Publications by authors named "B van der Hoven"
Background & Aims: The use of indirect calorimetry to determine energy requirements is highly recommended in critically ill patients. To facilitate this a new and easy to use calorimeter (Q-NRG+, Cosmed) was developed. The primary aim of our study was to describe the usefulness of this calorimeter and, secondarily, to investigate the agreement between measured and predicted energy needs in a large cohort of critically ill adult patients.
View Article and Find Full Text PDFBackground: Most critically ill patients with COVID-19 experience malnutrition and weight loss associated with negative clinical outcomes. Our primary aim was to assess body composition during acute and late phase of illness in these patients in relation to clinical outcome and secondary to tailored nutrition support.
Methods: This prospective cohort study included adult critically ill patients with COVID-19.
Article Synopsis
- The study investigated the relationship between nutritional intake and gastrointestinal (GI) symptoms in critically ill COVID-19 patients during their first 14 days in the ICU.
- Results showed that while most patients received enteral nutrition, the achievement of energy and protein goals improved over time, despite the presence of GI symptoms.
- Moderate GI symptoms decreased, and although fluctuations in GI dysfunction and high gastric residual volumes occurred, no patients experienced severe GI failure (grade IV).
Article Synopsis
- Recent research found loss-of-function variants in a small number of males that may increase susceptibility to severe COVID-19, focusing on young men aged 18-50 without major health issues.
- In a study of 14 patients, two had missense variants linked to severe COVID-19, with both variants being novel and potentially harmful.
- The findings highlight the importance of genetic screening for these variants in young men with severe COVID-19, as it could guide treatment and help identify at-risk family members for early intervention.
Purpose: Influenza-associated pulmonary aspergillosis (IAPA) is a frequent complication in critically ill influenza patients, associated with significant mortality. We investigated whether antifungal prophylaxis reduces the incidence of IAPA.
Methods: We compared 7 days of intravenous posaconazole (POS) prophylaxis with no prophylaxis (standard-of-care only, SOC) in a randomised, open-label, proof-of-concept trial in patients admitted to an intensive care unit (ICU) with respiratory failure due to influenza (ClinicalTrials.