Publications by authors named "B.K. Chakrabarti"
Background: Sacubitril/valsartan, an angiotensin receptor-neprilysin inhibitor (ARNI), is an established treatment for heart failure (HF) with reduced left ventricular ejection fraction. It has not been rigorously compared with angiotensin-converting enzyme inhibitors in children. PANORAMA-HF (Prospective Trial to Assess the Angiotensin Receptor Blocker Neprilysin Inhibitor LCZ696 Versus Angiotensin-Converting Enzyme Inhibitor for the Medical Treatment of Pediatric HF) is a randomized, double-blind trial that evaluated the pharmacokinetics and pharmacodynamics (PK/PD), safety, and efficacy of sacubitril/valsartan versus enalapril in children 1 month to <18 years of age with HF attributable to systemic left ventricular systolic dysfunction (LVSD).
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- Altered myeloid inflammation and lymphopenia are key characteristics of severe infections, particularly in patients with acute lung injuries from SARS-CoV-2.
- The upregulated EN-RAGE gene program found in airway and blood myeloid cells is linked to increased clinical severity, predicting outcomes like mechanical ventilation and mortality.
- IL-6 was identified as a major factor driving myeloid dysfunction, and blocking its signaling with tocilizumab effectively normalized EN-RAGE gene expression and improved T cell function in clinical trials.
The feasibility and impact of implementing a computer-guided consultation to target health inequality in Asthma.
NPJ Prim Care Respir Med
February 2023
Greater Manchester has a greater prevalence and worse asthma outcomes than the national average. This study aims to evaluate a digital approach to primary care asthma management and in particular the initial impact of implementing Clinical Decision Support System software in the form of a computer-guided consultation (CGC) in the setting of primary care asthma reviews in deprived areas of Greater Manchester. The CGC (LungHealth Ltd) is an intelligent decision support system ensuring accurate guideline-based staging of asthma and assessment of asthma control with the software subsequently prompting guideline-standard management.
View Article and Find Full Text PDFLong non-coding RNAs (lncRNAs) are emerging as key regulators of endothelial cell function. Here, we investigated the role of a novel vascular endothelial-associated lncRNA (VEAL2) in regulating endothelial permeability. Precise editing of veal2 loci in zebrafish (veal2 ) induced cranial hemorrhage.
View Article and Find Full Text PDFWe report the direct observation of the excited L=1 state B_(s2)(*) in fully reconstructed decays to B+K-. The mass of the B_(s2)(*) meson is measured to be 5839.6+/-1.
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