Publications by authors named "B-E Gustafsson"
Article Synopsis
- * Out of 1116 trial participants, women showed lower rates of all-cause and cardiovascular mortality compared to men, yet ICDs did not significantly reduce mortality rates for either sex.
- * Both men and women had a reduced risk of sudden cardiovascular death with ICDs, but there was no overall survival advantage from ICD implantation in patients with nonischemic systolic heart failure.
Article Synopsis
- The DANISH study, which analyzed the effectiveness of implantable cardioverter defibrillators (ICDs) in patients with nonischemic systolic heart failure, found no overall survival advantage from ICDs over a median follow-up of 5.6 years, although younger patients (≤70 years) showed some reduction in all-cause mortality.
- The long-term follow-up extended the study duration to 9.5 years, involving 1,116 participants who were split between receiving an ICD or standard care.
- Results indicated that, while the ICD did not significantly lower overall mortality rates compared to control in the entire cohort, it did lead to a notable decrease in mortality among patients aged ≤70 years, whereas older patients
Background: Patients with nonischemic systolic heart failure (HF) have increased risk of sudden cardiac death (SCD) and death from progressive pump failure. Whether the risk of SCD changes over time is unknown. We seek here to investigate the relation between duration of HF, mode of death, and effect of implantable cardioverter-defibrillator implantation.
View Article and Find Full Text PDFBackground: The DANISH study (Danish Study to Assess the Efficacy of ICDs [Implantable Cardioverter Defibrillators] in Patients With Non-Ischemic Systolic Heart Failure on Mortality) did not demonstrate an overall effect on all-cause mortality with ICD implantation. However, the prespecified subgroup analysis suggested a possible age-dependent association between ICD implantation and mortality with survival benefit seen only in the youngest patients. The nature of this relationship between age and outcome of a primary prevention ICD in patients with nonischemic systolic heart failure warrants further investigation.
View Article and Find Full Text PDFCancers have dysfunctional redox regulation resulting in reactive oxygen species production, damaging both DNA and free dNTPs. The MTH1 protein sanitizes oxidized dNTP pools to prevent incorporation of damaged bases during DNA replication. Although MTH1 is non-essential in normal cells, we show that cancer cells require MTH1 activity to avoid incorporation of oxidized dNTPs, resulting in DNA damage and cell death.
View Article and Find Full Text PDF