Publications by authors named "B van Rietbergen"
Purpose: Accurate measurements of trabecular bone microarchitecture are required for a proper assessment of bone fragility. Photon-counting detector CT (PCD-CT) has different technical properties than conventional CT, resulting in higher resolution and thereby potentially enabling in-vivo measurement of trabecular microarchitecture. The purpose of this study was to quantify trabecular bone microarchitectural parameters with PCD-CT at varying radiation doses and compare this to µCT as gold standard.
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- - X-linked Hypophosphatemia (XLH) is a common inherited rickets condition, but its effects on bone structure and properties are not well understood; this study analyzed bone characteristics in adults with XLH compared to healthy controls.
- - Findings showed that patients had higher areal bone mineral density (aBMD) and trabecular bone scores at the lumbar spine, but lower volumetric BMD and trabecular measures at the distal radius, indicating mixed bone quality.
- - Over time, a follow-up revealed declines in total and cortical volumetric BMD at the tibia, suggesting that while XLH patients have some higher densities initially, microarchitectural issues worsen with age.
Article Synopsis
- * Sarcopenia (muscle loss) and osteoporosis (bone loss) are closely linked, with each condition serving as a predictor for the other, indicating the need for integrated research approaches.
- * A recent workshop emphasized the importance of muscle characterization in musculoskeletal studies, advocating for more recognition and research on muscle phenotyping in both human and animal models like zebrafish and mice.
Objective: Osteoarthritis (OA) is characterized by articular cartilage erosion, pathological subchondral bone changes, and signs of synovial inflammation and pain. We previously identified p[63-82], a bone morphogenetic protein 7 (BMP7)-derived bioactive peptide that attenuates structural cartilage degeneration in the rat medial meniscal tear-model for posttraumatic OA. This study aimed to evaluate the cartilage erosion-attenuating activity of p[63-82] in a different preclinical model for OA (anterior cruciate ligament transection-partial medial meniscectomy [anterior cruciate ligament transection (ACLT)-pMMx]).
View Article and Find Full Text PDFData on bone microarchitecture in osteogenesis imperfecta (OI) are scarce. The aim of this cross-sectional study was to assess bone microarchitecture and strength in a large cohort of adults with OI using high-resolution peripheral quantitative computed tomography (HR-pQCT) and to evaluate challenges of using HR-pQCT in this cohort. Second-generation HR-pQCT scans were obtained at the distal radius and tibia in 118 men and women with Sillence OI type I, III, or IV using an extremity-length-dependent scan protocol.
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