Publications by authors named "B de Laval"
Hematopoietic stem cells (HSCs) are a rare, long-lived and multipotent population that give rise to majority of blood cells and some tissue-resident immune cells. There is growing evidence that inflammatory stimuli can trigger persistent reprogramming in HSCs that enhances or inhibits the cellular functions of these HSCs and their progeny in response to subsequent infections. This newly discovered property makes HSCs a reservoir for innate immune memory.
View Article and Find Full Text PDFTherapies reconstituting autologous antiviral immunocompetence may represent an important prophylaxis and treatment for immunosuppressed individuals. Following hematopoietic cell transplantation (HCT), patients are susceptible to Herpesviridae including cytomegalovirus (CMV). We show in a murine model of HCT that macrophage colony-stimulating factor (M-CSF) promoted rapid antiviral activity and protection from viremia caused by murine CMV.
View Article and Find Full Text PDFArticle Synopsis
- Hematopoietic stem cells (HSC) are primarily known for maturing into immune cells that respond to infections, but recent findings indicate they can also directly detect cytokines during infections and maintain memory of them.
- HSC's direct sensing of danger signals leads to early myeloid commitment, enhancing the production of myeloid cells that are crucial for a robust immune response.
- The study reveals that HSC can recognize the pathogenic bacteria B. abortus in the bone marrow through the interaction of the CD150 protein with a bacterial protein (Omp25), marking the first time this direct pathogen recognition by HSC has been observed.