of methods, with the so-called wedge technique being the most widely used. Recent years have seen considerable research interest in surface crack detection and sizing using Rayleigh waves excited and detected with the wedge technique.

Ultrasonic imaging using conditional generative adversarial networks.

The Full Matrix Capture (FMC) and Total Focusing Method (TFM) combination is often considered the gold standard in ultrasonic nondestructive testing, however it may be impractical due to the amount of time required to gather and process the FMC, particularly for high cadence inspections. This study proposes replacing conventional FMC acquisition and TFM processing with a single zero-degree plane wave (PW) insonification and a conditional Generative Adversarial Network (cGAN) trained to produce TFM-like images. Three models with different cGAN architectures and loss formulations were tested in different scenarios.

Ultrasonic Transducers for In-Service Inspection and Continuous Monitoring in High-Temperature Environments.

The inspection of structures operating at high temperatures is a major challenge in a variety of industries, including the energy and petrochemical industries. Operators are typically performing nondestructive evaluations using ultrasound to monitor component thicknesses during scheduled shutdowns, thereby ensuring safe operation of their plants. However, despite being costly, this calendar-based approach may lead to undetected corrosion, which can potentially result in catastrophic failures.

Compressive Sensing Strategy on Sparse Array to Accelerate Ultrasonic TFM Imaging.

Phased array ultrasonic testing (PAUT) based on full matrix capture (FMC) has recently been gaining popularity in the scientific and nondestructive testing communities. FMC is a versatile acquisition method that collects all the transmitter-receiver combinations from a given array. Furthermore, when postprocessing FMC data using the total focusing method (TFM), high-resolution images are achieved for defect characterization.

Implementation process evaluation of an ergonomic train the trainer program: How to learn from mechanisms and the temporal structure of processes?

In implementation process evaluation, the analysis of the temporal structure of processes is key for understanding the successive interactions between the flow of practitioners' actions and evolving workplace reactions and context. However, capturing the temporal structure of processes in data analysis is a methodological challenge, and available literature to overcome this challenge is scarce, especially for workplace ergonomic interventions. The aim of this paper was to perform an implementation process evaluation of an ergonomic train the trainer program taking into account the temporal structure of processes.

Biomonitoring of inorganic arsenic species in pregnancy.

Exposure assessment of inorganic arsenic is challenging due to the existence of multiple species, complexity of arsenic metabolism, and variety of exposure sources. Exposure assessment of arsenic during pregnancy is further complicated by the physiological changes that occur to support fetal growth. Given the well-established toxicity of inorganic arsenic at high concentrations, continued research into the potential health effects of low-level exposure on maternal and fetal health is necessary.

Characterization of the Elastic, Piezoelectric, and Dielectric Properties of Lithium Niobate from 25 °C to 900 °C Using Electrochemical Impedance Spectroscopy Resonance Method.

Lithium niobate (LiNbO3) is known for its high Curie temperature, making it an attractive candidate for high-temperature piezoelectric applications (>200 °C); however, the literature suffers from a paucity of reliable material properties data at high temperatures. This paper therefore provides a complete set of elastic and piezoelectric coefficients, as well as complex dielectric constants and the electrical conductivity, for congruent monocrystalline LiNbO3 from 25 °C to 900 °C at atmospheric pressure. An inverse approach using the electrochemical impedance spectroscopy (EIS) resonance method was used to determine the materials’ coefficients and constants.

Simulation-Based Inversion for the Characterization of Adhesively Bonded Joints Using Ultrasonic Guided Waves.

Adhesively bonded structures are widely used to facilitate the manufacturing process and enhance the performance of critical components in the aerospace, automotive, and energy industries. The assessment of the bond layer using the propagation of ultrasonic guided waves has been extensively investigated in the literature using several different approaches. In this study, a finite element (FE) model was used to simulate the dispersion curves of the modes propagating in an aluminum/adhesive/aluminum bonded structure.

An Improved Synthesis of Glucuronide Metabolites of Hindered Phenolic Xenoestrogens.

