Publications by authors named "BATES N"
Article Synopsis
- * Researchers used genetic screening to identify key genes that help these persister cells survive during both normal and stress-induced conditions, uncovering a role for detoxifying reactive oxygen species (ROS).
- * They discovered that antibiotic exposure generates ROS, which can worsen bacterial death, and identified that the enzyme KatG is critical for the survival of persister cells under certain conditions, particularly in nutrient-deprived environments.
Purpose: To report the rate of anterior cruciate ligament (ACL) graft failure by physis status (open, closing, closed) and to analyze which factors were associated with higher risk of ACL graft failure.
Methods: Patients younger than 18 years who underwent transphyseal ACL reconstruction (ACLR) between 2000 and 2018 at a single institution were reviewed at minimum 2 years after ACLR. Patient records were reviewed for anthropometrics, surgical techniques, and ACL graft failure.
Context: Epidemiological studies have shown an increased risk of musculoskeletal injury after concussion. The purpose of this study was to determine whether the reverse relationship exists, specifically whether there is an increased risk of concussion after an anterior cruciate ligament (ACL) injury in a population-based cohort.
Design: Retrospective cohort.
Article Synopsis
- The study aimed to evaluate shear wave elastography as a predictor for mechanical failure and injury risk in superficial knee ligaments, particularly the anterolateral and medial collateral ligaments.
- Researchers used 8 cadaver specimens to measure tissue stiffness with elastography and performed mechanical failure testing to gather data on load, displacement, and strain.
- Results showed a strong correlation between elastography stiffness and ligament strain at failure, but the method's reliability for predicting performance and assessing injury risk was limited.
Article Synopsis
- - The Navitor IDE study examines the safety and effectiveness of the Navitor valve for patients with severe aortic stenosis who are at high surgical risk, focusing on the connection between patient factors and the rate of new permanent pacemaker implantation (PPI) within 30 days post-surgery.
- - Researchers analyzed data from 260 patients, excluding those with prior pacemakers, and found that specific conduction abnormalities, like first-degree atrioventricular block and right bundle branch block, increased the likelihood of new PPI, while the depth of the valve implantation also played a significant role.
- - The study concludes that both existing conduction issues and the surgical technique (implant depth) are critical predictors of whether patients will need a new pacemaker
With a view to developing a much-needed non-invasive method for monitoring the healthy pluripotent state of human stem cells in culture, we undertook proteomic analysis of the waste medium from cultured embryonic (Man-13) and induced (Rebl.PAT) human pluripotent stem cells (hPSCs). Cells were grown in E8 medium to maintain pluripotency, and then transferred to FGF2 and TGFβ deficient E6 media for 48 hours to replicate an early, undirected dissolution of pluripotency.
View Article and Find Full Text PDFArticle Synopsis
- The study investigates HNF1B, a gene that encodes a transcription factor important for kidney development, and its mutations that lead to kidney malformations.
- Researchers created kidney organoids with HNF1B mutations using CRISPR-Cas9 technology to study the resulting abnormalities at a cellular level.
- Findings revealed that these mutant organoids had deformed tubules and altered gene expression affecting key pathways, contributing to a better understanding of how HNF1B mutations cause kidney disease.
Article Synopsis
- Bioactive glass synthetic bone grafts are increasingly used in orthopaedic surgery for treating severe bone injuries, but their clinical usage patterns are not well documented.
- This study aimed to analyze patient demographics, surgical details, and postoperative outcomes of fracture patients who received bioactive glass grafts compared to control groups.
- The results indicated significant differences in surgery length, costs, and vitamin D supplementation between patients using Fibergraft Matrix and Fibergraft Putty and their respective control groups, highlighting the influence of these bone graft materials on patient outcomes.
Background: Isoxazolines are rarely reported to be associated with neurological adverse events in cats and dogs, but information about the onset and duration of neurological signs is lacking in the summary of product characteristics of these medicines.
Methods: The Veterinary Poisons Information Service and the Dutch Poisons Information Center databases were searched using the Veterinary Dictionary for Drug-Related Affairs terms for ataxia, muscle tremor, convulsions or hyperesthesia in cats and dogs exposed to isoxazolines.
Results: There were 22 cases with and 57 cases without outcome information, mostly involving fluralaner or sarolaner.
Osteoarthritis is the most common degenerative joint condition, leading to articular cartilage (AC) degradation, chronic pain and immobility. The lack of appropriate therapies that provide tissue restoration combined with the limited lifespan of joint-replacement implants indicate the need for alternative AC regeneration strategies. Differentiation of human pluripotent stem cells (hPSCs) into AC progenitors may provide a long-term regenerative solution but is still limited due to the continued reliance upon growth factors to recapitulate developmental signalling processes.
