Memory B Cells Provide Long-Term Protection to Vaccinated Kidney Transplant Recipients Against SARS-CoV-2 Variants.

Kidney transplant recipients (KTRs) are highly vulnerable to COVID-19. An intensified scheme of vaccination offers short-term protection to the 50%-75% of KTRs able to develop a germinal center reaction, required for the generation of neutralizing titers of antibodies (NAbs). However, the duration of this vaccinal protection is unknown.

Valid and accurate simple equation to predict 3,000-m steeplechase performance.

Introduction: Predict running performances is very important for athletes and trainers. Sport researchers have therefore developed certain tools to predict running performances, but only in non-obstacle races. This study aimed to develop and test the validity and accuracy of an equation for predicting 3,000-m steeplechase performance ( ).

[Hypercalcemia: a practical review].

Hypercalcemia, defined as an abnormal elevation of serum calcium, is a common electrolyte anomaly in primary care, affecting almost 1% of the worldwide population. Clinical manifestations concern the neuromuscular, cardiovascular, gastrointestinal, renal and skeletal systems. Among the causes, the main ones are primary hyperparathyroidism, and malignancies.

Mycobacterium tuberculosis genetic features associated with pulmonary tuberculosis severity.

Objectives: Mycobacterium tuberculosis (Mtb) infections result in a wide spectrum of clinical presentations but without proven Mtb genetic determinants. Herein, we hypothesized that the genetic features of Mtb clinical isolates, such as specific polymorphisms or microdiversity, may be linked to tuberculosis (TB) severity.

Methods: A total of 234 patients with pulmonary TB (including 193 drug-susceptible and 14 monoresistant cases diagnosed between 2017 and 2020 and 27 multidrug-resistant cases diagnosed between 2010 and 2020) were stratified according to TB disease severity, and Mtb genetic features were explored using whole genome sequencing, including heterologous single-nucleotide polymorphism (SNP), calling to explore microdiversity.

Relationships Between Sports Club Participation and Health Determinants in Adolescents and Young Adults.

Physical fitness is a powerful marker of health in adolescents and young adults. The purpose of this study was to measure the relationships between age, sex, body mass index, and sports club participation on physical fitness. The population included 49,988 participants (23,721 girls and 26,267 boys) who were divided into five age groups (11-12, 13-14, 15-16, 17-18, and 19-21 years).

Synthesis and Biological Evaluation of Benzo[]thiophene Acylhydrazones as Antimicrobial Agents against Multidrug-Resistant .

The benzo[]thiophene nucleus and the acylhydrazone functional group were combined to prepare three new series of compounds for screening against . The reaction of substituted benzo[]thiophene-2-carboxylic hydrazide and various aromatic or heteroaromatic aldehydes led to a collection of 26 final products with extensive structural diversification on the aromatic ring and on position 6 of the benzo[]thiophene nucleus. The screening lead to the identification of eight hits, including ()-6-chloro-'-(pyridin-2-ylmethylene)benzo[]thiophene-2-carbohydrazide (), a non-cytotoxic derivative showing a minimal inhibitory concentration of 4 µg/mL on three strains, among which were a reference classical strain and two clinically isolated strains resistant to methicillin and daptomycin, respectively.

Is Football or Badminton Associated With More Positive Affect? The Links Between Affects and Sports Club Membership Among French Adolescents.

Prior studies extensively examined the way sports club membership can lead to beneficial affective outcomes. Prior experiments also found that team sports, intensive sports, and sports that are frequently pursued can lead to even more affective benefits. However, no prior studies examined the differences between the affective benefits of specific sports.

Sport-Related Affective Benefits for Teenagers Are Getting Greater as They Approach Adulthood: A Large-Scale French Investigation.

The present investigation examined how sports club membership is related to adolescents' daily negative and positive affects as they age. Robust prior results demonstrated that sports club membership is positively related to positive affect and negatively related to negative affect. However, surprisingly, no prior studies examined whether these benefits are consistently present throughout the teenage years or there are certain critical periods when teenagers can affectively profit more from being members of a sports club.

Relationships between sports club participation and physical fitness and Body Mass Index in childhood.

Background: Physical fitness (PF) is a powerful determinant of health. The aim of this study was to examine the relationships between sports club (SC) participation and PF, and Body Mass Index (BMI) in children.

Methods: The population included 15,625 children (8029 boys and 7596 girls) 5 to 10 years old divided into three aged groups.

Rifampicin exposure reveals within-host Mycobacterium tuberculosis diversity in patients with delayed culture conversion.

Mycobacterium tuberculosis (Mtb) genetic micro-diversity in clinical isolates may underline mycobacterial adaptation to tuberculosis (TB) infection and provide insights to anti-TB treatment response and emergence of resistance. Herein we followed within-host evolution of Mtb clinical isolates in two cohorts of TB patients, either with delayed Mtb culture conversion (> 2 months), or with fast culture conversion (< 2 months). We captured the genetic diversity of Mtb isolates obtained in each patient, by focusing on minor variants detected as unfixed single nucleotide polymorphisms (SNPs).

Vaginal Tampon Colonization by Staphylococcus aureus in Healthy Women.

Tampons recovered from a cohort of 737 healthy women (median age, 32 years) were analyzed for the presence of A total of 198 tampons (27%) were colonized by , 28 (4%) by a strain producing toxic shock syndrome toxin 1 (TSST-1). was detected more frequently in tampons that did not require an applicator for their insertion (74/233 [32%] versus 90/381 [24%]; odds ratio [OR] = 1.51 [95% confidence interval, 1.

Effects of brief mindfulness instructions on reactions to body image stimuli among female smokers: an experimental study.

Introduction: Recent research has shown that body image stimuli increase negative affect and smoking urges among female smokers. Mindfulness (paying attention to present-moment experience with an attitude of nonjudgmental acceptance) may be a useful technique to minimize the influence of body dissatisfaction on negative affect, smoking urges, and smoking behavior.

Methods: This study investigated whether mindfulness influences how female college smokers respond to a body image challenge.