The impact of preoperative maintaining antithrombotic therapy in patients undergoing non-coronary endovascular interventions.

Background: Antithrombotic medications, including antiplatelet and anticoagulant therapies, are widely used to prevent thromboembolic events in patients with cardiovascular diseases. It is common for patients on antithrombotic medications to undergo endovascular interventions though potential complications remain unclear. This study investigated the impact of continuing antithrombotic medications before endovascular interventions on perioperative clinical outcomes, particularly intraoperative blood transfusion.

Screening necroptosis genes influencing osteoarthritis development based on machine learning.

Machine learning can be applied to identify key genes associated with osteoarthritis (OA). This study aimed to explore the differential expression of necroptosis-related genes (NRGs) during the progression of OA, identify key gene modules strongly linked to the onset of OA, and assess the role of CASP1 and its correlation with immune cell infiltration in OA. Gene expression profile data were obtained for OA and normal tissues: GSE55235 (10 OA and 10 normal synovial tissues) and GSE46750 (12 OA and 12 normal synovial tissues).

Long-term weight change and transition of metabolic health status in middle life and the risk of atrial fibrillation.

Background: The association of long-term weight change with atrial fibrillation (AF) risk remains controversial and evidence for the effect of metabolic health transition on AF is limited.

Objective: To evaluate the effects of body mass index (BMI) change and transition in BMI-metabolic health status on AF.

Methods: We conducted a prospective cohort study within UK Biobank.

Naturally inspired chimeric quinolone derivatives to reverse bacterial drug resistance.

Antimicrobial resistance poses an urgent threat to global health, underscoring the critical need for new antibacterial drugs. Ciprofloxacin, a third-generation quinolone antibiotic, is used to treat different types of bacterial infections; however, it often results in the rapid emergence of resistance in clinical settings. Inspired by low susceptibility to antimicrobial resistance of natural antimicrobial peptides, we herein propose a host defense peptide-mimicking strategy for designing chimeric quinolone derivatives which may reduce the likelihood of antibacterial resistance.

Research trends of neoadjuvant therapy in lung cancer: a bibliometric analysis.

Background: Lung cancer is the most prevalent malignancy worldwide. Only a fraction of early-stage patients undergo radical surgery; however, many still experience recurrence and metastasis within 5 years postoperatively (approximately 30-75%). Neoadjuvant therapy has revolutionized the treatment approach for lung cancer, with a growing number of clinical trials investigating this modality.