Publications by authors named "B van Dalen"
Article Synopsis
- The study investigates the link between left atrial (LA) cardiomyopathy and premature atrial contractions (PACs) in individuals with severe obesity, aiming to improve understanding of atrial fibrillation (AF) risk.
- The research involved 192 obese subjects and 50 non-obese controls, using methods like Holter monitoring and echocardiography to analyze heart health.
- Results showed that larger LA size correlated with more PACs in the obese group, but no AF was detected, suggesting a need for better screening methods incorporating LA health in this population.
Circulating proteins may provide insights into the varying biological mechanisms involved in heart failure (HF) with preserved ejection fraction (HFpEF) and reduced ejection fraction (HFrEF). We aimed to identify specific proteomic patterns for HF, by comparing proteomic profiles across the ejection fraction spectrum. We investigated 4210 circulating proteins in 739 patients with normal (Stage A/Healthy) or elevated (Stage B) filling pressures, HFpEF, or ischemic HFrEF (iHFrEF).
View Article and Find Full Text PDFBackground: Although anxiety and depression have been associated with adverse outcomes in chronic heart failure (HF), data on temporal evolution of these symptoms are scarce. We aimed to investigate the association between repeatedly measured depression and anxiety symptoms and clinical outcome in chronic HF patients.
Methods: In this prospective observational study, outpatients with chronic HF were included and followed-up for a maximum of 2.
Article Synopsis
- The TITRATE-HF study investigates the real-world application and barriers to guideline-directed medical therapy (GDMT) for heart failure patients, aligning with the 2021 ESC HF guidelines and 2023 updates.
- Conducted in the Netherlands, the study involved 4,288 patients, highlighting that while 44% of chronic and worsening heart failure patients received quadruple therapy, only 1% achieved target doses for all drug classes.
- The findings indicate that there is significant room for improvement in GDMT usage and dosing, emphasizing the need for enhanced strategies in heart failure management.
The plasma proteome is linked with left ventricular and left atrial function parameters in patients with chronic heart failure.
Eur Heart J Cardiovasc Imaging
August 2024
Aims: Examining the systemic biological processes in the heterogeneous syndrome of heart failure with reduced ejection fraction (HFrEF), as reflected by circulating proteins, in relation to echocardiographic characteristics, may provide insights into heart failure pathophysiology. We investigated the link of 4210 repeatedly measured circulating proteins with repeatedly measured echocardiographic parameters as well as with elevated left atrial pressure (LAP), in patients with HFrEF, to provide insights into underlying mechanisms.
Methods And Results: In 173 patients with HFrEF, we performed 6-monthly echocardiography and trimonthly blood sampling during a median follow-up of 2.