View Article and Find Full Text PDFIntroduction: Military transport can induce whole-body vibrations, and combat almost always involves high impact between lower extremities and the ground. Therefore, robust splinting technology is necessary for lower extremity fractures in these settings. Our team compared a novel one-step spray-on foam splint (FastCast) to the current military standard structured aluminum malleable (SAM) splint.
View Article and Find Full Text PDFOxygen minimum zones (OMZs) are expanding due to increased sea surface temperatures, subsequent increased oxygen demand through respiration, reduced oxygen solubility, and thermal stratification driven in part by anthropogenic climate change. Devil's Hole, Bermuda is a model ecosystem to study OMZ microbial biogeochemistry because the formation and subsequent overturn of the suboxic zone occur annually. During thermally driven stratification, suboxic conditions develop, with organic matter and nutrients accumulating at depth.
View Article and Find Full Text PDFArticle Synopsis
- Anterior cruciate ligament (ACL) ruptures often coincide with injuries to the anterolateral ligament (ALL) and medial collateral ligament (MCL), with the ALL being injured more frequently despite having less resistance to knee movement.
- A study involving eight cadaver specimens measured strain and stiffness of the MCL and ALL using advanced mechanical testing methods, revealing differences in their material properties.
- The MCL showed greater strain and stiffness, while the ALL had higher failure stress; these distinctions likely explain the ALL’s higher injury rates when ACL injuries occur.
Optogenetics is a rapidly advancing technology combining photochemical, optical, and synthetic biology to control cellular behavior. Together, sensitive light-responsive optogenetic tools and human pluripotent stem cell differentiation models have the potential to fine-tune differentiation and unpick the processes by which cell specification and tissue patterning are controlled by morphogens. We used an optogenetic bone morphogenetic protein (BMP) signaling system (optoBMP) to drive chondrogenic differentiation of human embryonic stem cells (hESCs).
View Article and Find Full Text PDFArticle Synopsis
- - The study investigated how neuromuscular and proprioceptive training (NPT) affects knee health and overall wellness in active seniors, finding positive results.
- - Participants who engaged in 10 weeks of NPT showed significant improvements in mental health, reduced stress levels, and better sleep quality compared to a control group that received no intervention.
- - Results also indicated enhanced knee force and improvements in visual-motor skills and force steadiness specifically in the group that did the NPT, highlighting the program's effectiveness in promoting musculoskeletal health and well-being.
Introduction: Lateral ankle sprains are the most common type of injury to the ankle and can lead to ankle instability. There are many described techniques for the surgical treatment of lateral ankle instability. The purpose of this study is to quantify the variation in surgeon technique for lateral ankle instability treatment.
View Article and Find Full Text PDFBackground: Low back pain is a common cause of disability in the US with increasing financial burden on healthcare. A variety of treatment options exist to combat LBP. Home-based therapy is a low-cost option, but there is a lack of data on how it compares to therapy in clinical settings.
View Article and Find Full Text PDFPhysician Assistant Student Attitudes Toward Gamification of Cardiac Auscultation Instruction.
J Physician Assist Educ
December 2023
Introduction: Current physician assistant (PA) learners have a clear preference for interactive learning that is vibrantly present in new media technologies. At present, there is a paucity of research regarding use or acceptability of gamification in PA education. The purpose of this study was to examine PA students' experience with, attitudes toward, and outcomes of a gamified cardiac auscultation curriculum.
View Article and Find Full Text PDFBackground: The aim of this study was to assess the quality of effective discharge communication to primary practice from a hospital that uses ieMR (integrated electronic Medical Record), a complete electronic prescribing/medical record platform.
Methods: A retrospective quantitative analysis of 232 discharge encounters from a major tertiary hospital assessed the discharge summary quality; timeliness, completeness and medication information.
Results: Median time to discharge summary was 1day.
Article Synopsis
- After an ACL injury, some athletes have a hard time coming back to sports, and mental factors may be a big reason for this struggle.
- The study looked at how thigh muscle control and mental readiness relate for athletes who have had ACL injuries compared to healthy athletes.
- Results showed injured athletes had different muscle activity patterns and sizes in their thigh muscles, especially those who felt less ready to return to sports, which could help improve rehab programs in the future.
Transitions of patient care between hospital discharge and primary care are known to be an area of high-risk where communication is imperative for patient safety. Discharge summaries are known to often be incomplete, delayed and unhelpful for community healthcare providers. The aim of this review was to identify and map the literature which discusses Australian general practitioners' (GPs) views on the qualities that make up effective discharge communication.
View Article and Find Full Text PDF