Aims And Objective: The syntheses of glucuronide metabolites of phenolic xenoestrogens triclosan and 2-phenylphenol, namely triclosan-O-glucuronide (TCS-G; 1), and 2-phenylphenol-Oglucuronide (OPP-G; 2), were achieved for use as analytical standards.

Methods: Under classical conditions previously reported for glucuronide synthesis, the final basic hydrolysis of the peracylated ester intermediate leading to the free glucuronides is often a limiting step. Indeed, the presence of contaminating by-products resulting from ester elimination has often been observed during this step.

Lightweight and Amplitude-Free Ultrasonic Imaging Using Single-Bit Digitization and Instantaneous Phase Coherence.

In the field of ultrasonic nondestructive testing (NDT), the total focusing method (TFM) and its derivatives are now commercially available on portable devices and are getting more popular within the NDT community. However, its implementation requires the collection of a very large amount of data with the full matrix capture (FMC) as the worst case scenario. Analyzing all the data also requires significant processing power, and consequently, there is an interest in: 1) reducing the required storage capacity used by imaging algorithms, such as delay-and-sum (DAS) imaging and 2) allowing the transmission and postprocessing of inspection data remotely.

Probe Standoff Optimization Method for Phased Array Ultrasonic TFM Imaging of Curved Parts.

The reliability of the ultrasonic phased array total focusing method (TFM) imaging of parts with curved geometries depends on many factors, one being the probe standoff. Strong artifacts and resolution loss are introduced by some surface profile and standoff combinations, making it impossible to identify defects. This paper, therefore, introduces a probe standoff optimization method (PSOM) to mitigate such effects.

Direct LC-MS/MS and indirect GC-MS/MS methods for measuring urinary bisphenol A concentrations are comparable.

Background: Bisphenol A (BPA) is typically measured in urine using an indirect method that involves enzymatic deconjugation and extraction. In contrast, the direct method measures free and conjugated BPA concurrently and sums them to estimate urinary BPA concentrations. Statistical comparison of total BPA results using the direct and indirect methods is necessary to accurately interpret biomonitoring data for risk assessments.

Ultrasonic assessment of osseointegration phenomena at the bone-implant interface using convolutional neural network.

Although endosseous implants are widely used in the clinic, failures still occur and their clinical performance depends on the quality of osseointegration phenomena at the bone-implant interface (BII), which are given by bone ingrowth around the BII. The difficulties in ensuring clinical reliability come from the complex nature of this interphase related to the implant surface roughness and the presence of a soft tissue layer (non-mineralized bone tissue) at the BII. The aim of the present study is to develop a method to assess the soft tissue thickness at the BII based on the analysis of its ultrasonic response using a simulation based-convolution neural network (CNN).

Towards using convolutional neural network to locate, identify and size defects in phased array ultrasonic testing.

Machine learning algorithms are widely used in image recognition. In Phased Array Ultrasonic Testing (PAUT), images are typically formed through constructive and destructive superpositions of signals backscattered from flaws or geometric features. However, all PAUT data acquisition schemes require several emissions and the duration of the acquisition may be too slow in high-speed manufacturing.

Determination of glyphosate, glufosinate and their major metabolites in urine by the UPLC-MS/MS method applicable to biomonitoring and epidemiological studies.

The preoccupation concerning glyphosate (GLYP) has rapidly grown over recent years, and the availability of genetically modified crops that are resistant to GLYP or glufosinate (GLUF) has increased the use of these herbicides. The debate surrounding the carcinogenicity of GLYP has raised interest and the desire to gain information on the level of exposure of the population. GLYP and aminomethylphosphonic acid (AMPA) are commonly simultaneously analysed.

Implementation of a systematic tobacco treatment protocol in a surgical outpatient setting: a feasibility study.

Background: Smoking cessation programs started as late as 4 weeks before surgery reduce perioperative morbidity and death, yet outpatient clinic interventions are rarely provided. Our aim was to evaluate the feasibility of implementing a tobacco treatment protocol designed for an outpatient surgical setting.

Methods: We completed a pre-post feasibility study of the implementation of a systematic, evidence-based tobacco treatment protocol in an outpatient colorectal surgery clinic.